Abstract：
:Abstract Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate the virological and immunological consequences of MDV infection for the respiratory tract, chickens were infected by intratracheal administration of infective dander. Differences between susceptible and resistant chickens were immediately apparent, with delayed viral replication and earlier onset of interferon (IFN)-gamma production in the latter. CD4(+) and CD8(+) T cells surrounded infected cells in the lung. Although viral replication was evident in macrophages, pulmonary B cells were the main target cell type in susceptible chickens following intratracheal infection with MDV. In accordance, depletion of B cells curtailed viremia and substantially affected pathogenesis in susceptible chickens. Together the data described here demonstrate the role of pulmonary B cells as the primary and predominant target cells and their importance for MDV pathogenesis.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Baaten BJ,Staines KA,Smith LP,Skinner H,Davison TF,Butter Cdoi
10.1089/vim.2009.0047subject
Has Abstractpub_date
2009-12-01 00:00:00pages
431-44issue
6eissn
0882-8245issn
1557-8976journal_volume
22pub_type
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