Abstract：
:Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-amplified gp70 cDNA genes from L5178Y cells. One of the resulting clones was used as a probe in Southern and Northern analysis of parental and xenogenized cells. The results indicated that xenogenization of tumor cells is associated with changes in retroviral env sequences detectable at the genomic level.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti Pdoi
10.1089/vim.1994.7.155subject
Has Abstractpub_date
1994-01-01 00:00:00pages
155-67issue
4eissn
0882-8245issn
1557-8976journal_volume
7pub_type
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