Abstract:
:A paresis isolate of equid herpesvirus 1 (EHV1, Ab4/8) and a plaque-purified virus derived from it (EHV1, Ab4/13), induced long-term suppression of both mitogenic and antigen-specific lymphocyte proliferations in adult outbred ponies. Peripheral blood mononuclear cells (PBMC) taken from a pony after EHV1 infection suppressed the in vitro function of normal cells but serum did not. This showed that the observed immune suppression was associated with circulating PBMC and/or their products rather than circulating soluble factors such as antigen or immune complexes. The results suggested that productive infection of lymphocytes by EHV1 was unlikely to result in the observed in vitro effects. Moreover, prostaglandin release from monocytes was not likely to have caused the observed suppression, because lymphocyte responsiveness was not restored in the presence of indomethacin.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Hannant D,O'Neill T,Ostlund EN,Kydd JH,Hopkin PJ,Mumford JAdoi
10.1089/vim.1999.12.313subject
Has Abstractpub_date
1999-01-01 00:00:00pages
313-21issue
4eissn
0882-8245issn
1557-8976journal_volume
12pub_type
杂志文章相关文献
VIRAL IMMUNOLOGY文献大全abstract::Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1996.9.51
更新日期:1996-01-01 00:00:00
abstract::The VP1 represents the major capsid protein of the hamster polyomavirus (HaPV). Here we describe the mapping of epitopes along the VP1 using Escherichia coli-expressed VP1-dihydrofolate reductase (DHFR) fusion proteins and PepScan analysis. By use of DHFR fusion proteins an immunodominant region was localized in the C...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2000.13.533
更新日期:2000-01-01 00:00:00
abstract::Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0095
更新日期:2015-04-01 00:00:00
abstract::Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0146
更新日期:2018-03-01 00:00:00
abstract::During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.1989.2.263
更新日期:1989-01-01 00:00:00
abstract::We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0064
更新日期:2020-11-01 00:00:00
abstract::To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0093
更新日期:2014-04-01 00:00:00
abstract::TransFix(TM) and Cyto-Chex((R)) BCT (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. We evaluated the ability of these blood-stabilizing reagents to preserve HIV-seropositive blood for delayed CD4(+) T-cell quantification utilizing the ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0027
更新日期:2009-10-01 00:00:00
abstract::To study IgG-specific subclasses of hepatitis B virus (HBV) surface antigen (anti-HBs), in different populations in Taiwan, a comparison was made between 104 chronic carriers (60 male and 44 female) and 439 recovered individuals (247 male and 192 female). Biochemical analyses of aspartate aminotransferase (AST) and al...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.277
更新日期:2006-07-01 00:00:00
abstract::Immunization with hepatitis B vaccine is an effective measure for prevention and control of hepatitis B Virus (HBV) infection. Although lots of efforts to improve the effect of hepatitis B vaccine have been made, the function of human beta defensin 2 (hBD2) on hepatitis B vaccine keeps unclear. In this article, we rep...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0052
更新日期:2020-12-28 00:00:00
abstract::Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically s...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0086
更新日期:2009-02-01 00:00:00
abstract::Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.381
更新日期:2005-01-01 00:00:00
abstract::In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infec...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/088282403763635465
更新日期:2003-01-01 00:00:00
abstract::Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.409
更新日期:2006-07-01 00:00:00
abstract::Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0117
更新日期:2011-06-01 00:00:00
abstract::We investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the Second World War, when dengue fever epidemics occurred throughout the Pacific and Southeast Asia. In July 1943 dengue fever reappeared in Hawaii following ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2007.0050
更新日期:2007-12-01 00:00:00
abstract::Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0029
更新日期:2014-11-01 00:00:00
abstract::Bacterial flagellin is a potent adjuvant that enhances adaptive immune responses to a variety of protein antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore we evaluated the humoral res...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0107
更新日期:2010-04-01 00:00:00
abstract::One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the swit...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2019.0149
更新日期:2020-05-01 00:00:00
abstract::Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infecti...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2007.0013
更新日期:2007-07-01 00:00:00
abstract::The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns, resulting in the induction of innate immune responses. Viral RNA in...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2016.0178
更新日期:2017-07-01 00:00:00
abstract::Serum antibodies against the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18 are associated with cervical cancer. The aim of this study was to investigate the presence of local antibodies against HPV in cervicovaginal washings (CWs). In this study antibodies against the native HPV16 and HPV18 E6/E7 proteins...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240152716655
更新日期:2001-01-01 00:00:00
abstract::Today, hepatitis C virus (HCV) infection is considered as one of the most significant international health concerns. Although novel therapeutic regimens against the infection have shown satisfactory results, no approved vaccine exists yet. This study aimed to evaluate the immunogenicity of a DNA vaccine candidate for ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2015.0085
更新日期:2016-04-01 00:00:00
abstract::CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0076
更新日期:2010-12-01 00:00:00
abstract::Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240050144680
更新日期:2000-01-01 00:00:00
abstract::Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0098
更新日期:2018-05-01 00:00:00
abstract::Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly cell-associated alpha herpesvirus, Marek's disease virus (MDV). Clinical signs of MD include depression, crippling, weight loss, and transient paralysis (TP). TP is a disease of the central nervous system that affects MD-susc...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2012.0003
更新日期:2012-08-01 00:00:00
abstract::Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1993.6.75
更新日期:1993-04-01 00:00:00
abstract::Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To ac...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0025
更新日期:2017-07-01 00:00:00
abstract::The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.162
更新日期:2005-01-01 00:00:00