Abstract：
:The present study describes an approach to the development and use of anti-idiotypic antibodies as a possible immunization strategy to prevent retroviral infection. The rationale for using anti-idiotypes (anti-Ids) to try to elicit an antigenic-specific immune response is examined, and the production and characterization of polyclonal and monoclonal anti-Ids are described. Several techniques were used to determine antigenic mimicry and anti-Id subtypes. The potential use of anti-Ids in feline leukemia virus (FeLV) receptor studies and vaccine trials in vivo were investigated. Results from these studies suggest that the anti-Id strategy is feasible for the FeLV model. Polyclonal Ab2 reagents were developed that blocked virus-receptor binding and thus inhibited viral infection in vitro and induced humoral immune responses in 6- to 8-week old kittens characterized by production of Ab3 with the ability to bind the original FeLV envelope protein gp70 as assessed by Western blot analysis.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Tavares L,Roneker C,Postie L,Fevereiro M,de Noronha Fdoi
10.1089/vim.1991.4.5subject
Has Abstractpub_date
1991-04-01 00:00:00pages
5-16issue
1eissn
0882-8245issn
1557-8976journal_volume
4pub_type
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