Abstract：
:Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the same patients. Although the patients selected showed elevated levels of T cells expressing the T8 differentiation antigen as well as Ia antigens there was little demonstrable suppression of the blood B cell differentiation. Furthermore, the synovial T cells exhibited only minimal helper or inducer activity when tested in the same system. In contrast, patient's blood T lymphocytes gave levels of help and suppression that were not distinguishable from that of normal individuals. Co-culture experiments of blood and synovial T lymphocytes did not reveal any evidence for enhanced suppression; indeed, in most patients these co-cultures resulted in marked augmentation of helper function, a phenomenon designated "helper augmentation". These data provide evidence that rheumatoid synovial lymphocytes are characterized by marked abnormalities in immunoregulatory T cell function, including divergence of cellular activity from the immune function predicted by surface phenotype and a capacity for "helper augmentation", a novel T cell function in man.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Romain PL,Burmester GR,Enlow RW,Winchester RJdoi
10.1007/BF00541164subject
Has Abstractpub_date
1982-01-01 00:00:00pages
121-7issue
3eissn
0172-8172issn
1437-160Xjournal_volume
2pub_type
杂志文章abstract：:Rheumatoid arthritis (RA) in Thai population is significantly associated with HLA-DR4 shared epitope (SE) alleles, particularly with DRB1*0405 (P = 0.00004, OR = 3.84, 95% CI = 1.93, 7.7). In addition, tumor necrosis factor-alpha (TNF-alpha) gene -863A alleles were found to be significantly increased in 77 RA patients...
journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1655-3
更新日期：2012-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1614-z
更新日期：2011-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0269-2
更新日期：2007-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541200
更新日期：1984-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00296-013-2895-9
更新日期：2014-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04411-8
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To describe the prevalence of and evaluate the factors associated with fatigue patients with psoriatic arthritis (PsA) in an Asian population. METHODS:We used baseline data from a registry of patients with PsA attending an outpatient clinic of a tertiary hospital in Singapore. Demographic data and disease ch...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04678-2
更新日期：2020-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0105-8
更新日期：2006-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0970-z
更新日期：2010-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2374-8
更新日期：2013-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
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更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0458-7
更新日期：2008-03-01 00:00:00
abstract：:To investigate the effects of TNF-alpha -308, -238 promoter polymorphisms on TNF-alpha transcription in B27 positive Chinese patients with ankylosing spondylitis (AS). The possible relationship between polymorphisms, MHC antigens, and quantitative TNF-alpha mRNA expression were evaluated. Single nucleotide polymorphis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0671-z
更新日期：2008-12-01 00:00:00
abstract：:The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s002960050066
更新日期：1998-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0354-8
更新日期：2004-03-01 00:00:00
abstract：:There are no standardized bedside assessments for subtyping patients with osteoarthritis (OA) based on pain mechanisms. Thus, we developed a bedside sensory testing kit (BSTK) to classify OA patients based on sensory profiles potentially indicative of pain mechanism. After usability and informal reliability testing (n...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3191-z
更新日期：2015-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-006-0241-1
更新日期：2007-03-01 00:00:00
abstract：:Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-1145-7
更新日期：2011-01-01 00:00:00
abstract：:The current study was to investigate the quantity and quality of researches in the field of ankylosing spondylitis, and to reveal the characteristics of worldwide productivity on this disease. This was a bibliometric study on ankylosing spondylitis using Web of Science. The numbers of papers, citations, research outpu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04308-6
更新日期：2019-06-01 00:00:00
abstract：:There are numerous causes of pulmonary cavitary lesions as infection (bacterial, parasitic and invasive fungal), Wegener granulomatosis (WG) and other vasculitis, sarcoidosis, malignancy, septic thromboembolism, airways disease (cystic bronchiectasis and bullae), pneumatoceles and traumatic parenchymal laceration. Her...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-012-2424-2
更新日期：2013-08-01 00:00:00
