Abstract：
:Cervical intraepithelial neoplasias (CINs) are a major public health issue. The prevalence of CINs is higher in women with the human immunodeficiency virus (HIV). The objective of this study was to determine whether there are differences in the immune responses in the cervical stroma of HIV-infected and -uninfected women with CIN. The responses were assessed according to the immunohistochemical expression of cytokines interleukin (IL)-4, IL-12, interferon gamma (IFN-γ), and tumor growth factor beta (TGF-β). In addition, we determined whether there were differences in the local immune responses between patients with CIN1 and CIN 2/3. A cross-sectional study was performed using material collected by cervical conization in HIV-infected and -uninfected women with CIN. The conization was performed using loop electrical excision procedure (LEEP) from January 1999 to May 2004. The evaluation of cytokines in the cervical stroma was based on immunohistochemistry. No differences were found between the two groups of women regarding HIV status. However, the associations between IL-12 expression and CIN 2/3 (p=0.016) in HIV-infected women and between IL-4 expression and CIN 1 (p=0.0456) in HIV-infected women were significant when the interaction between HIV infection and lesion grade was assessed. Additionally, a significant association between TGF-β expression and CIN 2/3 in both groups was observed regardless of HIV infection (p=0.000). An interaction between HIV infection and CIN grade was detected because IL-12 and IL-4 expression increased in the presence of HIV infection. Regarding the CIN grade, there was a high prevalence of TGF-β in CIN 2/3 lesions, which reflected the predominance of an immunoregulatory environment.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Guimarães MV,Michelin MA,Lucena AA,Lodi CT,Lima MI,Murta EF,Melo VHdoi
10.1089/vim.2014.0032subject
Has Abstractpub_date
2014-09-01 00:00:00pages
350-5issue
7eissn
0882-8245issn
1557-8976journal_volume
27pub_type
杂志文章相关文献
VIRAL IMMUNOLOGY文献大全abstract：:We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1997.10.197
更新日期：1997-01-01 00:00:00
abstract：:Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy and scrapie in sheep and goats. Transmissible spongiform encephalopathies are thought by some to result from changes in the conformation of a membrane glyco...
journal_title：Viral immunology
pub_type： 杂志文章,评审
doi：10.1089/vim.2004.17.334
更新日期：2004-01-01 00:00:00
abstract：:Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in ...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2014.0095
更新日期：2015-04-01 00:00:00
abstract：:Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...
journal_title：Viral immunology
pub_type： 杂志文章,评审
doi：10.1089/vim.2017.0146
更新日期：2018-03-01 00:00:00
abstract：:Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1995.8.165
更新日期：1995-01-01 00:00:00
abstract：:Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/08828240050144680
更新日期：2000-01-01 00:00:00
abstract：:Bacterial flagellin is a potent adjuvant that enhances adaptive immune responses to a variety of protein antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore we evaluated the humoral res...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2009.0107
更新日期：2010-04-01 00:00:00
abstract：:Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1996.9.51
更新日期：1996-01-01 00:00:00
abstract：:Reovirus has previously been classified into three serotypes based on hemagglutination inhibition assays. In the present study, the specificity of cytotoxic T lymphocytes (CTL) generated in reovirus type 3-infected C3H/HeN mice was investigated at the population and clonal levels. Short-term CTL lines generated in res...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1991.4.167
更新日期：1991-10-01 00:00:00
abstract：:Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the ...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2012.0001
更新日期：2012-06-01 00:00:00
abstract：:Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in immunocompromised hosts, many of whom undergo significant periods of lymphopenia. However, the impact of lymphopenia and subsequent immune reconstitution on T cell responses and pulmonary pathology are poorly understood. Using a model of primar...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2015.0005
更新日期：2015-06-01 00:00:00
abstract：:Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1991.4.83
更新日期：1991-07-01 00:00:00
abstract：:To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR),...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2016.0135
更新日期：2017-09-01 00:00:00
abstract：:The present study describes an approach to the development and use of anti-idiotypic antibodies as a possible immunization strategy to prevent retroviral infection. The rationale for using anti-idiotypes (anti-Ids) to try to elicit an antigenic-specific immune response is examined, and the production and characterizat...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1991.4.5
更新日期：1991-04-01 00:00:00
abstract：:BALB/c mice, preimmunized with a protective dose of native herpes simplex virus type 1 glycoprotein D (ngD1) vaccine, were depleted of selected immunocyte populations in vivo using monoclonal antibodies directed at Thy1+, L3T4+, or Lyt2+ cells. Following immunization and depletion, animals were inoculated with varied ...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1992.5.151
更新日期：1992-07-01 00:00:00
abstract：:Today, hepatitis C virus (HCV) infection is considered as one of the most significant international health concerns. Although novel therapeutic regimens against the infection have shown satisfactory results, no approved vaccine exists yet. This study aimed to evaluate the immunogenicity of a DNA vaccine candidate for ...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2015.0085
更新日期：2016-04-01 00:00:00
abstract：:The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/088282401750234529
更新日期：2001-01-01 00:00:00
abstract：:Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2005.18.381
更新日期：2005-01-01 00:00:00
abstract：:In this study we investigated the efficacy of a multigenic DNA prime/modified vaccinia Ankara (MVA)boost vaccine approach, followed by mucosal challenge with highly pathogenic simian-human immunodeficiency virus (SHIV) 89.6P, using different routes for vaccine delivery. After three times of DNA priming (SIVmac239, Gag...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2007.0103
更新日期：2008-06-01 00:00:00
abstract：:The human papillomavirus (HPV) is an important causal agent of premalignant cervical epithelial changes and cervical cancers. These cancers account for ∼5% of all cancers globally and kill more than a quarter million women annually. HPV infections also associate with certain anogenital and oropharyngeal cancers. Event...
journal_title：Viral immunology
pub_type： 杂志文章,评审
doi：10.1089/vim.2017.0119
更新日期：2018-03-01 00:00:00
abstract：:In the developing countries, Hepatitis E virus (HEV) is a predominant cause of sporadic acute hepatitis in adults and waterborne epidemics leading to high mortality in pregnant women. Vaccine development mainly focuses on the structural capsid protein open-reading-frame-2 (ORF-2) of the virus. We successfully evaluate...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2016.0024
更新日期：2016-07-01 00:00:00
abstract：:Highly pathogenic avian influenza (HPAI) H5N1 virus emerged in 1997 as a zoonotic disease in Hong Kong. It has since spread to Asia and Europe and is a serious threat to both the poultry industry and human health. For effective surveillance and possible prevention/control of HPAI H5N1 viruses, it is necessary to under...
journal_title：Viral immunology
pub_type： 杂志文章,评审
doi：10.1089/vim.2017.0020
更新日期：2017-07-01 00:00:00
abstract：:We have previously demonstrated the formation and release of influenza virus-like particles (VLPs) from the surface of Sf9 cells infected with either a quadruple baculovirus recombinant that simultaneously expresses the influenza structural proteins hemagglutinin (HA), neuraminidase (NA), matrix 1 (M1) and M2, or a co...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2005.18.244
更新日期：2005-01-01 00:00:00
abstract：:As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...
journal_title：Viral immunology
pub_type： 杂志文章,评审
doi：10.1089/088282402317340260
更新日期：2002-01-01 00:00:00
abstract：:We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2020.0064
更新日期：2020-11-01 00:00:00
abstract：:Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2006.19.409
更新日期：2006-07-01 00:00:00
abstract：:A molecular form of soluble suppressor factor was identified in serum-free supernatant fluid of cultured peripheral blood mononuclear cells (PBMC) from patients with severe forms of papillomavirus infections (epidermodysplasia verruciformis and large treatment-resistant condyloma acuminatum). The papillomavirus-induce...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1991.4.249
更新日期：1991-01-01 00:00:00
abstract：:Herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, early rapid and reliable diagnosis has become important. The objective of the present study was to develop a sensitive enzyme-linked immunosorbent assay (EL...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2010.0129
更新日期：2011-08-01 00:00:00
abstract：:Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 c...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.2014.0017
更新日期：2014-11-01 00:00:00
abstract：:Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...
journal_title：Viral immunology
pub_type： 杂志文章
doi：10.1089/vim.1993.6.75
更新日期：1993-04-01 00:00:00
