当前位置： SCI文献检索 > VIRAL IMMUNOLOGY期刊下所有文献 > Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2.

Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2.

Abstract：

:To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectively and sustain high levels for 1 wk in animal lungs. All animals were protected from SARS-CoV infection in preventive settings. Further, when used therapeutically this antibody led to an approximately 4-log(10) decrease in viral burden in infected animal lungs. The pathological changes in lungs correlated closely with the dose of antibody administered. The excellent preventive and therapeutic roles of equine anti-SARS-CoV F(ab')(2) in several animal models, including the novel Chinese hamster model described in this study, have provided exciting data concerning its potential clinical study.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Luo D,Ni B,Zhao G,Jia Z,Zhou L,Pacal M,Zhang L,Zhang S,Xing L,Lin Z,Wang L,Li J,Liang Y,Shi X,Zhao T,Zou L,Wu Y,Wang X

doi

10.1089/vim.2007.0038

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

495-502

issue

3

eissn

0882-8245

issn

1557-8976

journal_volume

20

pub_type

杂志文章

相关文献

VIRAL IMMUNOLOGY文献大全
  • The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice.

    abstract：:Immunization with hepatitis B vaccine is an effective measure for prevention and control of hepatitis B Virus (HBV) infection. Although lots of efforts to improve the effect of hepatitis B vaccine have been made, the function of human beta defensin 2 (hBD2) on hepatitis B vaccine keeps unclear. In this article, we rep...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2020.0052

    authors： Wang M,Zeng W,Zhang Z,Zhang W,Su H,Zhang Z,Jiang L,Liu Y,Shi Q

    更新日期：2020-12-28 00:00:00

  • Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin.

    abstract：:Highly pathogenic avian influenza (HPAI) H5N1 virus emerged in 1997 as a zoonotic disease in Hong Kong. It has since spread to Asia and Europe and is a serious threat to both the poultry industry and human health. For effective surveillance and possible prevention/control of HPAI H5N1 viruses, it is necessary to under...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2017.0020

    authors： Daidoji T,Watanabe Y,Arai Y,Kajikawa J,Hirose R,Nakaya T

    更新日期：2017-07-01 00:00:00

  • Use of Synthetic Peptides and Multiple Antigen Blot Assay in the Immunodiagnosis of Hepatitis C Virus Infection.

    abstract：:Acute hepatitis C virus (HCV) infection is usually asymptomatic, therefore, early diagnosis is rare. It may remain undiagnosed in individuals who progress to chronic infection, often until serious liver damage has developed. To incorporate the diagnosis of this viral disease in a multiple-diagnostic assay, we first an...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2018.0023

    authors： Gauna A,Losada S,Lorenzo M,Toledo M,Bermúdez H,D'Angelo P,Sánchez D,Noya O

    更新日期：2018-10-01 00:00:00

  • Transcriptional analysis of host responses to Marek's disease viral infection.

    abstract：:This study was aimed at investigating the genes that control host responses to Marek's disease virus (MDV). Spleen tissues from infected and age-matched uninfected control chickens were examined 4, 7, 14, and 21 d postinfection for gene expression differences, using both microarray and quantitative real-time polymeras...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.747

    authors： Sarson AJ,Abdul-Careem MF,Zhou H,Sharif S

    更新日期：2006-01-01 00:00:00

  • Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression.

    abstract：:Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2013.0127

    authors： Liu Y,Zhang Z,Zhao X,Yu R,Zhang X,Wu S,Liu J,Chi X,Song X,Fu L,Yu Y,Hou L,Chen W

    更新日期：2014-08-01 00:00:00

  • Clonal analysis of the cytotoxic T-lymphocyte response to reovirus.

    abstract：:Reovirus has previously been classified into three serotypes based on hemagglutination inhibition assays. In the present study, the specificity of cytotoxic T lymphocytes (CTL) generated in reovirus type 3-infected C3H/HeN mice was investigated at the population and clonal levels. Short-term CTL lines generated in res...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1991.4.167

    authors： Hogan KT,Cashdollar LW

    更新日期：1991-10-01 00:00:00

  • A truncated plasmid-encoded HIV-1 reverse transcriptase displays strong immunogenicity.

    abstract：:Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. In this study, we explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy fo...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0083

    authors： Hallengärd D,Wahren B,Bråve A

    更新日期：2013-04-01 00:00:00

  • A Molecular Approach Designed to Limit the Replication of Mature DENV2 in Host Cells.

    abstract：:Dengue virus (DENV) is an arthropod-borne virus, which belongs to the Flaviviridae family, and completes its life cycle in two hosts: humans and mosquitoes. For DENV maturation, the surface pre-membrane (prM) protein is cleaved to form a mature membrane protein (M) by furin, which is a cellular enzyme subsequently rel...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2015.0034

    authors： Raheel U,Jamal M,Zaidi NU

    更新日期：2015-09-01 00:00:00

  • Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

    abstract：:The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns, resulting in the induction of innate immune responses. Viral RNA in...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2016.0178

    authors： Okamoto M,Tsukamoto H,Kouwaki T,Seya T,Oshiumi H

    更新日期：2017-07-01 00:00:00

  • In vivo activation of toll-like receptor-9 induces an age-dependent abortive lytic cycle reactivation of murine gammaherpesvirus-68.

    abstract：:Infection of mice with murine gammaherpesvirus-68 (γHV-68) serves as a model to understand the pathogenesis of persistent viral infections, including the potential for co-infections to modulate viral latency. We have previously found that infection of neonates (8-day-old mice) with γHV-68 resulted in a high level of p...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2010.0055

    authors： Ptaschinski C,Wilmore J,Fiore N,Rochford R

    更新日期：2010-12-01 00:00:00

  • Early replication in pulmonary B cells after infection with Marek's disease herpesvirus by the respiratory route.

    abstract：:Abstract Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate t...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0047

    authors： Baaten BJ,Staines KA,Smith LP,Skinner H,Davison TF,Butter C

    更新日期：2009-12-01 00:00:00

  • Porcine reproductive and respiratory syndrome (PRRS) virus-specific interferon-gamma(+) T-cell responses after PRRS virus infection or vaccination with an inactivated PRRS vaccine.

    abstract：:Although field studies have found porcine reproductive and respiratory syndrome (PRRSV) inactivated vaccines to be beneficial in reducing losses linked to PRRSV infection, immune mechanisms induced by these vaccines need better understanding. In the study reported here, we examined the interferon-gamma(+) (IFNgamma(+)...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.381

    authors： Piras F,Bollard S,Laval F,Joisel F,Reynaud G,Charreyre C,Andreoni C,Juillard V

    更新日期：2005-01-01 00:00:00

  • COVID-19: Between Past and Present.

    abstract：:Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2020.0102

    authors： Assaf AM,Haddadin RN,Akour AA

    更新日期：2020-10-05 00:00:00

  • Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.

    abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0091

    authors： Alhetheel A,Altalhi H,Albarrag A,Shakoor Z,Mohamed D,El-Hazmi M,Somily A,Barry M,Bakhrebah M,Nassar M

    更新日期：2017-11-01 00:00:00

  • Expression of leukocyte immunoglobulin-like receptors and natural killer receptors on virus-specific CD8+ T cells during the evolution of Epstein-Barr virus-specific immune responses in vivo.

    abstract：:Antigen-primed cytotoxic T lymphocytes (CTL) may express leukocyte immunoglobulin-like receptors (LILRs) and natural killer receptors (NKRs). Published work suggests that expression of some of these receptors confers survival advantage, leading to the idea that cells expressing such receptors may accumulate as an anti...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.513

    authors： Poon K,Montamat-Sicotte D,Cumberbatch N,McMichael AJ,Callan MF

    更新日期：2005-01-01 00:00:00

  • The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus.

    abstract：:Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0098

    authors： Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

    更新日期：2018-05-01 00:00:00

  • Cytokine expression in the cervical stroma of HIV-positive and HIV-negative women with cervical intraepithelial neoplasia.

    abstract：:Cervical intraepithelial neoplasias (CINs) are a major public health issue. The prevalence of CINs is higher in women with the human immunodeficiency virus (HIV). The objective of this study was to determine whether there are differences in the immune responses in the cervical stroma of HIV-infected and -uninfected wo...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0032

    authors： Guimarães MV,Michelin MA,Lucena AA,Lodi CT,Lima MI,Murta EF,Melo VH

    更新日期：2014-09-01 00:00:00

  • ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway.

    abstract：:Hepatitis E virus (HEV) is one of the primary causative agents of acute hepatitis. It is noteworthy that HEV can develop chronic infection and even lead to liver cirrhosis; however, the mechanism has not been revealed. In this study, the ELISA assay was used to detect protein levels, and we found that HEV open reading...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2015.0107

    authors： Lei Q,Li L,Cai J,Huang W,Qin B,Zhang S

    更新日期：2016-03-01 00:00:00

  • Autoantibody idiotypy and neonatal B cell repertoire.

    abstract：:During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.1989.2.263

    authors： Sollazzo M,Glotz D,Castiglia D,Zanetti M

    更新日期：1989-01-01 00:00:00

  • To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

    abstract：:As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/088282402317340260

    authors： He Y,Katze MG

    更新日期：2002-01-01 00:00:00

  • Enhanced Immune Response to Rabies Viruses by the Use of a Liposome Adjuvant in Vaccines.

    abstract：:Essen regimen, the Thai Red Cross two-site ID regimen, Zagreb schedule, and the eight-site ID regimen are the standard rabies vaccines recommended by the World Health Organization (WHO). In this study, a liposomal rabies vaccine (LipoRV) was developed, which was found to facilitate the production of rabies virus neutr...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0093

    authors： Miao L,Yang Y,Yan M,Li Y,Zhao J,Guo J,Zheng D

    更新日期：2017-12-01 00:00:00

  • Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling.

    abstract：:Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/0882824041310568

    authors： Rodriguez JJ,Horvath CM

    更新日期：2004-01-01 00:00:00

  • Persistent effect of IFNAR-1 genetic polymorphism on the long-term pathogenesis of chronic HBV infection.

    abstract：:Genetic polymorphism of IFNAR-1 plays a large role in determining the clearance or chronicity after hepatitis B virus (HBV) exposure. However, it is not clear whether type I interferon receptor-1 (IFNAR-1) variations continuously exert their effects to influence the final outcomes following HBV chronicity, including a...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0102

    authors： He XX,Chang Y,Jiang HJ,Tang F,Meng FY,Xie QH,Li PY,Song YH,Lin JS

    更新日期：2010-06-01 00:00:00

  • Prion diseases and the spleen.

    abstract：:Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy and scrapie in sheep and goats. Transmissible spongiform encephalopathies are thought by some to result from changes in the conformation of a membrane glyco...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2004.17.334

    authors： Daude N

    更新日期：2004-01-01 00:00:00

  • Cellular gene expression profiles in rhesus macaques challenged mucosally with a pathogenic R5 tropic simian human immunodeficiency virus isolate.

    abstract：:Insights into the host factors that contribute to an effective antiviral immune response may be obtained by examining global gene expression in simian human immunodeficiency virus (SHIV)-infected nonhuman primates that exhibit different virological outcomes. Immune responses and gene expression profiles in peripheral ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2008.0076

    authors： Chung HK,Pise-Masison CA,Radonovich MF,Brady J,Lee JK,Cheon SY,Markham P,Cristillo A,Pal R

    更新日期：2008-12-01 00:00:00

  • Protective efficacy of a single dose of baculovirus hemagglutinin-based vaccine in chickens and ducks against homologous and heterologous H5N1 virus infections.

    abstract：:Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0029

    authors： Park EH,Song BM,Yum J,Kim JA,Oh SK,Kim HS,Cho GJ,Seo SH

    更新日期：2014-11-01 00:00:00

  • Mapping of B-cell epitopes in the nucleocapsid protein of Puumala hantavirus.

    abstract：:Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282402317340323

    authors： Lundkvist A,Meisel H,Koletzki D,Lankinen H,Cifire F,Geldmacher A,Sibold C,Gött P,Vaheri A,Krüger DH,Ulrich R

    更新日期：2002-01-01 00:00:00

  • Immunological characterization of respiratory syncytial virus N protein epitopes recognized by human cytotoxic T lymphocytes.

    abstract：:Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0041

    authors： Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

    更新日期：2007-09-01 00:00:00

  • High thymic volume is associated with viral replication and immunologic impairment only early after HAART interruption in chronic HIV infection.

    abstract：:One of the strategies that has been investigated to reduce antiretroviral treatment toxicity in patients infected with human immunodeficiency virus (HIV) is structured treatment interruption (STI). Our aim was to analyze early viral and immune dynamics after interruption of highly active antiretroviral therapy (HAART)...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.740

    authors： Vallejo A,Valladares A,De Felipe B,Vivancos J,Gutierrez S,Soriano-Sarabia N,Ruiz-Mateos E,Lissen E,Leal M

    更新日期：2005-01-01 00:00:00

  • Interleukin-12 promotes recovery from viral encephalitis.

    abstract：:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1997.10.35

    authors： Komatsu T,Barna M,Reiss CS

    更新日期：1997-01-01 00:00:00