Studies on in vivo induction of cytotoxic T lymphocyte responses by synthetic peptides from E6 and E7 oncoproteins of human papillomavirus type 16.

abstract：:Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To ac...

journal_title：Viral immunology

authors： Takahashi Y,Onodera T,Adachi Y,Ato M

更新日期：2017-07-01 00:00:00

abstract：:Anogenital warts are a common clinical manifestation of genital infection with human papillomavirus type 6b (HPV-6b). Accumulating data indicate that an effective cellular immune response is required for the control of HPV infections. However, in a minority of patients there is a high rate of recurrence of wart lesion...

journal_title：Viral immunology

authors： Blanchet JS,Sonnex C,Gough GW,Warren AP

更新日期：2007-04-01 00:00:00

abstract：:We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...

journal_title：Viral immunology

authors： Peters VB,Mayer LF,Sperber KE

更新日期：1997-01-01 00:00:00

abstract：:Serum antibodies against the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18 are associated with cervical cancer. The aim of this study was to investigate the presence of local antibodies against HPV in cervicovaginal washings (CWs). In this study antibodies against the native HPV16 and HPV18 E6/E7 proteins...

journal_title：Viral immunology

authors： Tjiong MY,Zumbach K,Schegget JT,van der Vange N,Out TA,Pawlita M,Struyk L

更新日期：2001-01-01 00:00:00

abstract：:Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...

journal_title：Viral immunology

authors： Gopinath RS,Ambagala AP,Hinkley S,Srikumaran S

更新日期：2002-01-01 00:00:00

abstract：:Abstract IL-17 producing CD4 T cells have recently been shown to play an important role in mucosal immunity in HIV infection. But its role in peripheral immunity and the molecular mechanism underlying its regulation during HIV-1 infection are ill defined. In this study, we report a significant negative correlation b...

journal_title：Viral immunology

authors： Singh A,Vajpayee M,Ali SA,Chauhan NK

更新日期：2013-02-01 00:00:00

abstract：:Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...

journal_title：Viral immunology

authors： Askari A,Nosratabadi R,Khaleghinia M,Zainodini N,Kennedy D,Shabani Z,Kazemi Arababadi M

更新日期：2016-11-01 00:00:00

abstract：:Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...

journal_title：Viral immunology

authors： Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

更新日期：2007-09-01 00:00:00

abstract：:The present study describes an approach to the development and use of anti-idiotypic antibodies as a possible immunization strategy to prevent retroviral infection. The rationale for using anti-idiotypes (anti-Ids) to try to elicit an antigenic-specific immune response is examined, and the production and characterizat...

journal_title：Viral immunology

authors： Tavares L,Roneker C,Postie L,Fevereiro M,de Noronha F

更新日期：1991-04-01 00:00:00

abstract：:Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...

journal_title：Viral immunology

authors： Rehman SU,Rauf M,Abbas Z,Hamed MH,Qadri I

更新日期：2016-12-01 00:00:00

abstract：:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

journal_title：Viral immunology

authors： Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

更新日期：2005-01-01 00:00:00

abstract：:Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...

journal_title：Viral immunology

authors： Kalvatchev Z,Walder R,Garzaro D,Barrios M

更新日期：2000-01-01 00:00:00

abstract：:Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. In this study, we explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy fo...

journal_title：Viral immunology

authors： Hallengärd D,Wahren B,Bråve A

更新日期：2013-04-01 00:00:00

abstract：:We investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the Second World War, when dengue fever epidemics occurred throughout the Pacific and Southeast Asia. In July 1943 dengue fever reappeared in Hawaii following ...

journal_title：Viral immunology

authors： Imrie A,Meeks J,Gurary A,Sukhbaatar M,Truong TT,Cropp CB,Effler P

更新日期：2007-12-01 00:00:00

abstract：:Immunization with hepatitis B vaccine is an effective measure for prevention and control of hepatitis B Virus (HBV) infection. Although lots of efforts to improve the effect of hepatitis B vaccine have been made, the function of human beta defensin 2 (hBD2) on hepatitis B vaccine keeps unclear. In this article, we rep...

journal_title：Viral immunology

authors： Wang M,Zeng W,Zhang Z,Zhang W,Su H,Zhang Z,Jiang L,Liu Y,Shi Q

更新日期：2020-12-28 00:00:00

abstract：:The cytokine profile associated with either a T helper 1 (Th1) or Th2 response in a porcine respiratory disease model was assessed by measuring IL-12, IL-10 and IFN-gamma using RT-PCR and ELISA, respectively. IL-10, IL-12, and IFN-gamma levels in pulmonary alveolar macrophages and bronchial lavage fluid were increased...

journal_title：Viral immunology

authors： Thanawongnuwech R,Thacker EL

更新日期：2003-01-01 00:00:00

abstract：:To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...

journal_title：Viral immunology

authors： Yin J,Jin H,Kang Y,Xiao C,Zhao L,Li X,Ding Z,Yang F,Zhu Q,Wang B

更新日期：2006-07-01 00:00:00

abstract：:Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...

journal_title：Viral immunology

authors： Chakraborty J,Clark S,Okonta H,Duggan J

更新日期：2003-01-01 00:00:00

abstract：:Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections...

journal_title：Viral immunology

authors： Smith AM,Huber VC

更新日期：2018-03-01 00:00:00

abstract：:Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with pla...

journal_title：Viral immunology

authors： Radu DL,Antohi S,Bot A,Weksler ME,Bona C

更新日期：1999-01-01 00:00:00

abstract：:Infection with helper-free, defective MAIDS murine leukemia virus (MuLV) caused a rapid polyclonal activation of B cells in 0.75-, 2-, and 6-month-old C57L/J mice (H-2b, Fv-1n/n), similar to that in C57BL/6 mice (H-2b, Fv-1b/b), which was recognized by elevated plasma immunoglobulin concentrations. However, changes in...

journal_title：Viral immunology

authors： Even C,Hu B,Erickson L,Plagemann PG

更新日期：1992-04-01 00:00:00

abstract：:Fowl aviadenoviruses (FAdVs) are distributed worldwide in poultry farms. Some FAdVs are the causative agents of inclusion body hepatitis and hydropericardium syndrome that cause significant economic losses to the poultry industry. In contrast with human adenovirus, the study of the molecular biology of FAdV is still f...

journal_title：Viral immunology

authors： Deng L,Griffin BD,Pei Y,Leishman D,McBey BA,Sharif S,Nagy É

更新日期：2017-11-01 00:00:00

abstract：:The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA an...

journal_title：Viral immunology

authors： Herrmann M,Baur A,Nebel-Schickel H,Vornhagen R,Jahn G,Krapf FE,Kalden JR

更新日期：1992-10-01 00:00:00

abstract：:Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...

journal_title：Viral immunology

authors： Assaf AM,Haddadin RN,Akour AA

更新日期：2020-10-05 00:00:00

abstract：:Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...

journal_title：Viral immunology

authors： Omran D,Zayed RA,Nabeel MM,Mobarak L,Zakaria Z,Farid A,Hassany M,Saif S,Mostafa M,Saad OK,Yosry A

更新日期：2018-05-01 00:00:00

abstract：:The objective of this study was to develop a new antigen delivery system using an alphavirus replicon particle (RP) to induce humoral antibody responses against bovine viral diarrhea virus (BVDV) recombinant antigen produced from envelope glycoprotein E2. An alphavirus RP expressing the E2 glycoprotein of BVDV was use...

journal_title：Viral immunology

authors： Hossain MM,Rowland RR

更新日期：2018-01-01 00:00:00

abstract：:Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication ef...

journal_title：Viral immunology

authors： Hao C,Wang J,Kang W,Xie Y,Zhou Y,Ma L,Peng M,Bai X,Lian J,Jia Z

更新日期：2013-10-01 00:00:00

abstract：:Abstract Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate t...

journal_title：Viral immunology

authors： Baaten BJ,Staines KA,Smith LP,Skinner H,Davison TF,Butter C

更新日期：2009-12-01 00:00:00

abstract：:BALB/c mice, preimmunized with a protective dose of native herpes simplex virus type 1 glycoprotein D (ngD1) vaccine, were depleted of selected immunocyte populations in vivo using monoclonal antibodies directed at Thy1+, L3T4+, or Lyt2+ cells. Following immunization and depletion, animals were inoculated with varied ...

journal_title：Viral immunology

authors： Mishkin EM,Blasiak M,Giorgio D,Ishizaka ST

更新日期：1992-07-01 00:00:00

abstract：:One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the swit...

journal_title：Viral immunology

authors： Heltzel JMH,Gearhart PJ

更新日期：2020-05-01 00:00:00