Antibody to dengue 1 detected more than 60 years after infection.

abstract：:Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...

journal_title：Viral immunology

authors： Rehman SU,Rauf M,Abbas Z,Hamed MH,Qadri I

更新日期：2016-12-01 00:00:00

abstract：:Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. In this study, we explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy fo...

journal_title：Viral immunology

authors： Hallengärd D,Wahren B,Bråve A

更新日期：2013-04-01 00:00:00

abstract：:Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...

journal_title：Viral immunology

authors： Chakraborty J,Clark S,Okonta H,Duggan J

更新日期：2003-01-01 00:00:00

abstract：:Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...

journal_title：Viral immunology

authors： Liang SH,Rieber P,Prewett M,Riethmüller G,Pletcher C,Hoxie J,Koprowski H,Herlyn D

更新日期：1991-07-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...

journal_title：Viral immunology

authors： Peretz Y,Marra O,Thomas R,Legault D,Côté P,Boulassel MR,Rouleau D,Routy JP,Sékaly RP,Tsoukas CM,Tremblay C,Bernard NF

更新日期：2011-06-01 00:00:00

abstract：:To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...

journal_title：Viral immunology

authors： Kumar SR,Biswas M,Elankumaran S

更新日期：2014-04-01 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...

journal_title：Viral immunology

authors： Alhetheel A,Altalhi H,Albarrag A,Shakoor Z,Mohamed D,El-Hazmi M,Somily A,Barry M,Bakhrebah M,Nassar M

更新日期：2017-11-01 00:00:00

abstract：:Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immuni...

journal_title：Viral immunology

authors： Hofstetter AR,Evavold BD,Lukacher AE

更新日期：2013-02-01 00:00:00

abstract：:The ability of a highly divergent antigenic site of foot-and-mouth disease virus (FMDV) of serotype C to elicit neutralizing antibodies has been evaluated in mice and rabbits. The viruses compared, FMDV C-S8c1 and HR, differ in a single amino acid replacement in their capsid proteins, but represent two extreme antigen...

journal_title：Viral immunology

authors： Borrego B,Camarero JA,Mateu MG,Domingo E

更新日期：1995-01-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 5 (GP5) is the most abundant envelope glycoprotein and a key target for neutralizing antibodies. Previous studies have demonstrated that the native GP5 glycoprotein is poorly immunogenic and not able to induce robust protective responses, probabl...

journal_title：Viral immunology

authors： Wu F,Peng K,Tian J,Xu X,Zhou E,Chen H

更新日期：2014-09-01 00:00:00

abstract：:Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN...

journal_title：Viral immunology

authors： Rodriguez JJ,Horvath CM

更新日期：2004-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...

journal_title：Viral immunology

authors： Liu Y,Zhang Z,Zhao X,Yu R,Zhang X,Wu S,Liu J,Chi X,Song X,Fu L,Yu Y,Hou L,Chen W

更新日期：2014-08-01 00:00:00

abstract：:CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...

journal_title：Viral immunology

authors： Srikiatkhachorn A,Chintapalli J,Liu J,Jamaluddin M,Harrod KS,Whitsett JA,Enelow RI,Ramana CV

更新日期：2010-12-01 00:00:00

abstract：:Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication ef...

journal_title：Viral immunology

authors： Hao C,Wang J,Kang W,Xie Y,Zhou Y,Ma L,Peng M,Bai X,Lian J,Jia Z

更新日期：2013-10-01 00:00:00

abstract：:Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...

journal_title：Viral immunology

authors： Piras F,Bollard S,Laval F,Joisel F,Reynaud G,Charreyre C,Andreoni C,Juillard V

更新日期：2005-01-01 00:00:00

abstract：:Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in ...

journal_title：Viral immunology

authors： Diwaker D,Mishra KP,Ganju L,Singh SB

更新日期：2015-04-01 00:00:00

abstract：:California (CAL) serogroup Bunyaviruses are significant agents of arboviral encephalitis in humans. They are maintained and transmitted in nature by mosquitoes to preferred vertebrate amplifying hosts. The G2 envelope glycoprotein of La Crosse virus (LAC) was proposed by Ludwig et al. to be a determinant for virus att...

journal_title：Viral immunology

authors： Cheng LL,Schultz KT,Yuill TM,Israel BA

更新日期：2000-01-01 00:00:00

abstract：:We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

journal_title：Viral immunology

authors： Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

更新日期：2012-06-01 00:00:00

abstract：:Herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, early rapid and reliable diagnosis has become important. The objective of the present study was to develop a sensitive enzyme-linked immunosorbent assay (EL...

journal_title：Viral immunology

authors： Bhullar SS,Kashyap RS,Chandak NH,Purohit HJ,Taori GM,Daginawala HF

更新日期：2011-08-01 00:00:00

abstract：:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

journal_title：Viral immunology

authors： Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

更新日期：2005-01-01 00:00:00

abstract：:Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...

journal_title：Viral immunology

authors： Sarkar AK,Tortolero-Luna G,Nehete PN,Arlinghaus RB,Mitchell MF,Sastry KJ

更新日期：1995-01-01 00:00:00

abstract：:This study was aimed at investigating the genes that control host responses to Marek's disease virus (MDV). Spleen tissues from infected and age-matched uninfected control chickens were examined 4, 7, 14, and 21 d postinfection for gene expression differences, using both microarray and quantitative real-time polymeras...

journal_title：Viral immunology

authors： Sarson AJ,Abdul-Careem MF,Zhou H,Sharif S

更新日期：2006-01-01 00:00:00

abstract：:Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...

journal_title：Viral immunology

authors： Omran D,Zayed RA,Nabeel MM,Mobarak L,Zakaria Z,Farid A,Hassany M,Saif S,Mostafa M,Saad OK,Yosry A

更新日期：2018-05-01 00:00:00

abstract：:C57BL/6 mice can generate a type-specific and class IH-2Kb-restricted CTL response against histocompatible AKR/Gross murine leukemia virus (MuLV) cell surface antigen positive (GCSA+) tumor cells. These anti-AKR/Gross MuLV CTL are also known to lyse SC.Kb/623 target cells expressing the molecular MuLV clone AKR623 (de...

journal_title：Viral immunology

authors： White HD,Roeder DA,Lam T,Green WR

更新日期：1994-01-01 00:00:00

abstract：:Mice depleted in vivo of either CD4+ or CD8+ T cells were used to define the requirement for interaction between the two T subsets for the induction and maturation of a herpes simplex virus (HSV) cytotoxic T-lymphocyte (CTL) response. Whereas C3H mice generated normal CD8+ CTL in the absence of CD4+ T cells, responses...

journal_title：Viral immunology

authors： Mercadal CM,Martin S,Rouse BT

更新日期：1991-10-01 00:00:00

abstract：:To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...

journal_title：Viral immunology

authors： Papp Z,Babiuk LA,Baca-Estrada ME

更新日期：1998-01-01 00:00:00

abstract：:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...

journal_title：Viral immunology

authors： Komatsu T,Barna M,Reiss CS

更新日期：1997-01-01 00:00:00

abstract：:Bacterial flagellin is a potent adjuvant that enhances adaptive immune responses to a variety of protein antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore we evaluated the humoral res...

journal_title：Viral immunology

authors： Delaney KN,Phipps JP,Johnson JB,Mizel SB

更新日期：2010-04-01 00:00:00

abstract：:Studies of immune function in human immunodeficiency virus (HIV)-infected children are important, because functional abnormalities can precede CD4+ T-cell loss and are associated with the development of opportunistic and bacterial infections. We sought to correlate clinical parameters and immunological function with H...

journal_title：Viral immunology

authors： Peters VB,Mayer L,Sperber KE

更新日期：1999-01-01 00:00:00

abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

journal_title：Viral immunology

authors： Phillips TR,Schultz RD

更新日期：1987-01-01 00:00:00