A Molecular Approach Designed to Limit the Replication of Mature DENV2 in Host Cells.

abstract：:Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...

journal_title：Viral immunology

authors： Varich NL,Sadykova GK,Prilipov AG,Kochergin-Nikitsky KS,Kushch AA,Masalova OV,Klimova RR,Gitelman AK,Kaverin NV

更新日期：2011-04-01 00:00:00

abstract：:Cholangiocarcinoma is a malignancy of the biliary duct system. Presently, these malignant biliary tract diseases are common among the people in Southeast Asia, with the world's highest prevalence in northeastern Thailand and Laos. This carcinoma tends to grow slowly and to infiltrate the walls of the ducts, dissecting...

journal_title：Viral immunology

authors： Pinyosophon A,Wiwanitkit V

更新日期：2002-01-01 00:00:00

abstract：:Antigen-primed cytotoxic T lymphocytes (CTL) may express leukocyte immunoglobulin-like receptors (LILRs) and natural killer receptors (NKRs). Published work suggests that expression of some of these receptors confers survival advantage, leading to the idea that cells expressing such receptors may accumulate as an anti...

journal_title：Viral immunology

authors： Poon K,Montamat-Sicotte D,Cumberbatch N,McMichael AJ,Callan MF

更新日期：2005-01-01 00:00:00

abstract：:Avian infectious bronchitis virus (IBV), which is prevalent in many countries causing severe economic loss to the poultry industry, causes infectious bronchitis (IB) in birds. Recombinant single-chain variable fragments (scFvs) have been proven to effectively inhibit many viruses, both in vitro and in vivo, and they c...

journal_title：Viral immunology

authors： Lin Y,Li B,Ye J,Wang M,Wang J,Zhang Y,Zhu J

更新日期：2015-09-01 00:00:00

abstract：:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...

journal_title：Viral immunology

authors： Komatsu T,Barna M,Reiss CS

更新日期：1997-01-01 00:00:00

abstract：:A paresis isolate of equid herpesvirus 1 (EHV1, Ab4/8) and a plaque-purified virus derived from it (EHV1, Ab4/13), induced long-term suppression of both mitogenic and antigen-specific lymphocyte proliferations in adult outbred ponies. Peripheral blood mononuclear cells (PBMC) taken from a pony after EHV1 infection sup...

journal_title：Viral immunology

authors： Hannant D,O'Neill T,Ostlund EN,Kydd JH,Hopkin PJ,Mumford JA

更新日期：1999-01-01 00:00:00

abstract：:Insights into the host factors that contribute to an effective antiviral immune response may be obtained by examining global gene expression in simian human immunodeficiency virus (SHIV)-infected nonhuman primates that exhibit different virological outcomes. Immune responses and gene expression profiles in peripheral ...

journal_title：Viral immunology

authors： Chung HK,Pise-Masison CA,Radonovich MF,Brady J,Lee JK,Cheon SY,Markham P,Cristillo A,Pal R

更新日期：2008-12-01 00:00:00

abstract：:Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication ef...

journal_title：Viral immunology

authors： Hao C,Wang J,Kang W,Xie Y,Zhou Y,Ma L,Peng M,Bai X,Lian J,Jia Z

更新日期：2013-10-01 00:00:00

abstract：:Immunization with hepatitis B vaccine is an effective measure for prevention and control of hepatitis B Virus (HBV) infection. Although lots of efforts to improve the effect of hepatitis B vaccine have been made, the function of human beta defensin 2 (hBD2) on hepatitis B vaccine keeps unclear. In this article, we rep...

journal_title：Viral immunology

authors： Wang M,Zeng W,Zhang Z,Zhang W,Su H,Zhang Z,Jiang L,Liu Y,Shi Q

更新日期：2020-12-28 00:00:00

abstract：:Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...

journal_title：Viral immunology

authors： Gruber A,Chalmers AS,Rasmussen RA,Ong H,Popov S,Andersen J,Hu SL,Ruprecht RM

更新日期：2007-04-01 00:00:00

abstract：:A 90-amino acid peptide from the simian rotavirus SA-11 nonstructural protein, NSP4 was linked to the N-terminus of the Ricinus communis A-B toxin B subunit protein (RTB) and synthesized in Escherichia coli. Recombinant RTB and the NSP4(90)::RTB fusion protein bound artificial receptor glycoprotein asialofetuin in an ...

journal_title：Viral immunology

authors： Choi NW,Estes MK,Langridge WH

更新日期：2006-04-01 00:00:00

abstract：:Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...

journal_title：Viral immunology

authors： Dinca L,Neuwirth S,Schulman J,Bona C

更新日期：1993-04-01 00:00:00

abstract：:The ability of porcine reproductive and respiratory syndrome virus (PRRSV) to suppress T cell expression of CD25 (alpha chain of interleukin [IL]-2 receptor), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) was determined by flow cytometry in naive porcine T cells in response to mitogen (conc...

journal_title：Viral immunology

authors： Charerntantanakul W,Platt R,Roth JA

更新日期：2006-01-01 00:00:00

abstract：:This study was aimed at investigating the genes that control host responses to Marek's disease virus (MDV). Spleen tissues from infected and age-matched uninfected control chickens were examined 4, 7, 14, and 21 d postinfection for gene expression differences, using both microarray and quantitative real-time polymeras...

journal_title：Viral immunology

authors： Sarson AJ,Abdul-Careem MF,Zhou H,Sharif S

更新日期：2006-01-01 00:00:00

abstract：:The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

journal_title：Viral immunology

authors： Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

更新日期：2005-01-01 00:00:00

abstract：:To study IgG-specific subclasses of hepatitis B virus (HBV) surface antigen (anti-HBs), in different populations in Taiwan, a comparison was made between 104 chronic carriers (60 male and 44 female) and 439 recovered individuals (247 male and 192 female). Biochemical analyses of aspartate aminotransferase (AST) and al...

journal_title：Viral immunology

authors： Tsai TH,Huang CF,Wei JC,Ho MS,Wang L,Tsai WY,Lin CC,Xu FL,Yang CC

更新日期：2006-07-01 00:00:00

abstract：:Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...

journal_title：Viral immunology

authors： Liang SH,Rieber P,Prewett M,Riethmüller G,Pletcher C,Hoxie J,Koprowski H,Herlyn D

更新日期：1991-07-01 00:00:00

abstract：:The cytokine profile associated with either a T helper 1 (Th1) or Th2 response in a porcine respiratory disease model was assessed by measuring IL-12, IL-10 and IFN-gamma using RT-PCR and ELISA, respectively. IL-10, IL-12, and IFN-gamma levels in pulmonary alveolar macrophages and bronchial lavage fluid were increased...

journal_title：Viral immunology

authors： Thanawongnuwech R,Thacker EL

更新日期：2003-01-01 00:00:00

abstract：:Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with pla...

journal_title：Viral immunology

authors： Radu DL,Antohi S,Bot A,Weksler ME,Bona C

更新日期：1999-01-01 00:00:00

abstract：:One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the swit...

journal_title：Viral immunology

authors： Heltzel JMH,Gearhart PJ

更新日期：2020-05-01 00:00:00

abstract：:The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA an...

journal_title：Viral immunology

authors： Herrmann M,Baur A,Nebel-Schickel H,Vornhagen R,Jahn G,Krapf FE,Kalden JR

更新日期：1992-10-01 00:00:00

abstract：:Essen regimen, the Thai Red Cross two-site ID regimen, Zagreb schedule, and the eight-site ID regimen are the standard rabies vaccines recommended by the World Health Organization (WHO). In this study, a liposomal rabies vaccine (LipoRV) was developed, which was found to facilitate the production of rabies virus neutr...

journal_title：Viral immunology

authors： Miao L,Yang Y,Yan M,Li Y,Zhao J,Guo J,Zheng D

更新日期：2017-12-01 00:00:00

abstract：:The objective of this study was to investigate the immune responses elicited by either a modified-live (MLV) or a killed virus (KV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Specifically, we investigated the effects of multiple vaccinations on antigen-specific cellular and antibody responses...

journal_title：Viral immunology

authors： Bassaganya-Riera J,Thacker BJ,Yu S,Strait E,Wannemuehler MJ,Thacker EL

更新日期：2004-01-01 00:00:00

abstract：:To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...

journal_title：Viral immunology

authors： Yin J,Jin H,Kang Y,Xiao C,Zhao L,Li X,Ding Z,Yang F,Zhu Q,Wang B

更新日期：2006-07-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be an economically important infectious disease of swine. Mechanisms governing activation of the innate immune response to PRRSV remain to be elucidated. Virulence differences observed between PRRSV isolates have been attributed to replication ab...

journal_title：Viral immunology

authors： Loving CL,Brockmeier SL,Vincent AL,Lager KM,Sacco RE

更新日期：2008-09-01 00:00:00

abstract：:Hepatitis E virus (HEV) is one of the primary causative agents of acute hepatitis. It is noteworthy that HEV can develop chronic infection and even lead to liver cirrhosis; however, the mechanism has not been revealed. In this study, the ELISA assay was used to detect protein levels, and we found that HEV open reading...

journal_title：Viral immunology

authors： Lei Q,Li L,Cai J,Huang W,Qin B,Zhang S

更新日期：2016-03-01 00:00:00

abstract：:Toll-like receptor (TLR)3 signaling pathway is known to induce type 1 interferons (IFNs) and proinflammatory mediators leading to antiviral response against many viral infections. Double-stranded ribonucleic acid (dsRNA) has been shown to act as a ligand for TLR3 and, as such, has been a focus as a potential antiviral...

journal_title：Viral immunology

authors： Ahmed-Hassan H,Abdul-Cader MS,Ahmed Sabry M,Hamza E,Sharif S,Nagy E,Abdul-Careem MF

更新日期：2018-07-01 00:00:00

abstract：:Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...

journal_title：Viral immunology

authors： Santosuosso M,McCormick S,Xing Z

更新日期：2005-01-01 00:00:00

abstract：:The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...

journal_title：Viral immunology

authors： Spits HB,Grijsen ML,Steingrover R,Nanlohy NM,Kootstra N,Borghans JA,van Baarle D,Prins JM,Schellens IM

更新日期：2015-04-01 00:00:00

abstract：:Reovirus has previously been classified into three serotypes based on hemagglutination inhibition assays. In the present study, the specificity of cytotoxic T lymphocytes (CTL) generated in reovirus type 3-infected C3H/HeN mice was investigated at the population and clonal levels. Short-term CTL lines generated in res...

journal_title：Viral immunology

authors： Hogan KT,Cashdollar LW

更新日期：1991-10-01 00:00:00