Abstract:
:In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infection. The ADE of virus infection is a phenomenon in which virus-specific antibodies enhance the entry of virus, and in some cases the replication of virus, into monocytes/macrophages and granulocytic cells through interaction with Fc and/or complement receptors. This phenomenon has been reported in vitro and in vivo for viruses representing numerous families and genera of public health and veterinary importance. These viruses share some common features such as preferential replication in macrophages, ability to establish persistence, and antigenic diversity. For some viruses, ADE of infection has become a great concern to disease control by vaccination. Consequently, numerous approaches have been made to the development of vaccines with minimum or no risk for ADE. Identification of viral epitopes associated with ADE or neutralization is important for this purpose. In addition, clear understanding of the cellular events after virus entry through ADE has become crucial for developing efficient intervention. However, the mechanisms of ADE still remain to be better understood.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Tirado SM,Yoon KJdoi
10.1089/088282403763635465subject
Has Abstractpub_date
2003-01-01 00:00:00pages
69-86issue
1eissn
0882-8245issn
1557-8976journal_volume
16pub_type
杂志文章,评审相关文献
VIRAL IMMUNOLOGY文献大全abstract::Findings coming from autopsies and serum of SARS patients suggest an important immune-inflammatory implication in the evolution to respiratory distress. Conditions such as HIV infection or treatment with immunosuppressors (in cancer or autoimmune diseases) are not among the bad prognosis factors for development of dis...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2004.17.535
更新日期:2004-01-01 00:00:00
abstract::Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1995.8.165
更新日期:1995-01-01 00:00:00
abstract::Fowl aviadenoviruses (FAdVs) are distributed worldwide in poultry farms. Some FAdVs are the causative agents of inclusion body hepatitis and hydropericardium syndrome that cause significant economic losses to the poultry industry. In contrast with human adenovirus, the study of the molecular biology of FAdV is still f...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0068
更新日期:2017-11-01 00:00:00
abstract::Bacterial flagellin is a potent adjuvant that enhances adaptive immune responses to a variety of protein antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore we evaluated the humoral res...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0107
更新日期:2010-04-01 00:00:00
abstract::Most strategies for reducing global measles morbidity and mortality and eliminating measles are based on the ability to enhance immune responses to measles virus. Challenges to measles elimination and eradication are based in part on the need to sustain high levels of population immunity to interrupt transmission of m...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/08828240152716556
更新日期:2001-01-01 00:00:00
abstract::Antiidiotypic antibodies can be envisioned as an alternative approach in the development of vaccines against influenza virus, which exhibits natural antigenic variations. In our work, we obtained two polyclonal cross-reactive anti-Id antibodies against PY102, VM113, and VM202 mAbs, which in turn are specific respectiv...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1993.6.75
更新日期:1993-04-01 00:00:00
abstract::It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1987.1.135
更新日期:1987-01-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be an economically important infectious disease of swine. Mechanisms governing activation of the innate immune response to PRRSV remain to be elucidated. Virulence differences observed between PRRSV isolates have been attributed to replication ab...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0038
更新日期:2008-09-01 00:00:00
abstract::To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0093
更新日期:2014-04-01 00:00:00
abstract::Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To ac...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0025
更新日期:2017-07-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 5 (GP5) is the most abundant envelope glycoprotein and a key target for neutralizing antibodies. Previous studies have demonstrated that the native GP5 glycoprotein is poorly immunogenic and not able to induce robust protective responses, probabl...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0041
更新日期:2014-09-01 00:00:00
abstract::A molecular form of soluble suppressor factor was identified in serum-free supernatant fluid of cultured peripheral blood mononuclear cells (PBMC) from patients with severe forms of papillomavirus infections (epidermodysplasia verruciformis and large treatment-resistant condyloma acuminatum). The papillomavirus-induce...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1991.4.249
更新日期:1991-01-01 00:00:00
abstract::The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282401750234529
更新日期:2001-01-01 00:00:00
abstract::The implications of sequential prime and challenge with mismatched influenza A viruses is a concern in mammals, including humans. We evaluated the ability of pigs affected with vaccine-associated enhanced respiratory disease (VAERD) to generate a humoral immune response against the heterologous challenge virus incitin...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0018
更新日期:2013-10-01 00:00:00
abstract::HIV-1 p17 is a viral cytokine that acts on preactivated, but not on resting, human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication, after binding to a cellular receptor (p17R). Here, we demonstrate that p17Rs are expressed on activated murine T cells, which respond to p17 stimu...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.177
更新日期:2006-07-01 00:00:00
abstract::Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.381
更新日期:2005-01-01 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) causes an acute, highly contagious disease of livestock. Though FMDV is very sensitive to interferon-alpha (IFN-alpha), IFN-beta, and IFN-gamma, the virus has evolved mechanisms to evade such innate responses. For instance, during acute infection, FMDV suppresses IFN-alpha productio...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0078
更新日期:2010-02-01 00:00:00
abstract::A 90-amino acid peptide from the simian rotavirus SA-11 nonstructural protein, NSP4 was linked to the N-terminus of the Ricinus communis A-B toxin B subunit protein (RTB) and synthesized in Escherichia coli. Recombinant RTB and the NSP4(90)::RTB fusion protein bound artificial receptor glycoprotein asialofetuin in an ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.54
更新日期:2006-04-01 00:00:00
abstract::Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0091
更新日期:2017-11-01 00:00:00
abstract::To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.525
更新日期:2006-07-01 00:00:00
abstract::Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1996.9.51
更新日期:1996-01-01 00:00:00
abstract::Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2012.0001
更新日期:2012-06-01 00:00:00
abstract::During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.1989.2.263
更新日期:1989-01-01 00:00:00
abstract::The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns, resulting in the induction of innate immune responses. Viral RNA in...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2016.0178
更新日期:2017-07-01 00:00:00
abstract::Insights into the host factors that contribute to an effective antiviral immune response may be obtained by examining global gene expression in simian human immunodeficiency virus (SHIV)-infected nonhuman primates that exhibit different virological outcomes. Immune responses and gene expression profiles in peripheral ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0076
更新日期:2008-12-01 00:00:00
abstract::Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC fu...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2011.0025
更新日期:2011-10-01 00:00:00
abstract::Pretreatment of mice iv with syngeneic spleen cells modified with soluble HSV envelope antigens induced an anti-HSV antibody hyporesponsiveness following challenge with infectious virus. The epitope density on the HSV-modified spleen cells was quantitated using a photon-counting spectrofluorimeter so that observed imm...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1992.5.113
更新日期:1992-07-01 00:00:00
abstract::Astroviruses are one of the leading causes of acute viral enteritis in infants, and are recognized as a clinically important pathogen in the elderly and the immunocompromised. In spite of this, we still know very little about the immune response to astrovirus infection. Clinical observations and human volunteer studie...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.11
更新日期:2005-01-01 00:00:00
abstract::Synthetic oligodeoxynucleotides (ODNs) such as CpG can stimulate B and plasmacytoid dendritic cells in vertebrate immune systems. Several studies showed that non-CpG ODNs could also induce strong stimulation of B and T cells. PyNTTTTGT ODNs, non-CpG ODNs, can activate and cause immunoglobulin secretion by B cells and ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0073
更新日期:2009-04-01 00:00:00
abstract::Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0127
更新日期:2014-08-01 00:00:00