Abstract:
:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may support CD8(+) T cells through secretion of interleukin-2 (IL-2). To determine the in vivo role of IL-2 during CNS infection, IL-2 signaling was inhibited via administration of a neutralizing IL-2-specific monoclonal antibody (mAb). In contrast to depletion of CD4(+) T cells, inhibition of IL-2 signaling did not influence CD8(+) T cell infiltration, effector cell function or survival within the CNS. These data suggest that the cellular immune response to acute neurotropic JHMV infection requires a distinct CD4(+) T cell component, but is independent of a requirement for IL-2 for induction, activation, recruitment, and/or maintenance of CD8(+) T cells within the CNS during acute infection.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NWdoi
10.1089/vim.2005.18.162subject
Has Abstractpub_date
2005-01-01 00:00:00pages
162-9issue
1eissn
0882-8245issn
1557-8976journal_volume
18pub_type
杂志文章相关文献
VIRAL IMMUNOLOGY文献大全abstract::Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240050144680
更新日期:2000-01-01 00:00:00
abstract::Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1993.6.75
更新日期:1993-04-01 00:00:00
abstract::During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.1989.2.263
更新日期:1989-01-01 00:00:00
abstract::Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC fu...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2011.0025
更新日期:2011-10-01 00:00:00
abstract::Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0041
更新日期:2007-09-01 00:00:00
abstract::Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402317340323
更新日期:2002-01-01 00:00:00
abstract::Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.283
更新日期:2005-01-01 00:00:00
abstract::CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0076
更新日期:2010-12-01 00:00:00
abstract::Today, hepatitis C virus (HCV) infection is considered as one of the most significant international health concerns. Although novel therapeutic regimens against the infection have shown satisfactory results, no approved vaccine exists yet. This study aimed to evaluate the immunogenicity of a DNA vaccine candidate for ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2015.0085
更新日期:2016-04-01 00:00:00
abstract::Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1997.10.35
更新日期:1997-01-01 00:00:00
abstract::To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1998.11.79
更新日期:1998-01-01 00:00:00
abstract::In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centril...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0041
更新日期:2017-05-01 00:00:00
abstract::Baculovirus is an efficient system for the gene expression that can be used for gene transfer to both insect and different vertebrate hosts. The nucleocapsid gene (N) of the infectious bronchitis virus was cloned in a baculovirus expression system for insect cell expression. Dual expression vectors containing IBV N an...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0114
更新日期:2014-03-01 00:00:00
abstract::We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2011.0091
更新日期:2012-06-01 00:00:00
abstract::Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0138
更新日期:2018-03-01 00:00:00
abstract::BALB/c mice, preimmunized with a protective dose of native herpes simplex virus type 1 glycoprotein D (ngD1) vaccine, were depleted of selected immunocyte populations in vivo using monoclonal antibodies directed at Thy1+, L3T4+, or Lyt2+ cells. Following immunization and depletion, animals were inoculated with varied ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1992.5.151
更新日期:1992-07-01 00:00:00
abstract::Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1995.8.165
更新日期:1995-01-01 00:00:00
abstract::Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0146
更新日期:2018-03-01 00:00:00
abstract::We performed a comprehensive analysis of innate and adaptive immune responses in dual-virus infected pigs to understand whether a pre-existing immunomodulatory respiratory viral infection affects the overall immunity to a subsequent porcine respiratory coronavirus (PRCV) infection in pigs. Pigs were either mock-infect...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0051
更新日期:2010-10-01 00:00:00
abstract::Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1995.8.53
更新日期:1995-01-01 00:00:00
abstract::C57BL/6 mice can generate a type-specific and class IH-2Kb-restricted CTL response against histocompatible AKR/Gross murine leukemia virus (MuLV) cell surface antigen positive (GCSA+) tumor cells. These anti-AKR/Gross MuLV CTL are also known to lyse SC.Kb/623 target cells expressing the molecular MuLV clone AKR623 (de...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1994.7.51
更新日期:1994-01-01 00:00:00
abstract::Monoclonal antibodies were used to characterize neutralizing epitopes on VP2 of bluetongue virus serotype 10 (BTV-10). Six neutralizing monoclonal antibodies that immune precipitated VP2 demonstrated two distinct patterns of reactivity in the competitive enzyme-linked immune absorbent assay (ELISA). These results sugg...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1990.3.161
更新日期:1990-07-01 00:00:00
abstract::Antigen-primed cytotoxic T lymphocytes (CTL) may express leukocyte immunoglobulin-like receptors (LILRs) and natural killer receptors (NKRs). Published work suggests that expression of some of these receptors confers survival advantage, leading to the idea that cells expressing such receptors may accumulate as an anti...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.513
更新日期:2005-01-01 00:00:00
abstract::Naïve CD8(+) T cells differentiate into effectors secreting various cytokines that modulate immune functions. A striking finding for most HIV-1-infected patients is that they accumulate CD8(+) T cells belonging to early and intermediate differentiated elements. Structural HIV-1 proteins, and among these the matrix pro...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0095
更新日期:2008-06-01 00:00:00
abstract::Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0095
更新日期:2015-04-01 00:00:00
abstract::Synthetic oligodeoxynucleotides (ODNs) such as CpG can stimulate B and plasmacytoid dendritic cells in vertebrate immune systems. Several studies showed that non-CpG ODNs could also induce strong stimulation of B and T cells. PyNTTTTGT ODNs, non-CpG ODNs, can activate and cause immunoglobulin secretion by B cells and ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0073
更新日期:2009-04-01 00:00:00
abstract::Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.381
更新日期:2005-01-01 00:00:00
abstract::Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402320914539
更新日期:2002-01-01 00:00:00
abstract::Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2012.0001
更新日期:2012-06-01 00:00:00
abstract::Hepatitis E virus (HEV) is one of the primary causative agents of acute hepatitis. It is noteworthy that HEV can develop chronic infection and even lead to liver cirrhosis; however, the mechanism has not been revealed. In this study, the ELISA assay was used to detect protein levels, and we found that HEV open reading...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2015.0107
更新日期:2016-03-01 00:00:00