Characterization of "modified-self"-induced specific antibody hyporesponsiveness to herpes simplex virus.

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 5 (GP5) is the most abundant envelope glycoprotein and a key target for neutralizing antibodies. Previous studies have demonstrated that the native GP5 glycoprotein is poorly immunogenic and not able to induce robust protective responses, probabl...

journal_title：Viral immunology

authors： Wu F,Peng K,Tian J,Xu X,Zhou E,Chen H

更新日期：2014-09-01 00:00:00

abstract：:Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the ...

journal_title：Viral immunology

authors： Witsø E,Cinek O,Tapia G,Rasmussen T,Stene LC,Rønningen KS

更新日期：2012-06-01 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...

journal_title：Viral immunology

authors： Alhetheel A,Altalhi H,Albarrag A,Shakoor Z,Mohamed D,El-Hazmi M,Somily A,Barry M,Bakhrebah M,Nassar M

更新日期：2017-11-01 00:00:00

abstract：:Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...

journal_title：Viral immunology

authors： Askari A,Nosratabadi R,Khaleghinia M,Zainodini N,Kennedy D,Shabani Z,Kazemi Arababadi M

更新日期：2016-11-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...

journal_title：Viral immunology

authors： Peretz Y,Marra O,Thomas R,Legault D,Côté P,Boulassel MR,Rouleau D,Routy JP,Sékaly RP,Tsoukas CM,Tremblay C,Bernard NF

更新日期：2011-06-01 00:00:00

abstract：:Dengue virus (DENV) is an arthropod-borne virus, which belongs to the Flaviviridae family, and completes its life cycle in two hosts: humans and mosquitoes. For DENV maturation, the surface pre-membrane (prM) protein is cleaved to form a mature membrane protein (M) by furin, which is a cellular enzyme subsequently rel...

journal_title：Viral immunology

authors： Raheel U,Jamal M,Zaidi NU

更新日期：2015-09-01 00:00:00

abstract：:To study IgG-specific subclasses of hepatitis B virus (HBV) surface antigen (anti-HBs), in different populations in Taiwan, a comparison was made between 104 chronic carriers (60 male and 44 female) and 439 recovered individuals (247 male and 192 female). Biochemical analyses of aspartate aminotransferase (AST) and al...

journal_title：Viral immunology

authors： Tsai TH,Huang CF,Wei JC,Ho MS,Wang L,Tsai WY,Lin CC,Xu FL,Yang CC

更新日期：2006-07-01 00:00:00

abstract：:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...

journal_title：Viral immunology

authors： Komatsu T,Barna M,Reiss CS

更新日期：1997-01-01 00:00:00

abstract：:Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections...

journal_title：Viral immunology

authors： Smith AM,Huber VC

更新日期：2018-03-01 00:00:00

abstract：:Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...

journal_title：Viral immunology

authors： Yoon KJ,Wu LL,Zimmerman JJ,Hill HT,Platt KB

更新日期：1996-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) signifies an important health issue as it is a globally prevalent pathogen and poses a great threat to human health. Direct antiviral therapy became a landmark in treatment against chronic HCV infection as they have proven to increase sustained virological response (SVR) rate, provide shortened...

journal_title：Viral immunology

authors： Aziz H,Aziz M,Gill ML

更新日期：2018-04-01 00:00:00

abstract：:The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns, resulting in the induction of innate immune responses. Viral RNA in...

journal_title：Viral immunology

authors： Okamoto M,Tsukamoto H,Kouwaki T,Seya T,Oshiumi H

更新日期：2017-07-01 00:00:00

abstract：:Patients with hepatitis B virus (HBV) infection may develop severe chronic liver disease. Carriers of HBV have an increased risk of developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Worldwide an estimated 350 million people are infected with HBV, and 15-40% will develop serious sequelae in th...

journal_title：Viral immunology

authors： Filho RM,Carmo RF,Catsman C,Souza C,Silva A,Moura P,Tenorio AL,Vasconcelos LR,Cavalcanti Mdo S,Pereira LM

更新日期：2010-08-01 00:00:00

abstract：:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

journal_title：Viral immunology

authors： Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

更新日期：2005-01-01 00:00:00

abstract：:Cholangiocarcinoma is a malignancy of the biliary duct system. Presently, these malignant biliary tract diseases are common among the people in Southeast Asia, with the world's highest prevalence in northeastern Thailand and Laos. This carcinoma tends to grow slowly and to infiltrate the walls of the ducts, dissecting...

journal_title：Viral immunology

authors： Pinyosophon A,Wiwanitkit V

更新日期：2002-01-01 00:00:00

abstract：:This study is an improvement on the antibody binding test, known as ABT method, to develop a simple and fast method in comparison with NIH for determination of rabies vaccine potency. In the current study, several commercial human and veterinary vaccines were tested using both modified ABT and NIH methods. The ED50 wa...

journal_title：Viral immunology

authors： Asgary V,Mojtabavi N,Janani A,Mousavi T,Hadjati J,Khosravy MS,Ahangari Cohan R

更新日期：2017-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in immunocompromised hosts, many of whom undergo significant periods of lymphopenia. However, the impact of lymphopenia and subsequent immune reconstitution on T cell responses and pulmonary pathology are poorly understood. Using a model of primar...

journal_title：Viral immunology

authors： Shah PD,Zhong Q,Lendermon EA,Pipeling MR,McDyer JF

更新日期：2015-06-01 00:00:00

abstract：:Mannan-binding lectin (MBL) is a collectin that mediates activation of the complement system and is of importance for host defenses. In humans low concentrations of MBL in serum have been associated with susceptibility to several viral diseases. To understand the function of MBL in relation to infectious viral disease...

journal_title：Viral immunology

authors： Juul-Madsen HR,Norup LR,Handberg KJ,Jørgensen PH

更新日期：2007-12-01 00:00:00

abstract：:Most strategies for reducing global measles morbidity and mortality and eliminating measles are based on the ability to enhance immune responses to measles virus. Challenges to measles elimination and eradication are based in part on the need to sustain high levels of population immunity to interrupt transmission of m...

journal_title：Viral immunology

authors： Moss WJ,Polack FP

更新日期：2001-01-01 00:00:00

abstract：:To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...

journal_title：Viral immunology

authors： Papp Z,Babiuk LA,Baca-Estrada ME

更新日期：1998-01-01 00:00:00

abstract：:We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...

journal_title：Viral immunology

authors： Viera-Segura O,Panduro A,Trujillo-Ochoa JL,Copado-Villagrana E,Torres-Valadez R,Sepulveda-Villegas M,Roman S,Fierro NA

更新日期：2020-11-01 00:00:00

abstract：:The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...

journal_title：Viral immunology

authors： Spits HB,Grijsen ML,Steingrover R,Nanlohy NM,Kootstra N,Borghans JA,van Baarle D,Prins JM,Schellens IM

更新日期：2015-04-01 00:00:00

abstract：:A massive vaccination in Argentina was implemented recently. The antigenic dominants of VP7 in G9 and G1 rotavirus strains, circulating in La Rioja, Argentina with strain vaccines were compared. From 2000 to 2010 in several attention centers of La Rioja, at northwestern Argentina, 418 stool samples from children young...

journal_title：Viral immunology

authors： Cuffia VI,Díaz Ariza Mdel C,Silvera A,Sabini LI,Cordoba PA

更新日期：2016-07-01 00:00:00

abstract：:Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...

journal_title：Viral immunology

authors： Varich NL,Sadykova GK,Prilipov AG,Kochergin-Nikitsky KS,Kushch AA,Masalova OV,Klimova RR,Gitelman AK,Kaverin NV

更新日期：2011-04-01 00:00:00

abstract：:Current treatments for hepatitis C infection have limited efficacy, and there is no vaccine available. The goal of this study was to compare the immune response to several immunization combinations against hepatitis C virus (HCV). Six groups of mice were immunized at weeks 0, 4, and 8 with different combinations of a ...

journal_title：Viral immunology

authors： Ghorbani M,Nass T,Azizi A,Soare C,Aucoin S,Giulivi A,Anderson DE,Diaz-Mitoma F

更新日期：2005-01-01 00:00:00

abstract：:Baculovirus is an efficient system for the gene expression that can be used for gene transfer to both insect and different vertebrate hosts. The nucleocapsid gene (N) of the infectious bronchitis virus was cloned in a baculovirus expression system for insect cell expression. Dual expression vectors containing IBV N an...

journal_title：Viral immunology

authors： Abdel-Moneim AS,Giesow K,Keil GM

更新日期：2014-03-01 00:00:00

abstract：:Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN...

journal_title：Viral immunology

authors： Rodriguez JJ,Horvath CM

更新日期：2004-01-01 00:00:00

abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

journal_title：Viral immunology

authors： Phillips TR,Schultz RD

更新日期：1987-01-01 00:00:00

abstract：:Essen regimen, the Thai Red Cross two-site ID regimen, Zagreb schedule, and the eight-site ID regimen are the standard rabies vaccines recommended by the World Health Organization (WHO). In this study, a liposomal rabies vaccine (LipoRV) was developed, which was found to facilitate the production of rabies virus neutr...

journal_title：Viral immunology

authors： Miao L,Yang Y,Yan M,Li Y,Zhao J,Guo J,Zheng D

更新日期：2017-12-01 00:00:00

abstract：:To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...

journal_title：Viral immunology

authors： Kumar SR,Biswas M,Elankumaran S

更新日期：2014-04-01 00:00:00