Felty syndrome: autoimmune neutropenia or immune-complex-mediated disease?

Abstract:

:Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN and the results of the Clq binding assay in FS sera. After preincubation with sera from 20 patients with FS, immunofluorescence on PMN from healthy controls (HC) showed that these cells had bound IgG, IgA, and IgM. However F(ab')2 fragments of IgG from FS sera did not bind to PMN, although the antigen-binding reactivity of the F(ab')2 fragments was maintained as shown by control experiments. Immunoglobulins eluted from FS-PMN failed to bind to HC-PMN, whereas the corresponding IgG of patients with autoimmune neutropenia was bound. Gel filtration of FS sera on Sepharose 4B showed that the binding of IgG in FS sera to PMN did not coincide with the 7S peak but occurred mainly in fractions containing larger material. No binding of IgA and IgM to HC-PMN was found after incubation with FS sera pretreated with polyethylene glycol (PEG) to precipitate immune complexes. These results indicate that in sera of patients with FS the PMN-binding reactivity of IgG, IgA, and IgM is due to the binding of immune complexes containing these immunoglobulins and not to presence of autoantibodies directed to antigens on the neutrophil surface.

journal_name

Rheumatol Int

authors

Breedveld FC,Lafeber GJ,Doekes G,Claas FH,Cats A

doi

10.1007/BF00541352

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

253-8

issue

6

eissn

0172-8172

issn

1437-160X

journal_volume

5

pub_type

杂志文章
  • Knowledge of features of inflammatory back pain in primary care in the West Midlands: a cross-sectional survey in the United Kingdom.

    abstract:KEY MESSAGES:There is a relative lack of confidence among GPs in the assessment and management of IBP vs. mechanical back pain. A simple screening tool for SpA, applicable in primary care urgently needs to be developed. It is reasonable for patients with symptoms suggestive of inflammatory back pain to be referred to s...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-018-4058-5

    authors: Adizie T,Elamanchi S,Prabu A,Pace AV,Laxminarayan R,Barkham N

    更新日期:2018-10-01 00:00:00

  • Cytokine profile in serum and synovial fluid of arthritis patients with Chlamydia trachomatis infection.

    abstract::Chlamydia trachomatis (Ct)-induced arthritis (CtIA) is characterized by persistent Ct infection, which stimulates secretion of cytokines in vitro. We therefore investigated whether CtIA patients have a unique cytokine profile in synovial fluid or serum in vivo. Because underlying Ct infection is overlooked in a high p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-003-0393-1

    authors: Jendro MC,Raum E,Schnarr S,Köhler L,Zeidler H,Kuipers JG,Martin M

    更新日期:2005-01-01 00:00:00

  • Abducens nerve palsy in a girl with incomplete Kawasaki disease.

    abstract::Kawasaki disease (KD) is a systemic vasculitis that can involve the nervous system, including the cranial nerves. Central nervous system findings, especially irritability, lethargy, and aseptic meningitis, occur in 1-30 % of KD patients (1). Cranial nerve palsies are seen rarely, and abducens nerve palsy has been repo...

    journal_title:Rheumatology international

    pub_type: 信件

    doi:10.1007/s00296-016-3515-2

    authors: Emiroglu M,Alkan G,Kartal A,Cimen D

    更新日期:2016-08-01 00:00:00

  • Nasopharyngeal sarcoidosis: a rare involvement.

    abstract::Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes a case of nasopharyngeal sarcoidosis. A 51-year-old female with ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-1866-2

    authors: Akin S,Akin S,Karadag O,Kalyoncu U,Balcı S,Ozgen B

    更新日期:2012-05-01 00:00:00

  • Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

    abstract::Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2493-2

    authors: Baker DA,Eudaly J,Smith CD,Obeid LM,Gilkeson GS

    更新日期:2013-10-01 00:00:00

  • Renal cell carcinoma presenting as Henoch-Schönlein purpura with leukocytoclastic vasculitis, hematuria, proteinuria and abdominal pain.

    abstract::Some infectious, rheumatic, allergic diseases, and malignancies have been associated with leucocytoclastic vasculitis (LCV). LCV and cancer occur most frequently in patients with hematological malignancies such as lymphomas and leukemias. There have been a few prior cases reported of LCV associated with renal cell car...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1063-8

    authors: Hong YH

    更新日期:2010-08-01 00:00:00

  • Fibromyalgia is associated to receiving chronic medications beyond appropriateness: a cross-sectional study.

    abstract::The objectives of this study are to describe appropriateness and drug treatment of comorbidities in fibromyalgia (FM). Cross-sectional study of a group of patients. Number of drugs, indication, duration and appropriateness of prescriptions were evaluated. Patients were classified as: group 1, (FM/FM) previous FM diagn...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-016-3568-2

    authors: Rivera J,Vallejo MA

    更新日期:2016-12-01 00:00:00

  • The effect of coffee, tea, and caffeine consumption on serum uric acid and the risk of hyperuricemia in Korean Multi-Rural Communities Cohort.

    abstract::Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences se...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-3061-8

    authors: Bae J,Park PS,Chun BY,Choi BY,Kim MK,Shin MH,Lee YH,Shin DH,Kim SK

    更新日期:2015-02-01 00:00:00

  • Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review.

    abstract::Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potenti...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-020-04635-z

    authors: Coskun Benlidayi I,Kurtaran B,Tirasci E,Guzel R

    更新日期:2020-10-01 00:00:00

  • Behçet's disease: immunological relevance with arthritis of ankylosing spondylitis.

    abstract::Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 a...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2446-9

    authors: Aktas Cetin E,Cosan F,Kucuksezer UC,Bilgic S,Cagatay Y,Gul A,Deniz G

    更新日期:2013-03-01 00:00:00

  • High frequency of inflammatory back pain and other features of spondyloarthritis in patients with rheumatoid arthritis.

    abstract::The aim of this study was to investigate the frequency of patients with rheumatoid arthritis (RA) who have inflammatory back pain (IBP) and meet the existing classification criteria for ankylosing spondylitis (AS) and spondyloarthritis (SpA). We included 167 patients fulfilling the ACR 1987 revised criteria for RA. Af...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2553-7

    authors: Can G,Solmaz D,Binicier O,Akar S,Birlik M,Soysal O,Akkoc N,Manisali M,Onen F

    更新日期:2013-05-01 00:00:00

  • Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural-urban gap and north-south gradient.

    abstract::During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-020-04736-9

    authors: Abualfadl E,Ismail F,Shereef RRE,Hassan E,Tharwat S,Mohamed EF,Abda EA,Radwan AR,Fawzy RM,Moshrif AH,Noor RA,Senara S,Elazim MIA,Abaza NM,Raafat HA,El-Gazzar II,El-Hammady DH,Hammam N,Gheita TA,El-Mallah R,ECR COV

    更新日期:2021-02-01 00:00:00

  • Pristane-induced arthritis in Balb/c mice. I. Clinical and histological features of the arthropathy.

    abstract::Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00541361

    authors: Hopkins SJ,Freemont AJ,Jayson MI

    更新日期:1984-01-01 00:00:00

  • Double-blind, placebo-controlled study of OM-8980 in rheumatoid arthritis.

    abstract::A total of 95 patients suffering from active rheumatoid arthritis were included in this double-blind, placebo-controlled study of the immunomodulator OM-8980. Treatment was one capsule daily of OM-8980 or placebo for 6 months. A significant improvement was observed in the OM-8980 group in comparison with the placebo g...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00270248

    authors: Hauzeur JP,Appelboom T

    更新日期:1989-01-01 00:00:00

  • Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus.

    abstract::Genetic polymorphisms in cytokine genes, which influence gene expression, may have an important impact on SLE susceptibility and severity. The aim of this study was to examine the possible influence of two functional polymorphisms in cis-regulatory regions of IL12B gene in the susceptibility and clinical symptoms of S...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1547-6

    authors: Miteva LD,Manolova IM,Ivanova MG,Rashkov RK,Stoilov RM,Gulubova MV,Stanilova SA

    更新日期:2012-01-01 00:00:00

  • Secondary neuropsychiatric manifestations caused by Epstein-Barr virus encephalitis in a new onset systemic lupus erythematosus patient.

    abstract::Abnormal manifestations of central nervous system in system lupus erythematosus (SLE) patients are mainly caused by primary neuropsychiatric SLE (NP-SLE). We reported a new onset SLE patient who had secondary neuropsychiatric manifestations caused by Epstein-Barr virus (EBV) encephalitis. Although EBV has an uncertain...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-1877-z

    authors: Hongbo C,Hongzhen M,Lingzhi H,Maosheng X,Mei C

    更新日期:2012-08-01 00:00:00

  • Managing knee osteoarthritis with yoga or aerobic/strengthening exercise programs in older adults: a pilot randomized controlled trial.

    abstract::Although exercise is often recommended for managing osteoarthritis (OA), limited evidence-based exercise options are available for older adults with OA. This study compared the effects of Hatha yoga (HY) and aerobic/strengthening exercises (ASE) on knee OA. Randomized controlled trial with three arms design was used: ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00296-016-3620-2

    authors: Cheung C,Wyman JF,Bronas U,McCarthy T,Rudser K,Mathiason MA

    更新日期:2017-03-01 00:00:00

  • Iloprost infusion does not reduce oxidative stress in systemic sclerosis.

    abstract::Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There i...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00296-007-0443-1

    authors: Volpe A,Biasi D,Caramaschi P,Bambara LM,Carletto A,Degan M,Minuz P

    更新日期:2008-02-01 00:00:00

  • Male gender results in more severe lupus nephritis.

    abstract::Gender may produce different characteristics in the manifestation of systemic lupus erythematosus (SLE). The present study investigated the influence of gender on clinical, laboratory, autoantibodies and histopathological classes of lupus nephritis (LN). As much as 81 patients diagnosed with SLE (ACR criteria) and act...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1151-9

    authors: de Carvalho JF,do Nascimento AP,Testagrossa LA,Barros RT,Bonfá E

    更新日期:2010-08-01 00:00:00

  • Spondylodiscitis due to an emergent fungal pathogen: Blastoschizomyces capitatus, a case report and review of the literature.

    abstract::The study includes a case report and a literature review. The main objective of this study is to present a case of spondylodiscitis due to a fungal pathogen, Blastoschizomyces capitatus and to review the published literature on this emergent fungus in etiology of spondylodiscitis, and osteomyelitis. Osteoarticular inv...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-009-0928-1

    authors: Celik AD,Ozaras R,Kantarcioglu S,Mert A,Tabak F,Ozturk R

    更新日期:2009-08-01 00:00:00

  • Sequelae of osteomyelitis variolosa: a case report.

    abstract::Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2194-2

    authors: Nema S,Vyas GS,Kukreja S

    更新日期:2012-11-01 00:00:00

  • OPG inhibits gene expression of RANK and CAII in mouse osteoclast-like cell.

    abstract::This study was designed to determine the effects of the osteoprotegerin (OPG) on the mRNA expression of carbonic anhydrase II (CAII) and the receptor activator of NF-κB (RANK) in mouse osteoclast-like cells. Marrow cells were harvested from femora and tibiae of mouse and cultured in 6-well chamber slides. After 1 day ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2338-4

    authors: Chen J,He JQ,Zhen SY,Huang LQ

    更新日期:2012-12-01 00:00:00

  • Seronegative Lyme arthritis.

    abstract::We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synov...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-007-0333-6

    authors: Holl-Wieden A,Suerbaum S,Girschick HJ

    更新日期:2007-09-01 00:00:00

  • Conversion rates of abstracts presented at the Canadian Rheumatology Association Annual Meetings into full-text journal articles.

    abstract::Dissemination of research studies is important for research ideas to be transformed from initial abstracts to full publications. Analyses of the scientific impact and publication record of the Canadian Rheumatology Association (CRA) Annual meeting have not been previously described. This study determines the publicati...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-017-3701-x

    authors: Yacyshyn EA,Soong LC

    更新日期:2017-06-01 00:00:00

  • A case of pure red cell aplasia and systemic lupus erythematosus caused by human parvovirus B19 infection.

    abstract::Human parvovirus B19 (B19) rarely induces pure red cell aplasia (PRCA) in healthy hosts. Meanwhile B19 infection is often clinically similar to systemic lupus erythematosus (SLE), and several cases have been reported wherein B19 actually stimulated SLE exacerbation in an immunocompetent subject. An 82-year-old healthy...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-006-0227-z

    authors: Ideguchi H,Ohno S,Ishigatsubo Y

    更新日期:2007-02-01 00:00:00

  • Acute pancreatitis and macrophage activation syndrome in pediatric systemic lupus erythematosus: case-based review.

    abstract::Pancreatitis is uncommon in systemic lupus erythematosus (SLE) and is rarely reported in children, possibly being related to macrophage activation syndrome (MAS). The incidence of MAS in children with lupus pancreatitis is unknown, as is their prognosis. In this case-based review, we report a pediatric patient with SL...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-019-04388-4

    authors: Lin Q,Zhang M,Tang H,Shen Y,Zhu Y,Xu Q,Li X

    更新日期:2020-05-01 00:00:00

  • Successful treatment with intravenous immunoglobulin of severe thrombocytopenia complicated in primary Sjögren's syndrome.

    abstract::Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1395-4

    authors: Choung BS,Yoo WH

    更新日期:2012-05-01 00:00:00

  • Cryoglobulins in cases of rheumatoid arthritis.

    abstract::Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00541520

    authors: Chattopadhya D,Ravindran B,Prakash K

    更新日期:1985-01-01 00:00:00

  • Non-Hodgkin's lymphoma following treatment with etanercept in ankylosing spondylitis.

    abstract::Anti-TNF drugs may increase lymphoma risk in autoimmune rheumatic diseases, such as rheumatoid arthritis, but there have been no reports stating increased risk of lymphoma in ankylosing spondylitis (AS). Before 2 years, we had presented a case with AS developing Hodgkin's lymphoma following 6 months of etanercept trea...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1265-0

    authors: Aksu K,Cagirgan S,Ozsan N,Keser G,Sahin F

    更新日期:2011-12-01 00:00:00

  • Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF therapy: an observational study.

    abstract::The objective of this study was to evaluate human papillomavirus (HPV) and Chlamydia trachomatis (CT) infections in RA patients pre- and post-TNF blocker. Fifty female RA patients (ACR criteria), who were eligible to anti-TNF therapy [n = 50 at baseline (BL) and n = 45 after 6 months of treatment (6 M)], and 50 age-ma...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-3157-1

    authors: Waisberg MG,Ribeiro AC,Candido WM,Medeiros PB,Matsuzaki CN,Beldi MC,Tacla M,Caiaffa-Filho HH,Bonfa E,Silva CA

    更新日期:2015-03-01 00:00:00