Abstract:
:Monoclonal antibodies were used to characterize neutralizing epitopes on VP2 of bluetongue virus serotype 10 (BTV-10). Six neutralizing monoclonal antibodies that immune precipitated VP2 demonstrated two distinct patterns of reactivity in the competitive enzyme-linked immune absorbent assay (ELISA). These results suggest that there are at least two distinct domains of neutralization on VP2 of BTV. Monoclonal antibodies defining the two domains were serotype-restricted in plaque neutralization, immune precipitation or ELISA. One of the two neutralizing domains also demonstrated significant hemagglutinating activity. Both cattle and sheep infected with BTV-10 produce antibodies to the two neutralizing epitopes.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Mecham JO,Jochim MMdoi
10.1089/vim.1990.3.161subject
Has Abstractpub_date
1990-07-01 00:00:00pages
161-70issue
2eissn
0882-8245issn
1557-8976journal_volume
3pub_type
杂志文章相关文献
VIRAL IMMUNOLOGY文献大全abstract::Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1996.9.51
更新日期:1996-01-01 00:00:00
abstract::Studies of immune function in human immunodeficiency virus (HIV)-infected children are important, because functional abnormalities can precede CD4+ T-cell loss and are associated with the development of opportunistic and bacterial infections. We sought to correlate clinical parameters and immunological function with H...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1999.12.139
更新日期:1999-01-01 00:00:00
abstract::California (CAL) serogroup Bunyaviruses are significant agents of arboviral encephalitis in humans. They are maintained and transmitted in nature by mosquitoes to preferred vertebrate amplifying hosts. The G2 envelope glycoprotein of La Crosse virus (LAC) was proposed by Ludwig et al. to be a determinant for virus att...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2000.13.201
更新日期:2000-01-01 00:00:00
abstract::Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1991.4.83
更新日期:1991-07-01 00:00:00
abstract::Dengue virus (DENV) is an arthropod-borne virus, which belongs to the Flaviviridae family, and completes its life cycle in two hosts: humans and mosquitoes. For DENV maturation, the surface pre-membrane (prM) protein is cleaved to form a mature membrane protein (M) by furin, which is a cellular enzyme subsequently rel...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2015.0034
更新日期:2015-09-01 00:00:00
abstract::Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0134
更新日期:2018-05-01 00:00:00
abstract::Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1995.8.165
更新日期:1995-01-01 00:00:00
abstract::We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1997.10.197
更新日期:1997-01-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be an economically important infectious disease of swine. Mechanisms governing activation of the innate immune response to PRRSV remain to be elucidated. Virulence differences observed between PRRSV isolates have been attributed to replication ab...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0038
更新日期:2008-09-01 00:00:00
abstract::Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0117
更新日期:2011-06-01 00:00:00
abstract::Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC fu...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2011.0025
更新日期:2011-10-01 00:00:00
abstract::TransFix(TM) and Cyto-Chex((R)) BCT (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. We evaluated the ability of these blood-stabilizing reagents to preserve HIV-seropositive blood for delayed CD4(+) T-cell quantification utilizing the ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0027
更新日期:2009-10-01 00:00:00
abstract::In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centril...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0041
更新日期:2017-05-01 00:00:00
abstract::Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2016.0062
更新日期:2016-12-01 00:00:00
abstract::Genetic polymorphism of IFNAR-1 plays a large role in determining the clearance or chronicity after hepatitis B virus (HBV) exposure. However, it is not clear whether type I interferon receptor-1 (IFNAR-1) variations continuously exert their effects to influence the final outcomes following HBV chronicity, including a...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0102
更新日期:2010-06-01 00:00:00
abstract::Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282403322017929
更新日期:2003-01-01 00:00:00
abstract::Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0102
更新日期:2020-10-05 00:00:00
abstract::Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1994.7.155
更新日期:1994-01-01 00:00:00
abstract::The ability of a highly divergent antigenic site of foot-and-mouth disease virus (FMDV) of serotype C to elicit neutralizing antibodies has been evaluated in mice and rabbits. The viruses compared, FMDV C-S8c1 and HR, differ in a single amino acid replacement in their capsid proteins, but represent two extreme antigen...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1995.8.11
更新日期:1995-01-01 00:00:00
abstract::The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA an...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1992.5.229
更新日期:1992-10-01 00:00:00
abstract::Most strategies for reducing global measles morbidity and mortality and eliminating measles are based on the ability to enhance immune responses to measles virus. Challenges to measles elimination and eradication are based in part on the need to sustain high levels of population immunity to interrupt transmission of m...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/08828240152716556
更新日期:2001-01-01 00:00:00
abstract::Yellow fever is a zoonotic disease caused by the yellow fever virus (YFV) and transmitted by mosquitoes of the family Culicidae. It is well known that cellular and viral microRNAs (miRNAs) are involved in modulation of viral and cellular gene expression, as well as immune response, and are considered by the scientific...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0149
更新日期:2017-06-01 00:00:00
abstract::The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...
journal_title:Viral immunology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1089/vim.2014.0094
更新日期:2015-04-01 00:00:00
abstract::Subacute sclerosing panencephalitis (SSPE) is caused by a persistent measles virus infection. Regulatory mechanisms can be responsible for a failure of immunosurveillance in children with SSPE. In this study, peripheral blood cells of 71 patients with SSPE and 57 children with other diseases were compared phenotypical...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0070
更新日期:2014-12-01 00:00:00
abstract::The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.162
更新日期:2005-01-01 00:00:00
abstract::The implications of sequential prime and challenge with mismatched influenza A viruses is a concern in mammals, including humans. We evaluated the ability of pigs affected with vaccine-associated enhanced respiratory disease (VAERD) to generate a humoral immune response against the heterologous challenge virus incitin...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0018
更新日期:2013-10-01 00:00:00
abstract::Hepatitis C virus (HCV) signifies an important health issue as it is a globally prevalent pathogen and poses a great threat to human health. Direct antiviral therapy became a landmark in treatment against chronic HCV infection as they have proven to increase sustained virological response (SVR) rate, provide shortened...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0124
更新日期:2018-04-01 00:00:00
abstract::Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclon...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2004.17.440
更新日期:2004-01-01 00:00:00
abstract::Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0041
更新日期:2007-09-01 00:00:00
abstract::Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infecti...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2007.0013
更新日期:2007-07-01 00:00:00