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Immunological characterization of respiratory syncytial virus N protein epitopes recognized by human cytotoxic T lymphocytes.

Abstract：

:Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying three peptides designated as N-RSV1, N-RSV2, and N-RSV3. These peptides were used to generate CTL lines by stimulating human HLA-A 02.01 peripheral blood mononuclear cells (PBMCs) in vitro. These CTL lines were then characterized by performing CTL chromium release assays and IFN-gamma secretion detection by intracellular cytokine staining. N-RSV1 and N-RSV3 peptides elicited the strongest cytolytic activity against RSV-infected cells and they could be useful epitopes for the analysis of CTL responses to RSV and for understanding immune-induced disease pathogenesis.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

doi

10.1089/vim.2007.0041

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

399-406

issue

3

eissn

0882-8245

issn

1557-8976

journal_volume

20

pub_type

杂志文章

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