Abstract:
:Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with plasmids expressing the HA gene induced comparable clearance of influenza virus from the lungs and the same level of protection from a lethal challenge with live WSN influenza virus. Thus, genetic immunization may offer advantages for the elderly over virus-base vaccines.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Radu DL,Antohi S,Bot A,Weksler ME,Bona Cdoi
10.1089/vim.1999.12.217subject
Has Abstractpub_date
1999-01-01 00:00:00pages
217-26issue
3eissn
0882-8245issn
1557-8976journal_volume
12pub_type
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