Abstract:
:The resolution revolution of cryo-electron microscopy (cryo-EM) has made a significant impact on the structural analysis of the Pneumoviridae multifunctional RNA polymerases. In recent months, several high-resolution structures of apo RNA polymerases of Pneumoviridae, which includes the human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV), have been determined by single-particle cryo-EM. These structures illustrated high similarities and minor differences between the Pneumoviridae polymerases and revealed the potential mechanisms of the Pneumoviridae RNA synthesis.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Cao D,Liang Bdoi
10.1089/vim.2020.0018subject
Has Abstractpub_date
2021-01-01 00:00:00pages
18-26issue
1eissn
0882-8245issn
1557-8976journal_volume
34pub_type
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