Abstract：
:Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific technologies and in our knowledge of how protective immune responses are induced enable us to rationally design novel and safer vaccination strategies. Such advances have accelerated the development of inactivated whole-organism- and subunit-based vaccines. In this review, we discuss ideal attributes and criteria that need to be considered for the development of vaccines and some existing vaccine platforms. We focus on inactivated vaccines against influenza virus and ways by which vaccine efficacy can be improved with the use of adjuvants and Toll-like receptor-2 signaling.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Chua BY,Sekiya T,Jackson DCdoi
10.1089/vim.2017.0146subject
Has Abstractpub_date
2018-03-01 00:00:00pages
150-158issue
2eissn
0882-8245issn
1557-8976journal_volume
31pub_type
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