Abstract:
:Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically similar to the human herpesviruses, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and cytomegalovirus, had enhanced resistance to subsequent bacterial infection, suggesting protective as well as deleterious effects of latency. Here we confirm that latent gammaHV68 infection confers protection against subsequent infection with Listeria monocytogenes. However, the effect is transient, lasting only a few months.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Yager EJ,Szaba FM,Kummer LW,Lanzer KG,Burkum CE,Smiley ST,Blackman MAdoi
10.1089/vim.2008.0086subject
Has Abstractpub_date
2009-02-01 00:00:00pages
67-72issue
1eissn
0882-8245issn
1557-8976pii
10.1089/vim.2008.0086journal_volume
22pub_type
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