Abstract：
:Although several effects of electromagnetic fields (EMFs) on articular cartilage have been reported in recent studies, the use of EMFs to treat osteoarthritis remains a matter of debate. In an in vitro study, human chondrocytes harvested from osteoarthritic knee joints were released from their surrounding matrix and transferred in defined concentration into a 3D matrix (type-I collagen gel). The cultivation, performed under standard conditions, lasted up to 14 days. During this time, treatment groups were continuously exposed to either sinusoid or pulsed electromagnetic fields (PEMFs). The PEMFs revealed the following characteristics: maximum magnetic flux density of 2 mT, frequency of the bursts of 16.7 Hz with each burst consisting of 20 pulses. Similarly, the sinusoid EMFs also induced a maximum flux density of 2 mT with a frequency of 50 Hz. Control groups consisting of equal number of samples were not exposed to EMF. Immunohistological examinations of formalin-fixed, paraffin-embedded samples revealed positive staining for type-II collagen and proteoglycans in the immediate pericellular region with no differences between the two different treatment groups and the control groups. With increasing cultivation time, both type-II collagen and aggrecan gene expression declined, but no significant differences in gene expression were found between the treatment and control groups. In conclusion, using our in vitro setting, we were unable to detect any effects of pulsed and sinusoidal magnetic fields on human adult osteoarthritic chondrocytes.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Schmidt-Rohlfing B,Silny J,Woodruff S,Gavenis Kdoi
10.1007/s00296-008-0565-0subject
Has Abstractpub_date
2008-08-01 00:00:00pages
971-7issue
10eissn
0172-8172issn
1437-160Xjournal_volume
28pub_type
杂志文章abstract：:Recent studies indicate that high-mobility group box protein 1 (HMGB1) contributes to the pathogenesis of diverse autoimmune disorders. It induces the production of interferon-alpha (IFN-alpha) and tumor necrosis factor alpha (TNF-alpha) in vitro. In the present study, plasma HMGB1, TNF-alpha, and IFN-alpha were deter...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1636-6
更新日期：2012-02-01 00:00:00
abstract：:The prevalence of Takayasu's arteritis (TA) varies greatly among world populations, and little is known about this disease in Eastern Mediterranean Arab populations. We conducted a retrospective chart review of patients diagnosed with TA from 1996 to 2008 at a single large referral center in Jordan. Eight patients (se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1163-5
更新日期：2010-09-01 00:00:00
abstract：:A 7-year-old child was first admitted for persistent fever of 15-day duration and suspected meningitis. Kawasaki syndrome was lately diagnosed upon the recognition of an extensive diffuse coronary artery damage characterized by medium-sized aneurysms of the epicardial vessels. An eccentric thrombus along the inferior ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-1814-1
更新日期：2012-03-01 00:00:00
abstract：:Sarcoidosis is a chronic granulomatous inflammation. The clinical spectrum in childhood is heterogeneous. Angiotensin converting enzyme activity is used as a marker for disease activity. Human chitotriosidase is produced in macrophages. In this study, serum chitotriosidase levels were significantly higher in active sa...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-007-0318-5
更新日期：2007-10-01 00:00:00
abstract：:Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. The paraneoplastic nature should be based on specific criteria. We report a series of eight cases of paraneoplastic rheumatic syndromes revealing an underlying neoplasia. Our series consists of six men and two women, wi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2252-9
更新日期：2012-06-01 00:00:00
abstract：:Takayasu's arteritis (TA) is a rare chronic vasculitis of the aorta and its main branches. Infectious agents or autoimmunity are thought to influence the pathophysiology. Ethnic preponderance in East Asia and usually affects young Asian women suggesting a possible role of genetic factor in the etiology. We present a r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1234-7
更新日期：2011-06-01 00:00:00
abstract：:The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0461-z
更新日期：2008-03-01 00:00:00
abstract：:The aim of the study was to test the frequency of CD4+ CD25(high)FoxP3 regulatory T cells in JIA patients and to assess their activation status and functional activity. The study involved 12 children with JIA and 35 healthy control subjects. PBMC were stained with monoclonal antibodies (anti-CD25, anti-CD4, anti-CD127...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1728-3
更新日期：2012-05-01 00:00:00
abstract：:The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0920-9
更新日期：2009-11-01 00:00:00
abstract：:Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1395-4
更新日期：2012-05-01 00:00:00
abstract：:To determine the "hand anatomic index" (HAI--a quantitative measure of hand deformity) in systemic sclerosis (scleroderma) and to compare it with the other measures of hand deformity and functional impairment. The HAI (measure of open hand span minus closed hand span/lateral height of hand) was determined in 30 patien...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0058-3
更新日期：2006-03-01 00:00:00
abstract：:Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541164
更新日期：1982-01-01 00:00:00
abstract：:The aim of this study was to identify the possible determinants of impaired health-related quality of life (HRQOL) in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). Fifty-eight consecutive patients of JIA aged from 8 to 18 years underwent assessment of socio-economic and demographic charac...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-2950-1
更新日期：2014-08-01 00:00:00
abstract：:To define and give priority to standards of care and quality indicators of multidisciplinary care for patients with psoriatic arthritis (PsA). A systematic literature review on PsA standards of care and quality indicators was performed. An expert panel of rheumatologists and dermatologists who provide multidisciplinar...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3986-4
更新日期：2018-06-01 00:00:00
abstract：:Solid organ transplantation is an important lifesaving procedure mainly performed in patients with end-stage organ failure such as liver cirrhosis, congestive heart failure, and end-stage renal disease. While these complications are among the most preventable adverse effects of solid organ transplantation, these are g...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1970-3
更新日期：2012-08-01 00:00:00
abstract：:Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2493-2
更新日期：2013-10-01 00:00:00
abstract：:The group of autoimmune cutaneous connective tissue diseases (CCTD) includes systemic sclerosis, dermatomyositis (DM), lupus erythematosus (LE), and subtypes. Most CCTD patients can be assigned to one of these phenotypes or mixed forms, and transitions among the subsets exist. We present the case of a 26-year-old woma...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0354-8
更新日期：2004-03-01 00:00:00
abstract：:The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1176-0
更新日期：2010-09-01 00:00:00
abstract：:A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04414-5
更新日期：2019-12-01 00:00:00
abstract：:The aim of the study was to assess the possible association between type II collagen turnover seromarkers and disease profile in patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). Outpatients with axial SpA (n = 110) or PsA (n = 101) underwent clinical examination including disease activity mea...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3397-8
更新日期：2016-04-01 00:00:00
abstract：:Chronic inflammatory syndromes such as rheumatoid arthritis (RA) are associated with high frequencies of CD4+CD28- T cells. The number of these cells is genetically determined and may also be a consequence of chronic exposure to tumor necrosis factor-alpha (TNFalpha). The aim of this study was to examine whether the r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0374-4
更新日期：2004-11-01 00:00:00
abstract：:The aim of the study was to evaluate the frequency of extra-articular manifestations (EAMs) of rheumatoid arthritis (RA) in a series of patients from nine Italian rheumatology clinics. A total of 587 patients underwent direct questioning, complete physical evaluation, and review of medical records and laboratory data....
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/pl00006853
更新日期：2000-01-01 00:00:00
abstract：:Accumulating evidence suggests that defects in the function of CD4(+)CD25(+) regulatory T cells (Tregs) are important in immune-mediated diseases such as rheumatoid arthritis. Here, we investigated the effects of various disease-modifying anti-rheumatic drugs (DMARDs) on Treg function. Tregs and CD4(+)CD25(-) effector...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2365-9
更新日期：2013-02-01 00:00:00
abstract：:The aim of the study was to assess agreement between three-dimensional volumetric ultrasound (3D US) performed by inexperienced staff and real-time conventional ultrasound (2D US) performed by experienced rheumatologists in detecting and scoring rheumatoid arthritis (RA) lesions. Thirty-one RA patients underwent exami...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3606-0
更新日期：2017-02-01 00:00:00
abstract：:Previous studies have demonstrated an increased risk of breast cancer among patients with systemic sclerosis (scleroderma). To describe the clinical characteristics of 21 patients with both systemic sclerosis and breast cancer, and compare their risk factors to female scleroderma patients without breast cancer, in a p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0540-9
更新日期：2008-07-01 00:00:00
abstract：:Previous studies have shown that fibromyalgia syndrome (FMS) is associated with low level of physical activity and exercise, which may lead to an increased risk of osteoporosis. However, studies of bone mineral density (BMD) in fibromyalgia have shown conflicting results. Thus, we conducted a systematic review and met...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00296-016-3625-x
更新日期：2017-04-01 00:00:00
abstract：:We evaluated the frequency of secondary amyloidosis, associated clinical features, and outcomes in ankylosing spondylitis (AS) patients diagnosed in the last decade. The medical records of AS patients diagnosed at single academic medical center were reviewed for clinical evidence of amyloidosis. During routine follow-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2646-3
更新日期：2013-07-01 00:00:00
abstract：:The aim of this study was to analyze the longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica (PMR). Patients diagnosed with PMR were collected retrospectively in two rheumatology departments. In addition to demographic and diagnostic criteria, th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3014-2
更新日期：2014-10-01 00:00:00
abstract：:During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04736-9
更新日期：2021-02-01 00:00:00
abstract：:The aim of the present study was to evaluate the effects of an exercise training program on lipid profile and composition of high-density lipoprotein (HDL) subfractions in systemic lupus erythematosus (SLE) patients and healthy controls. A 12-week, randomized trial was conducted. Thirty-three physically inactive SLE p...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-014-3081-4
更新日期：2015-01-01 00:00:00
