Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling.


:Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN-responsive STAT proteins. Hendra virus and Nipah virus (Henipaviruses) are recently emerged paramyxoviruses that are the causative agents of fatal disease outbreaks in Australia and peninsular Malaysia. Similar to other paramyxoviruses, Henipaviruses inhibit IFN signal transduction through a virus-encoded protein called V. Recent studies have shown that Henipavirus V proteins target STAT proteins by inducing the formation of cytoplasmically localized high molecular weight STAT-containing complexes. This sequestration of STAT1 and STAT2 prevents STAT activation and blocks antiviral IFN signaling. As the V proteins are important factors for host evasion, they represent logical targets for therapeutics directed against Henipavirus epidemics.


Viral Immunol


Viral immunology


Rodriguez JJ,Horvath CM




Has Abstract


2004-01-01 00:00:00












  • Better protective effects in rhesus macaques by combining systemic and mucosal application of a dual component vector vaccine after rectal SHIV89.6P challenge compared to systemic vaccination alone.

    abstract::In this study we investigated the efficacy of a multigenic DNA prime/modified vaccinia Ankara (MVA)boost vaccine approach, followed by mucosal challenge with highly pathogenic simian-human immunodeficiency virus (SHIV) 89.6P, using different routes for vaccine delivery. After three times of DNA priming (SIVmac239, Gag...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Stolte-Leeb N,Bieler K,Kostler J,Heeney J,Haaft PT,Suh YS,Hunsmann G,Stahl-Hennig C,Wagner R

    更新日期:2008-06-01 00:00:00

  • Demonstration of the in vitro antiviral properties of bovine lymphokine-activated killer (LAK) cells.

    abstract::In cattle, cells with functional characteristics similar to those of natural killer (NK) cells are difficult to detect. However, lymphokine-activated killer (LAK) cells can be detected readily after in vitro activation of peripheral blood mononuclear leukocytes (PBML) with interleukin-2 (IL-2). In the present study, w...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Campos M,Ohmann HB,Rapin N,Babiuk LA

    更新日期:1991-01-01 00:00:00

  • Analysis of Host and Viral-Related Factors Associated to Direct Acting Antiviral Response in Hepatitis C Virus Patients.

    abstract::Hepatitis C virus (HCV) signifies an important health issue as it is a globally prevalent pathogen and poses a great threat to human health. Direct antiviral therapy became a landmark in treatment against chronic HCV infection as they have proven to increase sustained virological response (SVR) rate, provide shortened...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Aziz H,Aziz M,Gill ML

    更新日期:2018-04-01 00:00:00

  • Comparison of antibody- and cell-mediated immune responses after intramuscular hepatitis C immunizations of BALB/c mice.

    abstract::Current treatments for hepatitis C infection have limited efficacy, and there is no vaccine available. The goal of this study was to compare the immune response to several immunization combinations against hepatitis C virus (HCV). Six groups of mice were immunized at weeks 0, 4, and 8 with different combinations of a ...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Ghorbani M,Nass T,Azizi A,Soare C,Aucoin S,Giulivi A,Anderson DE,Diaz-Mitoma F

    更新日期:2005-01-01 00:00:00

  • Endogenous retroviral gp70 genes of the murine lymphoma L5178Y: analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity.

    abstract::Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

    更新日期:1994-01-01 00:00:00

  • Kinetics of Th17 cytokines during telbivudine therapy in patients with chronic hepatitis B.

    abstract::Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication ef...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Hao C,Wang J,Kang W,Xie Y,Zhou Y,Ma L,Peng M,Bai X,Lian J,Jia Z

    更新日期:2013-10-01 00:00:00

  • Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27.

    abstract::Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Manickan E,Yu Z,Rouse RJ,Wire WS,Rouse BT

    更新日期:1995-01-01 00:00:00

  • Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.

    abstract::Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immuni...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Hofstetter AR,Evavold BD,Lukacher AE

    更新日期:2013-02-01 00:00:00

  • Efficacy of modified levamisole adjuvant on inactivated virus vaccine.

    abstract::To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Yin J,Jin H,Kang Y,Xiao C,Zhao L,Li X,Ding Z,Yang F,Zhu Q,Wang B

    更新日期:2006-07-01 00:00:00

  • Monoclonal antibodies to bluetongue virus define two neutralizing epitopes and a hemagglutinating epitope.

    abstract::Monoclonal antibodies were used to characterize neutralizing epitopes on VP2 of bluetongue virus serotype 10 (BTV-10). Six neutralizing monoclonal antibodies that immune precipitated VP2 demonstrated two distinct patterns of reactivity in the competitive enzyme-linked immune absorbent assay (ELISA). These results sugg...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Mecham JO,Jochim MM

    更新日期:1990-07-01 00:00:00

  • Equid herpesvirus-induced immunosuppression is associated with lymphoid cells and not soluble circulating factors.

    abstract::A paresis isolate of equid herpesvirus 1 (EHV1, Ab4/8) and a plaque-purified virus derived from it (EHV1, Ab4/13), induced long-term suppression of both mitogenic and antigen-specific lymphocyte proliferations in adult outbred ponies. Peripheral blood mononuclear cells (PBMC) taken from a pony after EHV1 infection sup...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Hannant D,O'Neill T,Ostlund EN,Kydd JH,Hopkin PJ,Mumford JA

    更新日期:1999-01-01 00:00:00

  • Evaluating Diagnostic Accuracy of Noninvasive Tests in Assessment of Significant Liver Fibrosis in Chronic Hepatitis C Egyptian Patients.

    abstract::Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Omran D,Zayed RA,Nabeel MM,Mobarak L,Zakaria Z,Farid A,Hassany M,Saif S,Mostafa M,Saad OK,Yosry A

    更新日期:2018-05-01 00:00:00

  • Regulation of microbial immunity: the suppressor cell renaissance.

    abstract::Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to mi...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Suvas S,Rouse BT

    更新日期:2005-01-01 00:00:00

  • To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

    abstract::As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: He Y,Katze MG

    更新日期:2002-01-01 00:00:00

  • Immune responses to measles and measles vaccine: challenges for measles control.

    abstract::Most strategies for reducing global measles morbidity and mortality and eliminating measles are based on the ability to enhance immune responses to measles virus. Challenges to measles elimination and eradication are based in part on the need to sustain high levels of population immunity to interrupt transmission of m...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Moss WJ,Polack FP

    更新日期:2001-01-01 00:00:00

  • Local and systemic human papillomavirus type 6b-specific cellular immune responses in patients with recurrent genital warts.

    abstract::Anogenital warts are a common clinical manifestation of genital infection with human papillomavirus type 6b (HPV-6b). Accumulating data indicate that an effective cellular immune response is required for the control of HPV infections. However, in a minority of patients there is a high rate of recurrence of wart lesion...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Blanchet JS,Sonnex C,Gough GW,Warren AP

    更新日期:2007-04-01 00:00:00

  • Mapping of B-cell epitopes in the nucleocapsid protein of Puumala hantavirus.

    abstract::Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Lundkvist A,Meisel H,Koletzki D,Lankinen H,Cifire F,Geldmacher A,Sibold C,Gött P,Vaheri A,Krüger DH,Ulrich R

    更新日期:2002-01-01 00:00:00

  • Differential Immune Responses in Mice Immunized with Recombinant Neutralizing Epitope Protein of Hepatitis E Virus Formulated with Liposome and Alum Adjuvants.

    abstract::In the developing countries, Hepatitis E virus (HEV) is a predominant cause of sporadic acute hepatitis in adults and waterborne epidemics leading to high mortality in pregnant women. Vaccine development mainly focuses on the structural capsid protein open-reading-frame-2 (ORF-2) of the virus. We successfully evaluate...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Joshi SS,Arankalle VA

    更新日期:2016-07-01 00:00:00

  • An immunodominant, cross-reactive B-cell epitope region is located at the C-terminal part of the hamster polyomavirus major capsid protein VP1.

    abstract::The VP1 represents the major capsid protein of the hamster polyomavirus (HaPV). Here we describe the mapping of epitopes along the VP1 using Escherichia coli-expressed VP1-dihydrofolate reductase (DHFR) fusion proteins and PepScan analysis. By use of DHFR fusion proteins an immunodominant region was localized in the C...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Siray H,Frömmel C,Voronkova T,Hahn S,Arnold W,Schneider-Mergener J,Scherneck S,Ulrich R

    更新日期:2000-01-01 00:00:00

  • Effects of interferon-gamma on neuronal infections.

    abstract::IFN-gamma is released in the brain, not only during acute infectious diseases or immunological reactions, but also for extended periods of time after clearance of infectious virus and during viral latency. In this review, we focus on the role of IFN-gamma in the interaction between a neuron and a pathogen, that is, th...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审


    authors: Rottenberg M,Kristensson K

    更新日期:2002-01-01 00:00:00

  • Comparison of Antigenic Dominants of VP7 in G9 and G1 Rotavirus Strains Circulating in La Rioja, Argentina, with the Vaccine Strains.

    abstract::A massive vaccination in Argentina was implemented recently. The antigenic dominants of VP7 in G9 and G1 rotavirus strains, circulating in La Rioja, Argentina with strain vaccines were compared. From 2000 to 2010 in several attention centers of La Rioja, at northwestern Argentina, 418 stool samples from children young...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Cuffia VI,Díaz Ariza Mdel C,Silvera A,Sabini LI,Cordoba PA

    更新日期:2016-07-01 00:00:00

  • Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions.

    abstract::Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 c...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Rizzo R,Gentili V,Rotola A,Bortolotti D,Cassai E,Di Luca D

    更新日期:2014-11-01 00:00:00

  • Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge.

    abstract::We have previously demonstrated the formation and release of influenza virus-like particles (VLPs) from the surface of Sf9 cells infected with either a quadruple baculovirus recombinant that simultaneously expresses the influenza structural proteins hemagglutinin (HA), neuraminidase (NA), matrix 1 (M1) and M2, or a co...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Galarza JM,Latham T,Cupo A

    更新日期:2005-01-01 00:00:00

  • A truncated plasmid-encoded HIV-1 reverse transcriptase displays strong immunogenicity.

    abstract::Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. In this study, we explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy fo...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Hallengärd D,Wahren B,Bråve A

    更新日期:2013-04-01 00:00:00

  • Mannan-binding lectin (MBL) serum concentration in relation to propagation of infectious bronchitis virus (IBV) in chickens.

    abstract::Mannan-binding lectin (MBL) is a collectin that mediates activation of the complement system and is of importance for host defenses. In humans low concentrations of MBL in serum have been associated with susceptibility to several viral diseases. To understand the function of MBL in relation to infectious viral disease...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Juul-Madsen HR,Norup LR,Handberg KJ,Jørgensen PH

    更新日期:2007-12-01 00:00:00

  • The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

    abstract::We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

    更新日期:2012-06-01 00:00:00

  • Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2.

    abstract::To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectiv...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Luo D,Ni B,Zhao G,Jia Z,Zhou L,Pacal M,Zhang L,Zhang S,Xing L,Lin Z,Wang L,Li J,Liang Y,Shi X,Zhao T,Zou L,Wu Y,Wang X

    更新日期:2007-09-01 00:00:00

  • Very virulent plus strains of MDV induce an acute form of transient paralysis in both susceptible and resistant chicken lines.

    abstract::Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly cell-associated alpha herpesvirus, Marek's disease virus (MDV). Clinical signs of MD include depression, crippling, weight loss, and transient paralysis (TP). TP is a disease of the central nervous system that affects MD-susc...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Xu M,Fitzgerald SD,Zhang H,Karcher DM,Heidari M

    更新日期:2012-08-01 00:00:00

  • Evaluation of Immunostimulatory Effects of N-(2-Hydroxy) Propyl-3-Trimethylammonium Chitosan Chloride for Improving Live Attenuated Hepatitis A Virus Vaccine Efficacy.

    abstract::This study was to evaluate the immunostimulatory effects of N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) as an adjuvant for improving a commercial live attenuated hepatitis A virus (HAV) vaccine efficacy in mice. Mice in the experimental group were intraperitoneally immunized with a solution of HT...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Tao W,Fu T,He Z,Hu R,Jia L,Hong Y

    更新日期:2017-03-01 00:00:00

  • In vivo activation of toll-like receptor-9 induces an age-dependent abortive lytic cycle reactivation of murine gammaherpesvirus-68.

    abstract::Infection of mice with murine gammaherpesvirus-68 (γHV-68) serves as a model to understand the pathogenesis of persistent viral infections, including the potential for co-infections to modulate viral latency. We have previously found that infection of neonates (8-day-old mice) with γHV-68 resulted in a high level of p...

    journal_title:Viral immunology

    pub_type: 杂志文章


    authors: Ptaschinski C,Wilmore J,Fiore N,Rochford R

    更新日期:2010-12-01 00:00:00