Abstract：
:The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was detected in 44.4 % (FCRL1), 53.3 % (FCRL2) and 31.1 % (FCRL4) of patients. Comparatively, 31.1 % (FCRL1), 51.1 % (FCRL2) and 26.6 % (FCRL4) of controls expressed these genes. Analysis of gene expressions in FCRL-positive patients demonstrated a lower FCRL4 gene expression in patients compared to controls (P < 0.001). In FCRL2-positive patients, a significant positive correlation between FCRL2 expression and the erythrocyte sedimentation rate (P < 0.001), anti-cyclic citrullinated peptide antibody (P = 0.033) level and disease activity score (DAS28, P = 0.016) was found. In conclusion, decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to RA inflammatory processes.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Khanzadeh A,Habibagahi Z,Hosseini A,Amirghofran Zdoi
10.1007/s00296-016-3495-2subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1149-56issue
8eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-016-3495-2journal_volume
36pub_type
杂志文章abstract：:Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541361
更新日期：1984-01-01 00:00:00
abstract：:To date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4026-0
更新日期：2018-08-01 00:00:00
abstract：:The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease seve...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541162
更新日期：1982-01-01 00:00:00
abstract：:Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541352
更新日期：1985-01-01 00:00:00
abstract：:The efficacy of balneotherapy in fibromyalgia syndrome (FS) has been well demonstrated, while controlled studies using mud packs are lacking. We performed a randomized clinical trial to evaluate the effects and the tolerability of mud-bath treatment in FS patients, who are poor responders to pharmacological therapy. E...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-007-0358-x
更新日期：2007-10-01 00:00:00
abstract：:The objective of the study was to investigate the possibility whether the in vitro treatment with vitamin D3 can restore the impaired expression of protein kinase C (PKC) isoenzymes and IL-2 production in the lymphocytes of patients with systemic lupus erythematosus (SLE). Purified T lymphocytes from 14 patients with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2751-y
更新日期：2014-05-01 00:00:00
abstract：:We studied and characterized anti-bovine beta 2-glycoprotein I antibodies (aB beta 2-GPI) in sera from patients with antiphospholipid syndrome (APS) by ELISA. Bovine beta 2-glycoprotein I (beta 2-GPI) was purified by heparin affinity and DEAE ion-exchange chromatography, and identified on immunoblots using a monoclona...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00286762
更新日期：1995-01-01 00:00:00
abstract：:The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541245
更新日期：1982-01-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3957-9
更新日期：2018-04-01 00:00:00
abstract：:Most infectious agents, such as viruses, bacteria and parasites, can trigger autoimmunity via different mechanisms. The development of an autoimmune disorder after infection tends to occur in genetically susceptible individuals. Some parameters, such as genetic predisposition, feature of the infectious agent and somet...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-012-2451-z
更新日期：2012-11-01 00:00:00
abstract：:Histoplasmosis is an important cause of morbidity in endemic areas of the USA. Infection is often asymptomatic but can cause a broad spectrum of pathology. Less commonly, histoplasmosis can present with a wide-range of rheumatologic manifestations. The aim of this review is to provide a synopsis of the rheumatologic m...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-013-2816-y
更新日期：2013-12-01 00:00:00
abstract：:Arthrocutaneous disorders including Reiter's syndrome, psoriasiform rashes, and other forms of chronic arthritis and enthesopathy, such as psoriatic arthritis, occur with an increased prevalence in the setting of HIV infection. Herein we describe the spectrum and prevalence of musculoskeletal and allied skin disorders...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00271870
更新日期：1989-01-01 00:00:00
abstract：:Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflamm...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00296-016-3557-5
更新日期：2017-01-01 00:00:00
abstract：:Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1395-4
更新日期：2012-05-01 00:00:00
abstract：:Behçet's disease (BD) commonly presents with articular manifestations and thrombotic vasculopathy. Arthritis of BD characteristically demonstrates a recurrent and nondestructive course. The pathobiological basis of the thrombotic vasculopathy and protective factors against cartilage destruction in arthritis of BD have...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0324-1
更新日期：2004-03-01 00:00:00
abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2346-4
更新日期：2013-07-01 00:00:00
abstract：:Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1374-9
更新日期：2011-06-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a rare disease, and large epidemiological studies of this disease are limited. Furthermore, it has been difficult to show the incidence and characteristics of severe AOSD complications due to the rarity of this disease. The aim of our study was to describe the demographics of AOSD...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3546-8
更新日期：2016-10-01 00:00:00
abstract：:We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000095
更新日期：2001-04-01 00:00:00
abstract：:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically s...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
更新日期：2016-01-01 00:00:00
abstract：:Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease. Of the numerous organ manifestations, involvement of the upper and lower gastrointestinal tract (GIT) appears to be the most frequent with regard to the clinical symptoms. However, as the frequency and clinical relevance of GI involvement in p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1988-6
更新日期：2012-08-01 00:00:00
abstract：:The purpose of this study was to determine the association of fibromyalgia (FM) with temporomandibular disorder (TMD) and masticatory myofascial pain (MMP). Thirty-one consecutive women diagnosed as having FM according to American College of Rheumatology criteria and 21 consecutive women diagnosed as having TMD were i...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0251-z
更新日期：2007-04-01 00:00:00
abstract：:To compare oxidative stress (OS) biomarkers and antioxidant capacity of plasma (ACP) between dcSSc (diffuse cutaneous systemic sclerosis) and healthy Mexicans and their possible relationship with autoantibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid (UA). We included 28 dcSSc an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2701-8
更新日期：2013-09-01 00:00:00
abstract：:The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s002960050066
更新日期：1998-01-01 00:00:00
abstract：:Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274840
更新日期：1990-01-01 00:00:00
abstract：:The capillaroscopic pattern in paraneoplastic Raynaud's phenomenon (RP) has not been investigated systematically and is not well-defined. Here, we present three case reports of patients with paraneoplastic rheumatic conditions, manifested with severe secondary RP with emphasis upon capillaroscopic findings. The first ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1715-8
更新日期：2013-06-01 00:00:00
abstract：:The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0210-2
更新日期：2002-07-01 00:00:00
abstract：:We characterized the anemia in monkey collagen-induced arthritis (CIA) to evaluate whether this model is useful to analyze the basis of an anemia of inflammatory diseases. Cynomolgus monkey was immunized with bovine type II collagen on days 0 and 21. Blood samples were collected regularly and hematological parameters,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0547-2
更新日期：2008-07-01 00:00:00
abstract：:The authors report an unusual case of myelodysplastic syndrome (MDS) associated with ankylosing spondylitis (AS). A 40-year-old-man with MDS presented with chronic low back pain for 6 years. Four years ago, MDS was diagnosed during routine blood analysis for the work-up of his articular complaints. His initial articul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0735-0
更新日期：2009-04-01 00:00:00
abstract：:Although several effects of electromagnetic fields (EMFs) on articular cartilage have been reported in recent studies, the use of EMFs to treat osteoarthritis remains a matter of debate. In an in vitro study, human chondrocytes harvested from osteoarthritic knee joints were released from their surrounding matrix and t...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0565-0
更新日期：2008-08-01 00:00:00
