Abstract:
:To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being more apoptotic. A strong induction of innate signaling molecules, type I interferon and pro-inflammatory cytokine production, were associated with pdm IAV infection of human placental cells, with implications for adverse immediate and late outcomes during pregnancy.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Kumar SR,Biswas M,Elankumaran Sdoi
10.1089/vim.2013.0093subject
Has Abstractpub_date
2014-04-01 00:00:00pages
129-37issue
3eissn
0882-8245issn
1557-8976journal_volume
27pub_type
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