Use of Synthetic Peptides and Multiple Antigen Blot Assay in the Immunodiagnosis of Hepatitis C Virus Infection.

abstract：:As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...

journal_title：Viral immunology

authors： He Y,Katze MG

更新日期：2002-01-01 00:00:00

abstract：:Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...

journal_title：Viral immunology

authors： Gruber A,Chalmers AS,Rasmussen RA,Ong H,Popov S,Andersen J,Hu SL,Ruprecht RM

更新日期：2007-04-01 00:00:00

abstract：:Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...

journal_title：Viral immunology

authors： Kalvatchev Z,Walder R,Garzaro D,Barrios M

更新日期：2000-01-01 00:00:00

abstract：:In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centril...

journal_title：Viral immunology

authors： Wong M,Woolford L,Hasan NH,Hemmatzadeh F

更新日期：2017-05-01 00:00:00

abstract：:A massive vaccination in Argentina was implemented recently. The antigenic dominants of VP7 in G9 and G1 rotavirus strains, circulating in La Rioja, Argentina with strain vaccines were compared. From 2000 to 2010 in several attention centers of La Rioja, at northwestern Argentina, 418 stool samples from children young...

journal_title：Viral immunology

authors： Cuffia VI,Díaz Ariza Mdel C,Silvera A,Sabini LI,Cordoba PA

更新日期：2016-07-01 00:00:00

abstract：:To study IgG-specific subclasses of hepatitis B virus (HBV) surface antigen (anti-HBs), in different populations in Taiwan, a comparison was made between 104 chronic carriers (60 male and 44 female) and 439 recovered individuals (247 male and 192 female). Biochemical analyses of aspartate aminotransferase (AST) and al...

journal_title：Viral immunology

authors： Tsai TH,Huang CF,Wei JC,Ho MS,Wang L,Tsai WY,Lin CC,Xu FL,Yang CC

更新日期：2006-07-01 00:00:00

abstract：:HIV infection is characterized by a high degree of immune activation. It has an impact on CD4 cell count and populations' distribution and function. T regulatory cells (Tregs) were found to play a controversial role in the course of infection because of their beneficial effect on the degree of immune activation and un...

journal_title：Viral immunology

authors： Terzieva VI,Popova DN,Elenkov II

更新日期：2017-04-01 00:00:00

abstract：:The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA an...

journal_title：Viral immunology

authors： Herrmann M,Baur A,Nebel-Schickel H,Vornhagen R,Jahn G,Krapf FE,Kalden JR

更新日期：1992-10-01 00:00:00

abstract：:Cervical intraepithelial neoplasias (CINs) are a major public health issue. The prevalence of CINs is higher in women with the human immunodeficiency virus (HIV). The objective of this study was to determine whether there are differences in the immune responses in the cervical stroma of HIV-infected and -uninfected wo...

journal_title：Viral immunology

authors： Guimarães MV,Michelin MA,Lucena AA,Lodi CT,Lima MI,Murta EF,Melo VH

更新日期：2014-09-01 00:00:00

abstract：:We have previously demonstrated the formation and release of influenza virus-like particles (VLPs) from the surface of Sf9 cells infected with either a quadruple baculovirus recombinant that simultaneously expresses the influenza structural proteins hemagglutinin (HA), neuraminidase (NA), matrix 1 (M1) and M2, or a co...

journal_title：Viral immunology

authors： Galarza JM,Latham T,Cupo A

更新日期：2005-01-01 00:00:00

abstract：:Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...

journal_title：Viral immunology

authors： Santosuosso M,McCormick S,Xing Z

更新日期：2005-01-01 00:00:00

abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

journal_title：Viral immunology

authors： Phillips TR,Schultz RD

更新日期：1987-01-01 00:00:00

abstract：:Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...

journal_title：Viral immunology

authors： Piras F,Bollard S,Laval F,Joisel F,Reynaud G,Charreyre C,Andreoni C,Juillard V

更新日期：2005-01-01 00:00:00

abstract：:Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...

journal_title：Viral immunology

authors： Sarkar AK,Tortolero-Luna G,Nehete PN,Arlinghaus RB,Mitchell MF,Sastry KJ

更新日期：1995-01-01 00:00:00

abstract：:There is limited information on the direct role of the neutralizing antibody responses against hepatitis C virus (HCV) infection or methodologies to study them. Previously we have demonstrated that interleukin-10 (IL-10) administered to chronic hepatitis patients led to a decrease in disease activity, but an increase ...

journal_title：Viral immunology

authors： Eksioglu EA,Bess J,Jones G,Dettloff J,Dangmeon P,Dong HJ,Zhu H,Firpi R,Xu Y,Nelson DR,Liu C

更新日期：2010-08-01 00:00:00

abstract：:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

journal_title：Viral immunology

authors： Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

更新日期：2005-01-01 00:00:00

abstract：:Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...

journal_title：Viral immunology

authors： Liang SH,Rieber P,Prewett M,Riethmüller G,Pletcher C,Hoxie J,Koprowski H,Herlyn D

更新日期：1991-07-01 00:00:00

abstract：:Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...

journal_title：Viral immunology

authors： Chakraborty J,Clark S,Okonta H,Duggan J

更新日期：2003-01-01 00:00:00

abstract：:Studies of immune function in human immunodeficiency virus (HIV)-infected children are important, because functional abnormalities can precede CD4+ T-cell loss and are associated with the development of opportunistic and bacterial infections. We sought to correlate clinical parameters and immunological function with H...

journal_title：Viral immunology

authors： Peters VB,Mayer L,Sperber KE

更新日期：1999-01-01 00:00:00

abstract：:Abstract IL-17 producing CD4 T cells have recently been shown to play an important role in mucosal immunity in HIV infection. But its role in peripheral immunity and the molecular mechanism underlying its regulation during HIV-1 infection are ill defined. In this study, we report a significant negative correlation b...

journal_title：Viral immunology

authors： Singh A,Vajpayee M,Ali SA,Chauhan NK

更新日期：2013-02-01 00:00:00

abstract：:The purpose of the study was to evaluate pathologically the reproductive system of nonvaccinated and porcine reproductive and respiratory syndrome virus (PRRSV)-vaccinated sows/gilts, as well as the assessment of vaccination impact on their endometrium/myometrium and ovaries. In a farrow-to-finish farm, all sows and g...

journal_title：Viral immunology

authors： Papatsiros V,Psalla D,Papaioannou D,Tassis P,Tzika E,Papaioannou N

更新日期：2015-05-01 00:00:00

abstract：:The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...

journal_title：Viral immunology

authors： Spits HB,Grijsen ML,Steingrover R,Nanlohy NM,Kootstra N,Borghans JA,van Baarle D,Prins JM,Schellens IM

更新日期：2015-04-01 00:00:00

abstract：:Most strategies for reducing global measles morbidity and mortality and eliminating measles are based on the ability to enhance immune responses to measles virus. Challenges to measles elimination and eradication are based in part on the need to sustain high levels of population immunity to interrupt transmission of m...

journal_title：Viral immunology

authors： Moss WJ,Polack FP

更新日期：2001-01-01 00:00:00

abstract：:Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...

journal_title：Viral immunology

authors： Rehman SU,Rauf M,Abbas Z,Hamed MH,Qadri I

更新日期：2016-12-01 00:00:00

abstract：:Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...

journal_title：Viral immunology

authors： Park EH,Song BM,Yum J,Kim JA,Oh SK,Kim HS,Cho GJ,Seo SH

更新日期：2014-11-01 00:00:00

abstract：:The objective of this study was to develop a new antigen delivery system using an alphavirus replicon particle (RP) to induce humoral antibody responses against bovine viral diarrhea virus (BVDV) recombinant antigen produced from envelope glycoprotein E2. An alphavirus RP expressing the E2 glycoprotein of BVDV was use...

journal_title：Viral immunology

authors： Hossain MM,Rowland RR

更新日期：2018-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in immunocompromised hosts, many of whom undergo significant periods of lymphopenia. However, the impact of lymphopenia and subsequent immune reconstitution on T cell responses and pulmonary pathology are poorly understood. Using a model of primar...

journal_title：Viral immunology

authors： Shah PD,Zhong Q,Lendermon EA,Pipeling MR,McDyer JF

更新日期：2015-06-01 00:00:00

abstract：:Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy and scrapie in sheep and goats. Transmissible spongiform encephalopathies are thought by some to result from changes in the conformation of a membrane glyco...

journal_title：Viral immunology

authors： Daude N

更新日期：2004-01-01 00:00:00

abstract：:Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

journal_title：Viral immunology

authors： Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

更新日期：2018-05-01 00:00:00

abstract：:Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infecti...

journal_title：Viral immunology

authors： Lawrence BP

更新日期：2007-07-01 00:00:00