The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice.

abstract：:Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the ...

journal_title：Viral immunology

authors： Witsø E,Cinek O,Tapia G,Rasmussen T,Stene LC,Rønningen KS

更新日期：2012-06-01 00:00:00

abstract：:Avian infectious bronchitis virus (IBV), which is prevalent in many countries causing severe economic loss to the poultry industry, causes infectious bronchitis (IB) in birds. Recombinant single-chain variable fragments (scFvs) have been proven to effectively inhibit many viruses, both in vitro and in vivo, and they c...

journal_title：Viral immunology

authors： Lin Y,Li B,Ye J,Wang M,Wang J,Zhang Y,Zhu J

更新日期：2015-09-01 00:00:00

abstract：:HIV-1 p17 is a viral cytokine that acts on preactivated, but not on resting, human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication, after binding to a cellular receptor (p17R). Here, we demonstrate that p17Rs are expressed on activated murine T cells, which respond to p17 stimu...

journal_title：Viral immunology

authors： Fiorentini S,Becker PD,Marini E,Marconi P,Avolio M,Tosti G,Link C,Manservigi R,Guzman CA,Caruso A

更新日期：2006-07-01 00:00:00

abstract：:Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...

journal_title：Viral immunology

authors： Omran D,Zayed RA,Nabeel MM,Mobarak L,Zakaria Z,Farid A,Hassany M,Saif S,Mostafa M,Saad OK,Yosry A

更新日期：2018-05-01 00:00:00

abstract：:We performed a comprehensive analysis of innate and adaptive immune responses in dual-virus infected pigs to understand whether a pre-existing immunomodulatory respiratory viral infection affects the overall immunity to a subsequent porcine respiratory coronavirus (PRCV) infection in pigs. Pigs were either mock-infect...

journal_title：Viral immunology

authors： Renukaradhya GJ,Alekseev K,Jung K,Fang Y,Saif LJ

更新日期：2010-10-01 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...

journal_title：Viral immunology

authors： Alhetheel A,Altalhi H,Albarrag A,Shakoor Z,Mohamed D,El-Hazmi M,Somily A,Barry M,Bakhrebah M,Nassar M

更新日期：2017-11-01 00:00:00

abstract：:Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to mi...

journal_title：Viral immunology

authors： Suvas S,Rouse BT

更新日期：2005-01-01 00:00:00

abstract：:We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...

journal_title：Viral immunology

authors： Peters VB,Mayer LF,Sperber KE

更新日期：1997-01-01 00:00:00

abstract：:The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...

journal_title：Viral immunology

authors： Spits HB,Grijsen ML,Steingrover R,Nanlohy NM,Kootstra N,Borghans JA,van Baarle D,Prins JM,Schellens IM

更新日期：2015-04-01 00:00:00

abstract：:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

journal_title：Viral immunology

authors： Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

更新日期：2005-01-01 00:00:00

abstract：:Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...

journal_title：Viral immunology

authors： Yoon KJ,Wu LL,Zimmerman JJ,Hill HT,Platt KB

更新日期：1996-01-01 00:00:00

abstract：:C57BL/6 mice can generate a type-specific and class IH-2Kb-restricted CTL response against histocompatible AKR/Gross murine leukemia virus (MuLV) cell surface antigen positive (GCSA+) tumor cells. These anti-AKR/Gross MuLV CTL are also known to lyse SC.Kb/623 target cells expressing the molecular MuLV clone AKR623 (de...

journal_title：Viral immunology

authors： White HD,Roeder DA,Lam T,Green WR

更新日期：1994-01-01 00:00:00

abstract：:Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclon...

journal_title：Viral immunology

authors： Louisirirotchanakul S,Kanoksinsombat C,Theamboonlert A,Puthavatana P,Wasi C,Poovorawan Y

更新日期：2004-01-01 00:00:00

abstract：:BALB/c mice, preimmunized with a protective dose of native herpes simplex virus type 1 glycoprotein D (ngD1) vaccine, were depleted of selected immunocyte populations in vivo using monoclonal antibodies directed at Thy1+, L3T4+, or Lyt2+ cells. Following immunization and depletion, animals were inoculated with varied ...

journal_title：Viral immunology

authors： Mishkin EM,Blasiak M,Giorgio D,Ishizaka ST

更新日期：1992-07-01 00:00:00

abstract：:In cattle, cells with functional characteristics similar to those of natural killer (NK) cells are difficult to detect. However, lymphokine-activated killer (LAK) cells can be detected readily after in vitro activation of peripheral blood mononuclear leukocytes (PBML) with interleukin-2 (IL-2). In the present study, w...

journal_title：Viral immunology

authors： Campos M,Ohmann HB,Rapin N,Babiuk LA

更新日期：1991-01-01 00:00:00

abstract：:This study is an improvement on the antibody binding test, known as ABT method, to develop a simple and fast method in comparison with NIH for determination of rabies vaccine potency. In the current study, several commercial human and veterinary vaccines were tested using both modified ABT and NIH methods. The ED50 wa...

journal_title：Viral immunology

authors： Asgary V,Mojtabavi N,Janani A,Mousavi T,Hadjati J,Khosravy MS,Ahangari Cohan R

更新日期：2017-04-01 00:00:00

abstract：:Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immuni...

journal_title：Viral immunology

authors： Hofstetter AR,Evavold BD,Lukacher AE

更新日期：2013-02-01 00:00:00

abstract：:Baculovirus is an efficient system for the gene expression that can be used for gene transfer to both insect and different vertebrate hosts. The nucleocapsid gene (N) of the infectious bronchitis virus was cloned in a baculovirus expression system for insect cell expression. Dual expression vectors containing IBV N an...

journal_title：Viral immunology

authors： Abdel-Moneim AS,Giesow K,Keil GM

更新日期：2014-03-01 00:00:00

abstract：:A molecular form of soluble suppressor factor was identified in serum-free supernatant fluid of cultured peripheral blood mononuclear cells (PBMC) from patients with severe forms of papillomavirus infections (epidermodysplasia verruciformis and large treatment-resistant condyloma acuminatum). The papillomavirus-induce...

journal_title：Viral immunology

authors： Chopra V,Chopra AK,Tyring S

更新日期：1991-01-01 00:00:00

abstract：:The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...

journal_title：Viral immunology

authors： Zuffi E,Manaresi E,Gallinella G,Gentilomi GA,Venturoli S,Zerbini M,Musiani M

更新日期：2001-01-01 00:00:00

abstract：:The effects of cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) on the cellular metabolic activity and activation status of bovine peripheral blood mononuclear cells (PBMC) were investigated. Cellular DNA and protein synthesis was determined by [3H]thymidine and [3H]valine incorporation, res...

journal_title：Viral immunology

authors： Hou L,Wilkerson M,Kapil S,Mosier D,Shuman W,Reddy JR,Loughin T,Minocha HC

更新日期：1998-01-01 00:00:00

abstract：:Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC fu...

journal_title：Viral immunology

authors： Johansson SE,Rollman E,Chung AW,Center RJ,Hejdeman B,Stratov I,Hinkula J,Wahren B,Kärre K,Kent SJ,Berg L

更新日期：2011-10-01 00:00:00

abstract：:Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...

journal_title：Viral immunology

authors： Manickan E,Yu Z,Rouse RJ,Wire WS,Rouse BT

更新日期：1995-01-01 00:00:00

abstract：:Pretreatment of mice iv with syngeneic spleen cells modified with soluble HSV envelope antigens induced an anti-HSV antibody hyporesponsiveness following challenge with infectious virus. The epitope density on the HSV-modified spleen cells was quantitated using a photon-counting spectrofluorimeter so that observed imm...

journal_title：Viral immunology

authors： Wilson LA,Thompson JJ,Ohkawa S,Scott DW

更新日期：1992-07-01 00:00:00

abstract：:Highly active anti-retroviral therapy (HAART) restores CD4(+) T-cell numbers in the periphery; however, its efficacy in restoring functional immunity is not fully elucidated. Here we evaluated longitudinal changes in the expression of several key markers of T-cell activation, namely CD40 ligand (CD154), OX40 (CD134), ...

journal_title：Viral immunology

authors： Nyakeriga AM,Ying J,Shire NJ,Fichtenbaum CJ,Chougnet CA

更新日期：2011-08-01 00:00:00

abstract：:The objective of this study was to investigate the immune responses elicited by either a modified-live (MLV) or a killed virus (KV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Specifically, we investigated the effects of multiple vaccinations on antigen-specific cellular and antibody responses...

journal_title：Viral immunology

authors： Bassaganya-Riera J,Thacker BJ,Yu S,Strait E,Wannemuehler MJ,Thacker EL

更新日期：2004-01-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) is a deadly and highly infectious disease caused by SARS Coronavirus (SARS-CoV). Inactivated SARS-CoV has been explored as a vaccine against SARS-CoV; however, current knowledge of inactivated SARS-CoV vaccine is quite limited. We attempted to investigate the effects of differe...

journal_title：Viral immunology

authors： Gai W,Zou W,Lei L,Luo J,Tu H,Zhang Y,Wang K,Tien P,Yan H

更新日期：2008-03-01 00:00:00

abstract：:CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...

journal_title：Viral immunology

authors： Srikiatkhachorn A,Chintapalli J,Liu J,Jamaluddin M,Harrod KS,Whitsett JA,Enelow RI,Ramana CV

更新日期：2010-12-01 00:00:00

abstract：:Mannan-binding lectin (MBL) is a collectin that mediates activation of the complement system and is of importance for host defenses. In humans low concentrations of MBL in serum have been associated with susceptibility to several viral diseases. To understand the function of MBL in relation to infectious viral disease...

journal_title：Viral immunology

authors： Juul-Madsen HR,Norup LR,Handberg KJ,Jørgensen PH

更新日期：2007-12-01 00:00:00

abstract：:Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections...

journal_title：Viral immunology

authors： Smith AM,Huber VC

更新日期：2018-03-01 00:00:00