Abstract:
:Cholangiocarcinoma is a malignancy of the biliary duct system. Presently, these malignant biliary tract diseases are common among the people in Southeast Asia, with the world's highest prevalence in northeastern Thailand and Laos. This carcinoma tends to grow slowly and to infiltrate the walls of the ducts, dissecting along tissue planes and leading to biliary tract obstruction. Recently, hepatitis virus-associated chronic hepatitis or cirrhosis has been suggested to be involved in the pathogenesis of cholangiocarcinoma. Here, we report the prevalence of hepatitis B seropositivity among Thai patients with cholangiocarcinoma. A total of 55 patients with cholangiocarcinoma, who were admitted to King Chulalongkorn Memorial Hospital, Thailand, during 1992-2001, with known hepatitis B serology was selected for further prevalence study. Of the 55 cases (32 males and 22 females), hepatitis B seropositivity was found in five cases (three males and two females), giving a total prevalence rate equal to 9.1% (9.4% for male and 9.2% for females). Since hepatitis B infection is believed to be a risk factor in the development of cholangiocarcinoma, and both cholangiocarcinoma and hepatitis B infection are common in Thailand, screening and vaccination for hepatitis B may be a useful strategy to decrease the high rate of cholangiocarcinoma in Thailand. Further long-term study to study the relation of hepatitis B infection and cholangiocarcinoma is recommended.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Pinyosophon A,Wiwanitkit Vdoi
10.1089/088282402320914593subject
Has Abstractpub_date
2002-01-01 00:00:00pages
655-7issue
4eissn
0882-8245issn
1557-8976journal_volume
15pub_type
杂志文章相关文献
VIRAL IMMUNOLOGY文献大全abstract::A 90-amino acid peptide from the simian rotavirus SA-11 nonstructural protein, NSP4 was linked to the N-terminus of the Ricinus communis A-B toxin B subunit protein (RTB) and synthesized in Escherichia coli. Recombinant RTB and the NSP4(90)::RTB fusion protein bound artificial receptor glycoprotein asialofetuin in an ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.54
更新日期:2006-04-01 00:00:00
abstract::Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0088
更新日期:2011-04-01 00:00:00
abstract::Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in immunocompromised hosts, many of whom undergo significant periods of lymphopenia. However, the impact of lymphopenia and subsequent immune reconstitution on T cell responses and pulmonary pathology are poorly understood. Using a model of primar...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2015.0005
更新日期:2015-06-01 00:00:00
abstract::Toll-like receptor (TLR)3 signaling pathway is known to induce type 1 interferons (IFNs) and proinflammatory mediators leading to antiviral response against many viral infections. Double-stranded ribonucleic acid (dsRNA) has been shown to act as a ligand for TLR3 and, as such, has been a focus as a potential antiviral...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0142
更新日期:2018-07-01 00:00:00
abstract::Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0029
更新日期:2014-11-01 00:00:00
abstract::Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0117
更新日期:2011-06-01 00:00:00
abstract::Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1993.6.75
更新日期:1993-04-01 00:00:00
abstract::Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2016.0062
更新日期:2016-12-01 00:00:00
abstract::Bacterial flagellin is a potent adjuvant that enhances adaptive immune responses to a variety of protein antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore we evaluated the humoral res...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0107
更新日期:2010-04-01 00:00:00
abstract::Reovirus has previously been classified into three serotypes based on hemagglutination inhibition assays. In the present study, the specificity of cytotoxic T lymphocytes (CTL) generated in reovirus type 3-infected C3H/HeN mice was investigated at the population and clonal levels. Short-term CTL lines generated in res...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1991.4.167
更新日期:1991-10-01 00:00:00
abstract::Mannan-binding lectin (MBL) is a collectin that mediates activation of the complement system and is of importance for host defenses. In humans low concentrations of MBL in serum have been associated with susceptibility to several viral diseases. To understand the function of MBL in relation to infectious viral disease...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0036
更新日期:2007-12-01 00:00:00
abstract::Acute hepatitis C virus (HCV) infection is usually asymptomatic, therefore, early diagnosis is rare. It may remain undiagnosed in individuals who progress to chronic infection, often until serious liver damage has developed. To incorporate the diagnosis of this viral disease in a multiple-diagnostic assay, we first an...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2018.0023
更新日期:2018-10-01 00:00:00
abstract::Essen regimen, the Thai Red Cross two-site ID regimen, Zagreb schedule, and the eight-site ID regimen are the standard rabies vaccines recommended by the World Health Organization (WHO). In this study, a liposomal rabies vaccine (LipoRV) was developed, which was found to facilitate the production of rabies virus neutr...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0093
更新日期:2017-12-01 00:00:00
abstract::Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0134
更新日期:2018-05-01 00:00:00
abstract::Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0102
更新日期:2020-10-05 00:00:00
abstract::Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0098
更新日期:2018-05-01 00:00:00
abstract::The VP1 represents the major capsid protein of the hamster polyomavirus (HaPV). Here we describe the mapping of epitopes along the VP1 using Escherichia coli-expressed VP1-dihydrofolate reductase (DHFR) fusion proteins and PepScan analysis. By use of DHFR fusion proteins an immunodominant region was localized in the C...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2000.13.533
更新日期:2000-01-01 00:00:00
abstract::Hepatitis C virus (HCV) signifies an important health issue as it is a globally prevalent pathogen and poses a great threat to human health. Direct antiviral therapy became a landmark in treatment against chronic HCV infection as they have proven to increase sustained virological response (SVR) rate, provide shortened...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0124
更新日期:2018-04-01 00:00:00
abstract::Infection with helper-free, defective MAIDS murine leukemia virus (MuLV) caused a rapid polyclonal activation of B cells in 0.75-, 2-, and 6-month-old C57L/J mice (H-2b, Fv-1n/n), similar to that in C57BL/6 mice (H-2b, Fv-1b/b), which was recognized by elevated plasma immunoglobulin concentrations. However, changes in...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1992.5.39
更新日期:1992-04-01 00:00:00
abstract::Findings coming from autopsies and serum of SARS patients suggest an important immune-inflammatory implication in the evolution to respiratory distress. Conditions such as HIV infection or treatment with immunosuppressors (in cancer or autoimmune diseases) are not among the bad prognosis factors for development of dis...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2004.17.535
更新日期:2004-01-01 00:00:00
abstract::Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0127
更新日期:2014-08-01 00:00:00
abstract::The human papillomavirus (HPV) is an important causal agent of premalignant cervical epithelial changes and cervical cancers. These cancers account for ∼5% of all cancers globally and kill more than a quarter million women annually. HPV infections also associate with certain anogenital and oropharyngeal cancers. Event...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0119
更新日期:2018-03-01 00:00:00
abstract::A paresis isolate of equid herpesvirus 1 (EHV1, Ab4/8) and a plaque-purified virus derived from it (EHV1, Ab4/13), induced long-term suppression of both mitogenic and antigen-specific lymphocyte proliferations in adult outbred ponies. Peripheral blood mononuclear cells (PBMC) taken from a pony after EHV1 infection sup...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1999.12.313
更新日期:1999-01-01 00:00:00
abstract::We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0064
更新日期:2020-11-01 00:00:00
abstract::Expression of the high-affinity interleukin 2 receptor alpha chain (CD25) was used to monitor antigen-specific activation of T lymphocyte subsets (CD4+, CD8+, and gammadelta T cells) from cattle immunized with modified live bovine herpesvirus-1 (BHV-1). Calves seronegative for BHV-1 were either vaccinated with one dos...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240260066305
更新日期:2002-01-01 00:00:00
abstract::The ability of a highly divergent antigenic site of foot-and-mouth disease virus (FMDV) of serotype C to elicit neutralizing antibodies has been evaluated in mice and rabbits. The viruses compared, FMDV C-S8c1 and HR, differ in a single amino acid replacement in their capsid proteins, but represent two extreme antigen...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1995.8.11
更新日期:1995-01-01 00:00:00
abstract::The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...
journal_title:Viral immunology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1089/vim.2014.0094
更新日期:2015-04-01 00:00:00
abstract::Naïve CD8(+) T cells differentiate into effectors secreting various cytokines that modulate immune functions. A striking finding for most HIV-1-infected patients is that they accumulate CD8(+) T cells belonging to early and intermediate differentiated elements. Structural HIV-1 proteins, and among these the matrix pro...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0095
更新日期:2008-06-01 00:00:00
abstract::Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0041
更新日期:2007-09-01 00:00:00
abstract::There is limited information on the direct role of the neutralizing antibody responses against hepatitis C virus (HCV) infection or methodologies to study them. Previously we have demonstrated that interleukin-10 (IL-10) administered to chronic hepatitis patients led to a decrease in disease activity, but an increase ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0095
更新日期:2010-08-01 00:00:00