Anti-idiotypic antibodies to feline leukemia virus: an approach for retroviral immunization strategies.


:The present study describes an approach to the development and use of anti-idiotypic antibodies as a possible immunization strategy to prevent retroviral infection. The rationale for using anti-idiotypes (anti-Ids) to try to elicit an antigenic-specific immune response is examined, and the production and characterization of polyclonal and monoclonal anti-Ids are described. Several techniques were used to determine antigenic mimicry and anti-Id subtypes. The potential use of anti-Ids in feline leukemia virus (FeLV) receptor studies and vaccine trials in vivo were investigated. Results from these studies suggest that the anti-Id strategy is feasible for the FeLV model. Polyclonal Ab2 reagents were developed that blocked virus-receptor binding and thus inhibited viral infection in vitro and induced humoral immune responses in 6- to 8-week old kittens characterized by production of Ab3 with the ability to bind the original FeLV envelope protein gp70 as assessed by Western blot analysis.


Viral Immunol


Viral immunology


Tavares L,Roneker C,Postie L,Fevereiro M,de Noronha F




Has Abstract


1991-04-01 00:00:00












  • Immunological characterization of respiratory syncytial virus N protein epitopes recognized by human cytotoxic T lymphocytes.

    abstract::Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

    更新日期:2007-09-01 00:00:00

  • Fowl Aviadenovirus 9 dUTPase Plays a Role in Regulation of the Host Immune Response.

    abstract::Fowl aviadenoviruses (FAdVs) are distributed worldwide in poultry farms. Some FAdVs are the causative agents of inclusion body hepatitis and hydropericardium syndrome that cause significant economic losses to the poultry industry. In contrast with human adenovirus, the study of the molecular biology of FAdV is still f...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Deng L,Griffin BD,Pei Y,Leishman D,McBey BA,Sharif S,Nagy É

    更新日期:2017-11-01 00:00:00

  • Detection of genetic diversity among bovine immunodeficiency virus population by single-strand conformation polymorphism analysis.

    abstract::Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Kalvatchev Z,Walder R,Garzaro D,Barrios M

    更新日期:2000-01-01 00:00:00

  • Characterization of Anti-HCV Antibodies in IL-10-Treated Patients.

    abstract::There is limited information on the direct role of the neutralizing antibody responses against hepatitis C virus (HCV) infection or methodologies to study them. Previously we have demonstrated that interleukin-10 (IL-10) administered to chronic hepatitis patients led to a decrease in disease activity, but an increase ...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Eksioglu EA,Bess J,Jones G,Dettloff J,Dangmeon P,Dong HJ,Zhu H,Firpi R,Xu Y,Nelson DR,Liu C

    更新日期:2010-08-01 00:00:00

  • The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza.

    abstract::Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Smith AM,Huber VC

    更新日期:2018-03-01 00:00:00

  • Identification of an immunodominant peptide in the parvovirus B19 VP1 unique region able to elicit a long-lasting immune response in humans.

    abstract::The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Zuffi E,Manaresi E,Gallinella G,Gentilomi GA,Venturoli S,Zerbini M,Musiani M

    更新日期:2001-01-01 00:00:00

  • Antibody-dependent enhancement of virus infection and disease.

    abstract::In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infec...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Tirado SM,Yoon KJ

    更新日期:2003-01-01 00:00:00

  • Apparent requirement for CD4+ T cells in primary anti-herpes simplex virus cytotoxic T-lymphocyte induction can be overcome by optimal antigen presentation.

    abstract::Mice depleted in vivo of either CD4+ or CD8+ T cells were used to define the requirement for interaction between the two T subsets for the induction and maturation of a herpes simplex virus (HSV) cytotoxic T-lymphocyte (CTL) response. Whereas C3H mice generated normal CD8+ CTL in the absence of CD4+ T cells, responses...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Mercadal CM,Martin S,Rouse BT

    更新日期:1991-10-01 00:00:00

  • Regulation of microbial immunity: the suppressor cell renaissance.

    abstract::Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to mi...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Suvas S,Rouse BT

    更新日期:2005-01-01 00:00:00

  • Double-Stranded Ribonucleic Acid-Mediated Antiviral Response Against Low Pathogenic Avian Influenza Virus Infection.

    abstract::Toll-like receptor (TLR)3 signaling pathway is known to induce type 1 interferons (IFNs) and proinflammatory mediators leading to antiviral response against many viral infections. Double-stranded ribonucleic acid (dsRNA) has been shown to act as a ligand for TLR3 and, as such, has been a focus as a potential antiviral...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Ahmed-Hassan H,Abdul-Cader MS,Ahmed Sabry M,Hamza E,Sharif S,Nagy E,Abdul-Careem MF

    更新日期:2018-07-01 00:00:00

  • Development of a Time and Cost Benefit Antibody Binding Test-Based Method for Determination of Rabies Vaccine Potency.

    abstract::This study is an improvement on the antibody binding test, known as ABT method, to develop a simple and fast method in comparison with NIH for determination of rabies vaccine potency. In the current study, several commercial human and veterinary vaccines were tested using both modified ABT and NIH methods. The ED50 wa...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Asgary V,Mojtabavi N,Janani A,Mousavi T,Hadjati J,Khosravy MS,Ahangari Cohan R

    更新日期:2017-04-01 00:00:00

  • Efficacy of modified levamisole adjuvant on inactivated virus vaccine.

    abstract::To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Yin J,Jin H,Kang Y,Xiao C,Zhao L,Li X,Ding Z,Yang F,Zhu Q,Wang B

    更新日期:2006-07-01 00:00:00

  • Induction of cytotoxic T lymphocytes of heterogeneous specificities by immunization with a single peptide derived from influenza A virus.

    abstract::We examined whether immunization with a single peptide induces cytotoxic T lymphocytes (CTLs) of heterogeneous specificities in vivo. Immunization of BALB/c mice with the peptide H2:529-537, which corresponded to amino acid residues 529-537 on the HA2 subunit transmembrane region of influenza A/Jap virus (H2N2) and po...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Masaki H,Tamura M,Kurane I

    更新日期:2000-01-01 00:00:00

  • The effect of different bovine viral diarrhea virus genotypes and biotypes on the metabolic activity and activation status of bovine peripheral blood mononuclear cells.

    abstract::The effects of cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) on the cellular metabolic activity and activation status of bovine peripheral blood mononuclear cells (PBMC) were investigated. Cellular DNA and protein synthesis was determined by [3H]thymidine and [3H]valine incorporation, res...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Hou L,Wilkerson M,Kapil S,Mosier D,Shuman W,Reddy JR,Loughin T,Minocha HC

    更新日期:1998-01-01 00:00:00

  • A small animal model for mother-to-fetus transmission of ts1, a murine retrovirus.

    abstract::Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Chakraborty J,Clark S,Okonta H,Duggan J

    更新日期:2003-01-01 00:00:00

  • Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin.

    abstract::Highly pathogenic avian influenza (HPAI) H5N1 virus emerged in 1997 as a zoonotic disease in Hong Kong. It has since spread to Asia and Europe and is a serious threat to both the poultry industry and human health. For effective surveillance and possible prevention/control of HPAI H5N1 viruses, it is necessary to under...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Daidoji T,Watanabe Y,Arai Y,Kajikawa J,Hirose R,Nakaya T

    更新日期:2017-07-01 00:00:00

  • Endogenous retroviral gp70 genes of the murine lymphoma L5178Y: analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity.

    abstract::Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

    更新日期:1994-01-01 00:00:00

  • Major Immunodominant Region of Hepatitis B Virus Core Antigen as a Delivery Vector to Improve the Immunogenicity of the Fusion Antigen ROP2-SAG1 Multiepitope from Toxoplasma gondii in Mice.

    abstract::To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR),...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Wang W,Feng F,Lv J,Xie Z,Chen J,Zhang L,Li W

    更新日期:2017-09-01 00:00:00

  • COVID-19: Between Past and Present.

    abstract::Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Assaf AM,Haddadin RN,Akour AA

    更新日期:2020-10-05 00:00:00

  • Role of Some Predominant Host Immunomodulators' Single Nucleotide Polymorphisms in Severity of Hepatitis B Virus and Hepatitis C Virus Infection.

    abstract::Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Rehman SU,Rauf M,Abbas Z,Hamed MH,Qadri I

    更新日期:2016-12-01 00:00:00

  • The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice.

    abstract::Immunization with hepatitis B vaccine is an effective measure for prevention and control of hepatitis B Virus (HBV) infection. Although lots of efforts to improve the effect of hepatitis B vaccine have been made, the function of human beta defensin 2 (hBD2) on hepatitis B vaccine keeps unclear. In this article, we rep...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Wang M,Zeng W,Zhang Z,Zhang W,Su H,Zhang Z,Jiang L,Liu Y,Shi Q

    更新日期:2020-12-28 00:00:00

  • Induction of immunity in the respiratory tract and protection from bovine herpesvirus type 1 infection by different routes of immunization with recombinant adenovirus.

    abstract::To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Papp Z,Babiuk LA,Baca-Estrada ME

    更新日期:1998-01-01 00:00:00

  • Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles.

    abstract::Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Peretz Y,Marra O,Thomas R,Legault D,Côté P,Boulassel MR,Rouleau D,Routy JP,Sékaly RP,Tsoukas CM,Tremblay C,Bernard NF

    更新日期:2011-06-01 00:00:00

  • Protein A-based ELISA: its evaluation in the diagnosis of herpes simplex encephalitis.

    abstract::Herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, early rapid and reliable diagnosis has become important. The objective of the present study was to develop a sensitive enzyme-linked immunosorbent assay (EL...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Bhullar SS,Kashyap RS,Chandak NH,Purohit HJ,Taori GM,Daginawala HF

    更新日期:2011-08-01 00:00:00

  • Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.

    abstract::Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Gruber A,Chalmers AS,Rasmussen RA,Ong H,Popov S,Andersen J,Hu SL,Ruprecht RM

    更新日期:2007-04-01 00:00:00

  • Correlation of in vitro T-cell and B-cell function with responses to childhood vaccines in children with human immunodeficiency virus infection.

    abstract::We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Peters VB,Mayer LF,Sperber KE

    更新日期:1997-01-01 00:00:00

  • Association of a TANK gene polymorphism with outcomes of hepatitis B virus infection in a Chinese Han population.

    abstract::The host genetic compound plays a vital role in determining clinical outcomes of hepatitis B virus (HBV) infection. The tumor necrosis factor receptor-associated factor family member-associated nuclear factor-κB (NF-κB) activator (TANK) takes part in the tumor necrosis factor-α (TNF-α)-mediated NF-κB signaling pathway...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Song QL,He XX,Yang H,Li J,Chen M,Wang MY,Liu Q,Yu JL,Yao JJ,Liu LF,Sun SZ,Lin JS

    更新日期:2012-02-01 00:00:00

  • Prion diseases and the spleen.

    abstract::Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy and scrapie in sheep and goats. Transmissible spongiform encephalopathies are thought by some to result from changes in the conformation of a membrane glyco...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Daude N

    更新日期:2004-01-01 00:00:00

  • Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009.

    abstract::The implications of sequential prime and challenge with mismatched influenza A viruses is a concern in mammals, including humans. We evaluated the ability of pigs affected with vaccine-associated enhanced respiratory disease (VAERD) to generate a humoral immune response against the heterologous challenge virus incitin...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Gauger PC,Loving CL,Lager KM,Janke BH,Kehrli ME Jr,Roth JA,Vincent AL

    更新日期:2013-10-01 00:00:00

  • The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

    abstract::We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

    更新日期:2012-06-01 00:00:00