Equid herpesvirus-induced immunosuppression is associated with lymphoid cells and not soluble circulating factors.

Abstract:

:A paresis isolate of equid herpesvirus 1 (EHV1, Ab4/8) and a plaque-purified virus derived from it (EHV1, Ab4/13), induced long-term suppression of both mitogenic and antigen-specific lymphocyte proliferations in adult outbred ponies. Peripheral blood mononuclear cells (PBMC) taken from a pony after EHV1 infection suppressed the in vitro function of normal cells but serum did not. This showed that the observed immune suppression was associated with circulating PBMC and/or their products rather than circulating soluble factors such as antigen or immune complexes. The results suggested that productive infection of lymphocytes by EHV1 was unlikely to result in the observed in vitro effects. Moreover, prostaglandin release from monocytes was not likely to have caused the observed suppression, because lymphocyte responsiveness was not restored in the presence of indomethacin.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Hannant D,O'Neill T,Ostlund EN,Kydd JH,Hopkin PJ,Mumford JA

doi

10.1089/vim.1999.12.313

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

313-21

issue

4

eissn

0882-8245

issn

1557-8976

journal_volume

12

pub_type

杂志文章
  • Antibody-dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs.

    abstract::Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.1996.9.51

    authors: Yoon KJ,Wu LL,Zimmerman JJ,Hill HT,Platt KB

    更新日期:1996-01-01 00:00:00

  • An immunodominant, cross-reactive B-cell epitope region is located at the C-terminal part of the hamster polyomavirus major capsid protein VP1.

    abstract::The VP1 represents the major capsid protein of the hamster polyomavirus (HaPV). Here we describe the mapping of epitopes along the VP1 using Escherichia coli-expressed VP1-dihydrofolate reductase (DHFR) fusion proteins and PepScan analysis. By use of DHFR fusion proteins an immunodominant region was localized in the C...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2000.13.533

    authors: Siray H,Frömmel C,Voronkova T,Hahn S,Arnold W,Schneider-Mergener J,Scherneck S,Ulrich R

    更新日期:2000-01-01 00:00:00

  • Protein disulfide isomerase mediates dengue virus entry in association with lipid rafts.

    abstract::Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2014.0095

    authors: Diwaker D,Mishra KP,Ganju L,Singh SB

    更新日期:2015-04-01 00:00:00

  • Opinion: Making Inactivated and Subunit-Based Vaccines Work.

    abstract::Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2017.0146

    authors: Chua BY,Sekiya T,Jackson DC

    更新日期:2018-03-01 00:00:00

  • Autoantibody idiotypy and neonatal B cell repertoire.

    abstract::During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.1989.2.263

    authors: Sollazzo M,Glotz D,Castiglia D,Zanetti M

    更新日期:1989-01-01 00:00:00

  • Evidence for Increased Inflammatory Cytokine Profile in Hepatitis E Virus-Infected Obese Patients: Implications for Chronic Liver Disease.

    abstract::We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2020.0064

    authors: Viera-Segura O,Panduro A,Trujillo-Ochoa JL,Copado-Villagrana E,Torres-Valadez R,Sepulveda-Villegas M,Roman S,Fierro NA

    更新日期:2020-11-01 00:00:00

  • Pandemic H1N1 influenza A virus induces a potent innate immune response in human chorionic cells.

    abstract::To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2013.0093

    authors: Kumar SR,Biswas M,Elankumaran S

    更新日期:2014-04-01 00:00:00

  • Evaluation of the blood stabilizers TransFix and Cyto-Chex BCT for low-cost CD4 T-cell methodologies.

    abstract::TransFix(TM) and Cyto-Chex((R)) BCT (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. We evaluated the ability of these blood-stabilizing reagents to preserve HIV-seropositive blood for delayed CD4(+) T-cell quantification utilizing the ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2009.0027

    authors: Plate MM,Louzao R,Steele PM,Greengrass V,Morris LM,Lewis J,Barnett D,Warrino D,Hearps AC,Denny T,Crowe SM

    更新日期:2009-10-01 00:00:00

  • Study of IgG subclass profiles of anti-HBs in populations with different HBV infection status.

    abstract::To study IgG-specific subclasses of hepatitis B virus (HBV) surface antigen (anti-HBs), in different populations in Taiwan, a comparison was made between 104 chronic carriers (60 male and 44 female) and 439 recovered individuals (247 male and 192 female). Biochemical analyses of aspartate aminotransferase (AST) and al...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2006.19.277

    authors: Tsai TH,Huang CF,Wei JC,Ho MS,Wang L,Tsai WY,Lin CC,Xu FL,Yang CC

    更新日期:2006-07-01 00:00:00

  • The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice.

    abstract::Immunization with hepatitis B vaccine is an effective measure for prevention and control of hepatitis B Virus (HBV) infection. Although lots of efforts to improve the effect of hepatitis B vaccine have been made, the function of human beta defensin 2 (hBD2) on hepatitis B vaccine keeps unclear. In this article, we rep...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2020.0052

    authors: Wang M,Zeng W,Zhang Z,Zhang W,Su H,Zhang Z,Jiang L,Liu Y,Shi Q

    更新日期:2020-12-28 00:00:00

  • gamma-Herpesvirus-induced protection against bacterial infection is transient.

    abstract::Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically s...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2008.0086

    authors: Yager EJ,Szaba FM,Kummer LW,Lanzer KG,Burkum CE,Smiley ST,Blackman MA

    更新日期:2009-02-01 00:00:00

  • Porcine reproductive and respiratory syndrome (PRRS) virus-specific interferon-gamma(+) T-cell responses after PRRS virus infection or vaccination with an inactivated PRRS vaccine.

    abstract::Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2005.18.381

    authors: Piras F,Bollard S,Laval F,Joisel F,Reynaud G,Charreyre C,Andreoni C,Juillard V

    更新日期:2005-01-01 00:00:00

  • Antibody-dependent enhancement of virus infection and disease.

    abstract::In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infec...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/088282403763635465

    authors: Tirado SM,Yoon KJ

    更新日期:2003-01-01 00:00:00

  • Differential regulation of CXCR4 and CCR5 expression by interleukin (IL)-4 and IL-13 is associated with inhibition of chemotaxis and human immunodeficiency Virus (HIV) type 1 replication but not HIV entry into human monocytes.

    abstract::Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2006.19.409

    authors: Creery D,Weiss W,Graziani-Bowering G,Kumar R,Aziz Z,Angel JB,Kumar A

    更新日期:2006-07-01 00:00:00

  • Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles.

    abstract::Expression of major histocompatibility complex (MHC) class I alleles such as B*57 and B*27 are associated with slow HIV disease progression. HIV-specific immune responses in slow progressors (SP) are characterized by a poly-functional profile. We previously observed within infected subjects that HIV peptide-specific r...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2010.0117

    authors: Peretz Y,Marra O,Thomas R,Legault D,Côté P,Boulassel MR,Rouleau D,Routy JP,Sékaly RP,Tsoukas CM,Tremblay C,Bernard NF

    更新日期:2011-06-01 00:00:00

  • Antibody to dengue 1 detected more than 60 years after infection.

    abstract::We investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the Second World War, when dengue fever epidemics occurred throughout the Pacific and Southeast Asia. In July 1943 dengue fever reappeared in Hawaii following ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2007.0050

    authors: Imrie A,Meeks J,Gurary A,Sukhbaatar M,Truong TT,Cropp CB,Effler P

    更新日期:2007-12-01 00:00:00

  • Protective efficacy of a single dose of baculovirus hemagglutinin-based vaccine in chickens and ducks against homologous and heterologous H5N1 virus infections.

    abstract::Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2014.0029

    authors: Park EH,Song BM,Yum J,Kim JA,Oh SK,Kim HS,Cho GJ,Seo SH

    更新日期:2014-11-01 00:00:00

  • A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice.

    abstract::Bacterial flagellin is a potent adjuvant that enhances adaptive immune responses to a variety of protein antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore we evaluated the humoral res...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2009.0107

    authors: Delaney KN,Phipps JP,Johnson JB,Mizel SB

    更新日期:2010-04-01 00:00:00

  • What Targets Somatic Hypermutation to the Immunoglobulin Loci?

    abstract::One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the swit...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2019.0149

    authors: Heltzel JMH,Gearhart PJ

    更新日期:2020-05-01 00:00:00

  • Environmental toxins as modulators of antiviral immune responses.

    abstract::Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infecti...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2007.0013

    authors: Lawrence BP

    更新日期:2007-07-01 00:00:00

  • Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

    abstract::The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns, resulting in the induction of innate immune responses. Viral RNA in...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2016.0178

    authors: Okamoto M,Tsukamoto H,Kouwaki T,Seya T,Oshiumi H

    更新日期:2017-07-01 00:00:00

  • Antibodies against human papillomavirus type 16 and 18 E6 and E7 proteins in cervicovaginal washings and serum of patients with cervical neoplasia.

    abstract::Serum antibodies against the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18 are associated with cervical cancer. The aim of this study was to investigate the presence of local antibodies against HPV in cervicovaginal washings (CWs). In this study antibodies against the native HPV16 and HPV18 E6/E7 proteins...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/08828240152716655

    authors: Tjiong MY,Zumbach K,Schegget JT,van der Vange N,Out TA,Pawlita M,Struyk L

    更新日期:2001-01-01 00:00:00

  • Immunization with a Recombinant Expression Vector Encoding NS3/NS4A of Hepatitis C Virus Genotype 3a Elicits Cell-Mediated Immune Responses in C57BL/6 Mice.

    abstract::Today, hepatitis C virus (HCV) infection is considered as one of the most significant international health concerns. Although novel therapeutic regimens against the infection have shown satisfactory results, no approved vaccine exists yet. This study aimed to evaluate the immunogenicity of a DNA vaccine candidate for ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2015.0085

    authors: Behzadi MA,Alborzi A,Kalani M,Pouladfar G,Dianatpour M,Ziyaeyan M

    更新日期:2016-04-01 00:00:00

  • Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.

    abstract::CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2010.0076

    authors: Srikiatkhachorn A,Chintapalli J,Liu J,Jamaluddin M,Harrod KS,Whitsett JA,Enelow RI,Ramana CV

    更新日期:2010-12-01 00:00:00

  • Detection of genetic diversity among bovine immunodeficiency virus population by single-strand conformation polymorphism analysis.

    abstract::Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/08828240050144680

    authors: Kalvatchev Z,Walder R,Garzaro D,Barrios M

    更新日期:2000-01-01 00:00:00

  • The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus.

    abstract::Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2017.0098

    authors: Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

    更新日期:2018-05-01 00:00:00

  • Very virulent plus strains of MDV induce an acute form of transient paralysis in both susceptible and resistant chicken lines.

    abstract::Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly cell-associated alpha herpesvirus, Marek's disease virus (MDV). Clinical signs of MD include depression, crippling, weight loss, and transient paralysis (TP). TP is a disease of the central nervous system that affects MD-susc...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2012.0003

    authors: Xu M,Fitzgerald SD,Zhang H,Karcher DM,Heidari M

    更新日期:2012-08-01 00:00:00

  • Induction of antihemagglutinin antibodies by polyclonal antiidiotype antibodies.

    abstract::Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.1993.6.75

    authors: Dinca L,Neuwirth S,Schulman J,Bona C

    更新日期:1993-04-01 00:00:00

  • Adaptive B Cell Responses to Influenza Virus Infection in the Lung.

    abstract::Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To ac...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2017.0025

    authors: Takahashi Y,Onodera T,Adachi Y,Ato M

    更新日期:2017-07-01 00:00:00

  • Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2.

    abstract::The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2005.18.162

    authors: Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

    更新日期:2005-01-01 00:00:00