Mutation of the "a" determinant of HBsAg with discordant HBsAg diagnostic kits.

abstract：:Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...

journal_title：Viral immunology

authors： Dinca L,Neuwirth S,Schulman J,Bona C

更新日期：1993-04-01 00:00:00

abstract：:We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

journal_title：Viral immunology

authors： Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

更新日期：2012-06-01 00:00:00

abstract：:Naïve CD8(+) T cells differentiate into effectors secreting various cytokines that modulate immune functions. A striking finding for most HIV-1-infected patients is that they accumulate CD8(+) T cells belonging to early and intermediate differentiated elements. Structural HIV-1 proteins, and among these the matrix pro...

journal_title：Viral immunology

authors： Avolio M,Caracciolo S,Tosti G,Vollero L,Fiorentini S,Caruso A

更新日期：2008-06-01 00:00:00

abstract：:The host genetic compound plays a vital role in determining clinical outcomes of hepatitis B virus (HBV) infection. The tumor necrosis factor receptor-associated factor family member-associated nuclear factor-κB (NF-κB) activator (TANK) takes part in the tumor necrosis factor-α (TNF-α)-mediated NF-κB signaling pathway...

journal_title：Viral immunology

authors： Song QL,He XX,Yang H,Li J,Chen M,Wang MY,Liu Q,Yu JL,Yao JJ,Liu LF,Sun SZ,Lin JS

更新日期：2012-02-01 00:00:00

abstract：:Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...

journal_title：Viral immunology

authors： Park EH,Song BM,Yum J,Kim JA,Oh SK,Kim HS,Cho GJ,Seo SH

更新日期：2014-11-01 00:00:00

abstract：:In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centril...

journal_title：Viral immunology

authors： Wong M,Woolford L,Hasan NH,Hemmatzadeh F

更新日期：2017-05-01 00:00:00

abstract：:Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...

journal_title：Viral immunology

authors： Liu Y,Zhang Z,Zhao X,Yu R,Zhang X,Wu S,Liu J,Chi X,Song X,Fu L,Yu Y,Hou L,Chen W

更新日期：2014-08-01 00:00:00

abstract：:To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...

journal_title：Viral immunology

authors： Papp Z,Babiuk LA,Baca-Estrada ME

更新日期：1998-01-01 00:00:00

abstract：:Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...

journal_title：Viral immunology

authors： Gruber A,Chalmers AS,Rasmussen RA,Ong H,Popov S,Andersen J,Hu SL,Ruprecht RM

更新日期：2007-04-01 00:00:00

abstract：:Abstract IL-17 producing CD4 T cells have recently been shown to play an important role in mucosal immunity in HIV infection. But its role in peripheral immunity and the molecular mechanism underlying its regulation during HIV-1 infection are ill defined. In this study, we report a significant negative correlation b...

journal_title：Viral immunology

authors： Singh A,Vajpayee M,Ali SA,Chauhan NK

更新日期：2013-02-01 00:00:00

abstract：:This study was aimed at investigating the genes that control host responses to Marek's disease virus (MDV). Spleen tissues from infected and age-matched uninfected control chickens were examined 4, 7, 14, and 21 d postinfection for gene expression differences, using both microarray and quantitative real-time polymeras...

journal_title：Viral immunology

authors： Sarson AJ,Abdul-Careem MF,Zhou H,Sharif S

更新日期：2006-01-01 00:00:00

abstract：:CD3+CD8+CD11+ cells were present in the peripheral blood of patients infected with asymptomatic human immunodeficiency virus (HIV) in higher percentage (10-20%) than in normal individuals (3-5%) in this study. These cells, through the release of soluble factors, significantly suppressed the effector phase of anti-HIV ...

journal_title：Viral immunology

authors： Kundu SK,Merigan TC

更新日期：1992-04-01 00:00:00

abstract：:A paresis isolate of equid herpesvirus 1 (EHV1, Ab4/8) and a plaque-purified virus derived from it (EHV1, Ab4/13), induced long-term suppression of both mitogenic and antigen-specific lymphocyte proliferations in adult outbred ponies. Peripheral blood mononuclear cells (PBMC) taken from a pony after EHV1 infection sup...

journal_title：Viral immunology

authors： Hannant D,O'Neill T,Ostlund EN,Kydd JH,Hopkin PJ,Mumford JA

更新日期：1999-01-01 00:00:00

abstract：:We examined whether immunization with a single peptide induces cytotoxic T lymphocytes (CTLs) of heterogeneous specificities in vivo. Immunization of BALB/c mice with the peptide H2:529-537, which corresponded to amino acid residues 529-537 on the HA2 subunit transmembrane region of influenza A/Jap virus (H2N2) and po...

journal_title：Viral immunology

authors： Masaki H,Tamura M,Kurane I

更新日期：2000-01-01 00:00:00

abstract：:Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...

journal_title：Viral immunology

authors： Chua BY,Sekiya T,Jackson DC

更新日期：2018-03-01 00:00:00

abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

journal_title：Viral immunology

authors： Phillips TR,Schultz RD

更新日期：1987-01-01 00:00:00

abstract：:Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...

journal_title：Viral immunology

authors： Santosuosso M,McCormick S,Xing Z

更新日期：2005-01-01 00:00:00

abstract：:Avian infectious bronchitis virus (IBV), which is prevalent in many countries causing severe economic loss to the poultry industry, causes infectious bronchitis (IB) in birds. Recombinant single-chain variable fragments (scFvs) have been proven to effectively inhibit many viruses, both in vitro and in vivo, and they c...

journal_title：Viral immunology

authors： Lin Y,Li B,Ye J,Wang M,Wang J,Zhang Y,Zhu J

更新日期：2015-09-01 00:00:00

abstract：:Expression of the high-affinity interleukin 2 receptor alpha chain (CD25) was used to monitor antigen-specific activation of T lymphocyte subsets (CD4+, CD8+, and gammadelta T cells) from cattle immunized with modified live bovine herpesvirus-1 (BHV-1). Calves seronegative for BHV-1 were either vaccinated with one dos...

journal_title：Viral immunology

authors： Endsley JJ,Quade MJ,Terhaar B,Roth JA

更新日期：2002-01-01 00:00:00

abstract：:Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC fu...

journal_title：Viral immunology

authors： Johansson SE,Rollman E,Chung AW,Center RJ,Hejdeman B,Stratov I,Hinkula J,Wahren B,Kärre K,Kent SJ,Berg L

更新日期：2011-10-01 00:00:00

abstract：:Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...

journal_title：Viral immunology

authors： Creery D,Weiss W,Graziani-Bowering G,Kumar R,Aziz Z,Angel JB,Kumar A

更新日期：2006-07-01 00:00:00

abstract：:Today, hepatitis C virus (HCV) infection is considered as one of the most significant international health concerns. Although novel therapeutic regimens against the infection have shown satisfactory results, no approved vaccine exists yet. This study aimed to evaluate the immunogenicity of a DNA vaccine candidate for ...

journal_title：Viral immunology

authors： Behzadi MA,Alborzi A,Kalani M,Pouladfar G,Dianatpour M,Ziyaeyan M

更新日期：2016-04-01 00:00:00

abstract：:California (CAL) serogroup Bunyaviruses are significant agents of arboviral encephalitis in humans. They are maintained and transmitted in nature by mosquitoes to preferred vertebrate amplifying hosts. The G2 envelope glycoprotein of La Crosse virus (LAC) was proposed by Ludwig et al. to be a determinant for virus att...

journal_title：Viral immunology

authors： Cheng LL,Schultz KT,Yuill TM,Israel BA

更新日期：2000-01-01 00:00:00

abstract：:Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...

journal_title：Viral immunology

authors： Varich NL,Sadykova GK,Prilipov AG,Kochergin-Nikitsky KS,Kushch AA,Masalova OV,Klimova RR,Gitelman AK,Kaverin NV

更新日期：2011-04-01 00:00:00

abstract：:There is limited information on the direct role of the neutralizing antibody responses against hepatitis C virus (HCV) infection or methodologies to study them. Previously we have demonstrated that interleukin-10 (IL-10) administered to chronic hepatitis patients led to a decrease in disease activity, but an increase ...

journal_title：Viral immunology

authors： Eksioglu EA,Bess J,Jones G,Dettloff J,Dangmeon P,Dong HJ,Zhu H,Firpi R,Xu Y,Nelson DR,Liu C

更新日期：2010-08-01 00:00:00

abstract：:Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immuni...

journal_title：Viral immunology

authors： Hofstetter AR,Evavold BD,Lukacher AE

更新日期：2013-02-01 00:00:00

abstract：:Infection of mice with murine gammaherpesvirus-68 (γHV-68) serves as a model to understand the pathogenesis of persistent viral infections, including the potential for co-infections to modulate viral latency. We have previously found that infection of neonates (8-day-old mice) with γHV-68 resulted in a high level of p...

journal_title：Viral immunology

authors： Ptaschinski C,Wilmore J,Fiore N,Rochford R

更新日期：2010-12-01 00:00:00

abstract：:Findings coming from autopsies and serum of SARS patients suggest an important immune-inflammatory implication in the evolution to respiratory distress. Conditions such as HIV infection or treatment with immunosuppressors (in cancer or autoimmune diseases) are not among the bad prognosis factors for development of dis...

journal_title：Viral immunology

authors： Bermejo JF,Muñoz-Fernandez MA

更新日期：2004-01-01 00:00:00

abstract：:During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...

journal_title：Viral immunology

authors： Sollazzo M,Glotz D,Castiglia D,Zanetti M

更新日期：1989-01-01 00:00:00

abstract：:Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...

journal_title：Viral immunology

authors： Lundkvist A,Meisel H,Koletzki D,Lankinen H,Cifire F,Geldmacher A,Sibold C,Gött P,Vaheri A,Krüger DH,Ulrich R

更新日期：2002-01-01 00:00:00