Abstract:
:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homogenates and diminished immunohistochemical detection of VSV antigens in tissue sections; 4) earlier and increased CNS expression of types 1, 2, and 3 nitric oxide synthase (NOS) and both major histocompatibility complex (MHC) class I and class II antigens; 5) earlier and increased blood and CNS levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). These results suggest that IL-12 enhances recovery from VSV infection of the CNS.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Komatsu T,Barna M,Reiss CSdoi
10.1089/vim.1997.10.35subject
Has Abstractpub_date
1997-01-01 00:00:00pages
35-47issue
1eissn
0882-8245issn
1557-8976journal_volume
10pub_type
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