当前位置： SCI文献检索 > VIRAL IMMUNOLOGY期刊下所有文献 > Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe.

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe.

Abstract：

:This study aimed to investigate the seroprevalence of cytomegalovirus (CMV) infection and risk factors associated with CMV acquisition among pregnant women in Zimbabwe. In a cross-sectional study, pregnant women were recruited in late gestation, seeking antenatal care at council clinics in three high-density suburbs in Harare, Zimbabwe. Anti-CMV IgM and IgG antibodies were quantified in serum using an enzyme-linked immunosorbent assay. Antibody avidity tests were used to distinguish active infection from viral reactivation in anti-CMV IgM-positive cases. Five hundred and twenty four women were recruited: 278 HIV infected and 246 HIV uninfected. Current or active CMV infection defined as IgM positive+low avidity was detected in 4.6% (24/524), 95% confidence interval (CI): 3-6.9 in all women, 5.8% (16/278) in the HIV infected and 3.3% (8/246), 95% CI: 1.4-6.3 in the HIV uninfected. IgG seroprevalence was 99.6% (522/524), 95% CI: 98.6-99.9 in all women. Notably, the difference in the prevalence of active CMV infection between the HIV-infected and HIV-uninfected women was not statistically significant (p = 0.173). The study shows a low prevalence of primary or active CMV infection among the pregnant women, but the IgG seroprevalence suggests high previous CMV exposure. Importantly, CMV seroprevalence was not associated with the HIV status of the women, perhaps due to the ubiquitous exposure of the population to CMV.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Mhandire D,Duri K,Kaba M,Mhandire K,Musarurwa C,Chimusa E,Munjoma P,Mazengera L,Stray-Pedersen B,Dandara C

doi

10.1089/vim.2019.0024

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

289-295

issue

7

eissn

0882-8245

issn

1557-8976

journal_volume

32

pub_type

杂志文章

相关文献

VIRAL IMMUNOLOGY文献大全
  • A truncated plasmid-encoded HIV-1 reverse transcriptase displays strong immunogenicity.

    abstract：:Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. In this study, we explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy fo...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0083

    authors： Hallengärd D,Wahren B,Bråve A

    更新日期：2013-04-01 00:00:00

  • Mapping of B-cell epitopes in the nucleocapsid protein of Puumala hantavirus.

    abstract：:Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282402317340323

    authors： Lundkvist A,Meisel H,Koletzki D,Lankinen H,Cifire F,Geldmacher A,Sibold C,Gött P,Vaheri A,Krüger DH,Ulrich R

    更新日期：2002-01-01 00:00:00

  • The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus.

    abstract：:Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0098

    authors： Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

    更新日期：2018-05-01 00:00:00

  • The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

    abstract：:We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2011.0091

    authors： Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

    更新日期：2012-06-01 00:00:00

  • Adenoviral vectors for mucosal vaccination against infectious diseases.

    abstract：:Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that prefer...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2005.18.283

    authors： Santosuosso M,McCormick S,Xing Z

    更新日期：2005-01-01 00:00:00

  • Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.

    abstract：:CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2010.0076

    authors： Srikiatkhachorn A,Chintapalli J,Liu J,Jamaluddin M,Harrod KS,Whitsett JA,Enelow RI,Ramana CV

    更新日期：2010-12-01 00:00:00

  • Identification of an immunodominant peptide in the parvovirus B19 VP1 unique region able to elicit a long-lasting immune response in humans.

    abstract：:The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282401750234529

    authors： Zuffi E,Manaresi E,Gallinella G,Gentilomi GA,Venturoli S,Zerbini M,Musiani M

    更新日期：2001-01-01 00:00:00

  • A small animal model for mother-to-fetus transmission of ts1, a murine retrovirus.

    abstract：:Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282403322017929

    authors： Chakraborty J,Clark S,Okonta H,Duggan J

    更新日期：2003-01-01 00:00:00

  • Evaluation of NLRC4, NLRP1, and NLRP3, as Components of Inflammasomes, in Chronic Hepatitis B Virus-Infected Patients.

    abstract：:Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0045

    authors： Askari A,Nosratabadi R,Khaleghinia M,Zainodini N,Kennedy D,Shabani Z,Kazemi Arababadi M

    更新日期：2016-11-01 00:00:00

  • Ricin toxin B subunit enhancement of rotavirus NSP4 immunogenicity in mice.

    abstract：:A 90-amino acid peptide from the simian rotavirus SA-11 nonstructural protein, NSP4 was linked to the N-terminus of the Ricinus communis A-B toxin B subunit protein (RTB) and synthesized in Escherichia coli. Recombinant RTB and the NSP4(90)::RTB fusion protein bound artificial receptor glycoprotein asialofetuin in an ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.54

    authors： Choi NW,Estes MK,Langridge WH

    更新日期：2006-04-01 00:00:00

  • Neutralization Analysis of a Chicken Single-Chain Variable Fragment Derived from an Immune Antibody Library Against Infectious Bronchitis Virus.

    abstract：:Avian infectious bronchitis virus (IBV), which is prevalent in many countries causing severe economic loss to the poultry industry, causes infectious bronchitis (IB) in birds. Recombinant single-chain variable fragments (scFvs) have been proven to effectively inhibit many viruses, both in vitro and in vivo, and they c...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0104

    authors： Lin Y,Li B,Ye J,Wang M,Wang J,Zhang Y,Zhu J

    更新日期：2015-09-01 00:00:00

  • Severe acute respiratory syndrome, a pathological immune response to the new coronavirus--implications for understanding of pathogenesis, therapy, design of vaccines, and epidemiology.

    abstract：:Findings coming from autopsies and serum of SARS patients suggest an important immune-inflammatory implication in the evolution to respiratory distress. Conditions such as HIV infection or treatment with immunosuppressors (in cancer or autoimmune diseases) are not among the bad prognosis factors for development of dis...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2004.17.535

    authors： Bermejo JF,Muñoz-Fernandez MA

    更新日期：2004-01-01 00:00:00

  • The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza.

    abstract：:Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2017.0138

    authors： Smith AM,Huber VC

    更新日期：2018-03-01 00:00:00

  • Use of Synthetic Peptides and Multiple Antigen Blot Assay in the Immunodiagnosis of Hepatitis C Virus Infection.

    abstract：:Acute hepatitis C virus (HCV) infection is usually asymptomatic, therefore, early diagnosis is rare. It may remain undiagnosed in individuals who progress to chronic infection, often until serious liver damage has developed. To incorporate the diagnosis of this viral disease in a multiple-diagnostic assay, we first an...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2018.0023

    authors： Gauna A,Losada S,Lorenzo M,Toledo M,Bermúdez H,D'Angelo P,Sánchez D,Noya O

    更新日期：2018-10-01 00:00:00

  • Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus.

    abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be an economically important infectious disease of swine. Mechanisms governing activation of the innate immune response to PRRSV remain to be elucidated. Virulence differences observed between PRRSV isolates have been attributed to replication ab...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2008.0038

    authors： Loving CL,Brockmeier SL,Vincent AL,Lager KM,Sacco RE

    更新日期：2008-09-01 00:00:00

  • Delayed administration of interleukin-12 is efficacious in promoting recovery from lethal viral encephalitis.

    abstract：:Vesicular stomatitis virus (VSV) applied intranasally to mice initially infects the olfactory receptor neurons, and then spreads quickly to the rest of the central nervous system (CNS). Previously, we have shown that the cytokine interleukin-12 (IL-12) has a significant survival and recovery promoting effect in mice i...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1999.12.35

    authors： Ireland DD,Bang T,Komatsu T,Reiss CS

    更新日期：1999-01-01 00:00:00

  • Demonstration of the in vitro antiviral properties of bovine lymphokine-activated killer (LAK) cells.

    abstract：:In cattle, cells with functional characteristics similar to those of natural killer (NK) cells are difficult to detect. However, lymphokine-activated killer (LAK) cells can be detected readily after in vitro activation of peripheral blood mononuclear leukocytes (PBML) with interleukin-2 (IL-2). In the present study, w...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1991.4.259

    authors： Campos M,Ohmann HB,Rapin N,Babiuk LA

    更新日期：1991-01-01 00:00:00

  • Differential regulation of CXCR4 and CCR5 expression by interleukin (IL)-4 and IL-13 is associated with inhibition of chemotaxis and human immunodeficiency Virus (HIV) type 1 replication but not HIV entry into human monocytes.

    abstract：:Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.409

    authors： Creery D,Weiss W,Graziani-Bowering G,Kumar R,Aziz Z,Angel JB,Kumar A

    更新日期：2006-07-01 00:00:00

  • To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

    abstract：:As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/088282402317340260

    authors： He Y,Katze MG

    更新日期：2002-01-01 00:00:00

  • HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens.

    abstract：:HIV-1 p17 is a viral cytokine that acts on preactivated, but not on resting, human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication, after binding to a cellular receptor (p17R). Here, we demonstrate that p17Rs are expressed on activated murine T cells, which respond to p17 stimu...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.177

    authors： Fiorentini S,Becker PD,Marini E,Marconi P,Avolio M,Tosti G,Link C,Manservigi R,Guzman CA,Caruso A

    更新日期：2006-07-01 00:00:00

  • Better protective effects in rhesus macaques by combining systemic and mucosal application of a dual component vector vaccine after rectal SHIV89.6P challenge compared to systemic vaccination alone.

    abstract：:In this study we investigated the efficacy of a multigenic DNA prime/modified vaccinia Ankara (MVA)boost vaccine approach, followed by mucosal challenge with highly pathogenic simian-human immunodeficiency virus (SHIV) 89.6P, using different routes for vaccine delivery. After three times of DNA priming (SIVmac239, Gag...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0103

    authors： Stolte-Leeb N,Bieler K,Kostler J,Heeney J,Haaft PT,Suh YS,Hunsmann G,Stahl-Hennig C,Wagner R

    更新日期：2008-06-01 00:00:00

  • Very virulent plus strains of MDV induce an acute form of transient paralysis in both susceptible and resistant chicken lines.

    abstract：:Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly cell-associated alpha herpesvirus, Marek's disease virus (MDV). Clinical signs of MD include depression, crippling, weight loss, and transient paralysis (TP). TP is a disease of the central nervous system that affects MD-susc...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0003

    authors： Xu M,Fitzgerald SD,Zhang H,Karcher DM,Heidari M

    更新日期：2012-08-01 00:00:00

  • High thymic volume is associated with viral replication and immunologic impairment only early after HAART interruption in chronic HIV infection.

    abstract：:One of the strategies that has been investigated to reduce antiretroviral treatment toxicity in patients infected with human immunodeficiency virus (HIV) is structured treatment interruption (STI). Our aim was to analyze early viral and immune dynamics after interruption of highly active antiretroviral therapy (HAART)...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.740

    authors： Vallejo A,Valladares A,De Felipe B,Vivancos J,Gutierrez S,Soriano-Sarabia N,Ruiz-Mateos E,Lissen E,Leal M

    更新日期：2005-01-01 00:00:00

  • Induction of cytotoxic T lymphocytes of heterogeneous specificities by immunization with a single peptide derived from influenza A virus.

    abstract：:We examined whether immunization with a single peptide induces cytotoxic T lymphocytes (CTLs) of heterogeneous specificities in vivo. Immunization of BALB/c mice with the peptide H2:529-537, which corresponded to amino acid residues 529-537 on the HA2 subunit transmembrane region of influenza A/Jap virus (H2N2) and po...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2000.13.73

    authors： Masaki H,Tamura M,Kurane I

    更新日期：2000-01-01 00:00:00

  • Failure of vaccine or virulent strains of canine parvovirus to induce immunosuppressive effects on the immune system of the dog.

    abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1987.1.135

    authors： Phillips TR,Schultz RD

    更新日期：1987-01-01 00:00:00

  • Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression.

    abstract：:Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282402320914539

    authors： Gopinath RS,Ambagala AP,Hinkley S,Srikumaran S

    更新日期：2002-01-01 00:00:00

  • Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression.

    abstract：:Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2013.0127

    authors： Liu Y,Zhang Z,Zhao X,Yu R,Zhang X,Wu S,Liu J,Chi X,Song X,Fu L,Yu Y,Hou L,Chen W

    更新日期：2014-08-01 00:00:00

  • Antibodies against p24 of HIV-1 in patients with systemic lupus erythematosus?

    abstract：:The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA an...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1992.5.229

    authors： Herrmann M,Baur A,Nebel-Schickel H,Vornhagen R,Jahn G,Krapf FE,Kalden JR

    更新日期：1992-10-01 00:00:00

  • Evaluation of Immunostimulatory Effects of N-(2-Hydroxy) Propyl-3-Trimethylammonium Chitosan Chloride for Improving Live Attenuated Hepatitis A Virus Vaccine Efficacy.

    abstract：:This study was to evaluate the immunostimulatory effects of N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) as an adjuvant for improving a commercial live attenuated hepatitis A virus (HAV) vaccine efficacy in mice. Mice in the experimental group were intraperitoneally immunized with a solution of HT...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0099

    authors： Tao W,Fu T,He Z,Hu R,Jia L,Hong Y

    更新日期：2017-03-01 00:00:00

  • Interleukin-12 promotes recovery from viral encephalitis.

    abstract：:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1997.10.35

    authors： Komatsu T,Barna M,Reiss CS

    更新日期：1997-01-01 00:00:00