当前位置： SCI文献检索 > VIRAL IMMUNOLOGY期刊下所有文献 > NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients.

NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients.

Abstract：

:Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC function and the presence of ADCC antibodies in plasma from 20 HIV-1-infected patients and 10 healthy donors. The HIV-positive patients were divided into two groups: six who controlled viremia for at least 8 y without treatment (controllers), and 14 who were persistently viremic and not currently on treatment. Plasma from both patient groups induced NK cell IFN-γ expression and degranulation in response to HIV-1 envelope (Env) gp140-protein-coated cells. Patient antibodies mediating ADCC were largely directed towards the Env V3 loop, as identified by a gp140 protein lacking the V3 loop. Interestingly, in two controllers ADCC-mediating antibodies were more broadly directed to other parts of Env. A high viral load in patients correlated with decreased ADCC-mediated cytolysis of gp140-protein-coated target cells. NK cells from both infected patients and healthy donors degranulated efficiently in the presence of antibody-coated HIV-1-infected Jurkat cells. In conclusion, the character of ADCC-mediating antibodies differed in some controllers compared to viremic patients. NK cell ADCC activity is not compromised in HIV-infected patients.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Johansson SE,Rollman E,Chung AW,Center RJ,Hejdeman B,Stratov I,Hinkula J,Wahren B,Kärre K,Kent SJ,Berg L

doi

10.1089/vim.2011.0025

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

359-68

issue

5

eissn

0882-8245

issn

1557-8976

journal_volume

24

pub_type

杂志文章

相关文献

VIRAL IMMUNOLOGY文献大全
  • Varicella zoster virus-specific cytotoxicity following secondary immunization with live or killed vaccine.

    abstract：:Subjects > or = 55 years of age were immunized with attenuated varicella zoster virus (VZV) vaccine (live) or with the same vaccine, which had been heated to 56 degrees C for 7 days (killed). The ability of subjects' blood lymphocytes to lyse target cells infected with VZV was determined before and 3 months after immu...

    journal_title：Viral immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1089/vim.1996.9.241

    authors： Hayward AR,Buda K,Jones M,White CJ,Levin MJ

    更新日期：1996-01-01 00:00:00

  • Endogenous retroviral gp70 genes of the murine lymphoma L5178Y: analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity.

    abstract：:Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1994.7.155

    authors： Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

    更新日期：1994-01-01 00:00:00

  • Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27.

    abstract：:Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1995.8.53

    authors： Manickan E,Yu Z,Rouse RJ,Wire WS,Rouse BT

    更新日期：1995-01-01 00:00:00

  • Monoclonal antibodies to bluetongue virus define two neutralizing epitopes and a hemagglutinating epitope.

    abstract：:Monoclonal antibodies were used to characterize neutralizing epitopes on VP2 of bluetongue virus serotype 10 (BTV-10). Six neutralizing monoclonal antibodies that immune precipitated VP2 demonstrated two distinct patterns of reactivity in the competitive enzyme-linked immune absorbent assay (ELISA). These results sugg...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1990.3.161

    authors： Mecham JO,Jochim MM

    更新日期：1990-07-01 00:00:00

  • Safety and Efficacy Profile of Live, Intermediate Plus Vaccine Against Infectious Bursal Disease Based on Strain G6.

    abstract：:Infectious bursal disease (IBD) is an acute, highly contagious, immunosuppressive disease of young chickens that causes considerable economic loss in the poultry industry worldwide. Vaccination with live attenuated vaccines is still the most important method used for the control and prevention of IBD in chickens. Here...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2020.0204

    authors： Huić Babić K,Ljuma Skupnjak L,Zorman Rojs O,Halas M,Vrdoljak A

    更新日期：2021-01-28 00:00:00

  • To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

    abstract：:As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/088282402317340260

    authors： He Y,Katze MG

    更新日期：2002-01-01 00:00:00

  • Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells.

    abstract：:The objective of this study was to investigate the immune responses elicited by either a modified-live (MLV) or a killed virus (KV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Specifically, we investigated the effects of multiple vaccinations on antigen-specific cellular and antibody responses...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282404322875430

    authors： Bassaganya-Riera J,Thacker BJ,Yu S,Strait E,Wannemuehler MJ,Thacker EL

    更新日期：2004-01-01 00:00:00

  • Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge.

    abstract：:We have previously demonstrated the formation and release of influenza virus-like particles (VLPs) from the surface of Sf9 cells infected with either a quadruple baculovirus recombinant that simultaneously expresses the influenza structural proteins hemagglutinin (HA), neuraminidase (NA), matrix 1 (M1) and M2, or a co...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.244

    authors： Galarza JM,Latham T,Cupo A

    更新日期：2005-01-01 00:00:00

  • The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

    abstract：:We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2011.0091

    authors： Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

    更新日期：2012-06-01 00:00:00

  • The effect of different bovine viral diarrhea virus genotypes and biotypes on the metabolic activity and activation status of bovine peripheral blood mononuclear cells.

    abstract：:The effects of cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) on the cellular metabolic activity and activation status of bovine peripheral blood mononuclear cells (PBMC) were investigated. Cellular DNA and protein synthesis was determined by [3H]thymidine and [3H]valine incorporation, res...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1998.11.233

    authors： Hou L,Wilkerson M,Kapil S,Mosier D,Shuman W,Reddy JR,Loughin T,Minocha HC

    更新日期：1998-01-01 00:00:00

  • Enhanced CD103 Expression and Reduced Frequencies of Virus-Specific CD8+ T Cells Among Airway Lymphocytes After Influenza Vaccination of Mice Deficient in Vitamins A + D.

    abstract：:Previous research has evaluated antibody responses toward an influenza virus vaccine in the context of deficiencies for vitamins A and D (VAD+VDD). Results showed that antibodies and antibody-forming cells in the respiratory tract were reduced in VAD+VDD mice. However, effectors were recovered when oral supplements of...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0086

    authors： Surman SL,Jones BG,Woodland DL,Hurwitz JL

    更新日期：2017-12-01 00:00:00

  • Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression.

    abstract：:Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282402320914539

    authors： Gopinath RS,Ambagala AP,Hinkley S,Srikumaran S

    更新日期：2002-01-01 00:00:00

  • Induction of antihemagglutinin antibodies by polyclonal antiidiotype antibodies.

    abstract：:Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1993.6.75

    authors： Dinca L,Neuwirth S,Schulman J,Bona C

    更新日期：1993-04-01 00:00:00

  • Plasmid expressing the influenza HA gene protects old mice from lethal challenge with influenza virus.

    abstract：:Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with pla...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1999.12.217

    authors： Radu DL,Antohi S,Bot A,Weksler ME,Bona C

    更新日期：1999-01-01 00:00:00

  • gamma-Herpesvirus-induced protection against bacterial infection is transient.

    abstract：:Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically s...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2008.0086

    authors： Yager EJ,Szaba FM,Kummer LW,Lanzer KG,Burkum CE,Smiley ST,Blackman MA

    更新日期：2009-02-01 00:00:00

  • Role of Some Predominant Host Immunomodulators' Single Nucleotide Polymorphisms in Severity of Hepatitis B Virus and Hepatitis C Virus Infection.

    abstract：:Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2016.0062

    authors： Rehman SU,Rauf M,Abbas Z,Hamed MH,Qadri I

    更新日期：2016-12-01 00:00:00

  • Correlation of in vitro T-cell and B-cell function with responses to childhood vaccines in children with human immunodeficiency virus infection.

    abstract：:We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1997.10.197

    authors： Peters VB,Mayer LF,Sperber KE

    更新日期：1997-01-01 00:00:00

  • Impaired mitogen-driven proliferation and cytokine transcription of lymphocytes from macaques early after simian immunodeficiency virus (SIV) infection.

    abstract：:Altered cytokine transcription might play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection in humans. The infection of rhesus macaques with simian immunodeficiency virus (SIV) provides a relevant animal model for HIV infection. Therefore, we evaluated the cyokine transcription of p...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1997.10.65

    authors： Spring M,Bodemer W,Stahl-Hennig C,Nisslein T,Hunsmann G,Dittmer U

    更新日期：1997-01-01 00:00:00

  • Effects of different immunization protocols and adjuvant on antibody responses to inactivated SARS-CoV vaccine.

    abstract：:Severe acute respiratory syndrome (SARS) is a deadly and highly infectious disease caused by SARS Coronavirus (SARS-CoV). Inactivated SARS-CoV has been explored as a vaccine against SARS-CoV; however, current knowledge of inactivated SARS-CoV vaccine is quite limited. We attempted to investigate the effects of differe...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0079

    authors： Gai W,Zou W,Lei L,Luo J,Tu H,Zhang Y,Wang K,Tien P,Yan H

    更新日期：2008-03-01 00:00:00

  • The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus.

    abstract：:Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0098

    authors： Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

    更新日期：2018-05-01 00:00:00

  • Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression.

    abstract：:Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2013.0127

    authors： Liu Y,Zhang Z,Zhao X,Yu R,Zhang X,Wu S,Liu J,Chi X,Song X,Fu L,Yu Y,Hou L,Chen W

    更新日期：2014-08-01 00:00:00

  • Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy.

    abstract：:Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2018.0014

    authors： Ariyanto IA,Estiasari R,Waters S,Wulandari EAT,Fernandez S,Lee S,Price P

    更新日期：2018-07-01 00:00:00

  • Autoantibody idiotypy and neonatal B cell repertoire.

    abstract：:During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.1989.2.263

    authors： Sollazzo M,Glotz D,Castiglia D,Zanetti M

    更新日期：1989-01-01 00:00:00

  • Von Willebrand factor is elevated in individuals infected with Sudan virus and is associated with adverse clinical outcomes.

    abstract：:Sudan virus (SUDV) is a member of the Filoviridae family that has been associated with sporadic outbreaks of human disease in sub-Saharan Africa. The filoviruses are notable for the high frequencies with which they cause both hemorrhagic manifestations and death in infected individuals. Recently, we reported an extens...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0072

    authors： McElroy AK,Erickson BR,Flietstra TD,Rollin PE,Towner JS,Nichol ST,Spiropoulou CF

    更新日期：2015-02-01 00:00:00

  • Antibody-binding epitope differences in the nucleoprotein of avian and mammalian influenza A viruses.

    abstract：:Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2010.0088

    authors： Varich NL,Sadykova GK,Prilipov AG,Kochergin-Nikitsky KS,Kushch AA,Masalova OV,Klimova RR,Gitelman AK,Kaverin NV

    更新日期：2011-04-01 00:00:00

  • Replicon Particle Expressing the E2 Glycoprotein of Bovine Viral Diarrhea Virus Immunization and Evaluation of Antibody Response.

    abstract：:The objective of this study was to develop a new antigen delivery system using an alphavirus replicon particle (RP) to induce humoral antibody responses against bovine viral diarrhea virus (BVDV) recombinant antigen produced from envelope glycoprotein E2. An alphavirus RP expressing the E2 glycoprotein of BVDV was use...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0053

    authors： Hossain MM,Rowland RR

    更新日期：2018-01-01 00:00:00

  • Comparison of antibody- and cell-mediated immune responses after intramuscular hepatitis C immunizations of BALB/c mice.

    abstract：:Current treatments for hepatitis C infection have limited efficacy, and there is no vaccine available. The goal of this study was to compare the immune response to several immunization combinations against hepatitis C virus (HCV). Six groups of mice were immunized at weeks 0, 4, and 8 with different combinations of a ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.637

    authors： Ghorbani M,Nass T,Azizi A,Soare C,Aucoin S,Giulivi A,Anderson DE,Diaz-Mitoma F

    更新日期：2005-01-01 00:00:00

  • Demonstration of the in vitro antiviral properties of bovine lymphokine-activated killer (LAK) cells.

    abstract：:In cattle, cells with functional characteristics similar to those of natural killer (NK) cells are difficult to detect. However, lymphokine-activated killer (LAK) cells can be detected readily after in vitro activation of peripheral blood mononuclear leukocytes (PBML) with interleukin-2 (IL-2). In the present study, w...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1991.4.259

    authors： Campos M,Ohmann HB,Rapin N,Babiuk LA

    更新日期：1991-01-01 00:00:00

  • A decrease of regulatory T cells and altered expression of NK receptors are observed in subacute sclerosing panencephalitis.

    abstract：:Subacute sclerosing panencephalitis (SSPE) is caused by a persistent measles virus infection. Regulatory mechanisms can be responsible for a failure of immunosurveillance in children with SSPE. In this study, peripheral blood cells of 71 patients with SSPE and 57 children with other diseases were compared phenotypical...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0070

    authors： Yentur SP,Gurses C,Demirbilek V,Adin-Cinar S,Kuru U,Uysal S,Yapici Z,Yilmaz G,Cokar O,Onal E,Gökyigit A,Saruhan-Direskeneli G

    更新日期：2014-12-01 00:00:00

  • Adenoviral vectors for mucosal vaccination against infectious diseases.

    abstract：:Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2005.18.283

    authors： Santosuosso M,McCormick S,Xing Z

    更新日期：2005-01-01 00:00:00