Abstract：
:To determine the "hand anatomic index" (HAI--a quantitative measure of hand deformity) in systemic sclerosis (scleroderma) and to compare it with the other measures of hand deformity and functional impairment. The HAI (measure of open hand span minus closed hand span/lateral height of hand) was determined in 30 patients with scleroderma and compared with hand deformity (as assessed by two independent rheumatologists) and with the Health Assessment Questionnaire (mHAQ), hand strength and prehensile gripability data. The HAI was confirmed as a reliable measure which clearly distinguished patients with increasing hand deformity and separated patients with diffuse scleroderma (n=12) from limited scleroderma (n=18), P=0.005. The HAI correlated significantly with measures of global functional impairment (as measured by the mHAQ) r=-0.46, P=0.01, hand strength r=0.51, P=0.0001 and prehensile gripability, r=-0.37, P=0.05 but neither with disease duration r=-0.16, P=NS nor age at disease onset r=0.20, P=NS. It was estimated that the HAI accounts for ~25% of the total global disability (as measured by HAQ). Measurement of the HAI in scleroderma provides a reliable and objective measure reflecting variable degrees of hand deformity and functional impairment and might provide a valid clinical outcome measure in patients with this disabling disorder.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Roberts-Thomson AJ,Massy-Westropp N,Smith MD,Ahern MJ,Highton J,Roberts-Thomson PJdoi
10.1007/s00296-005-0058-3subject
Has Abstractpub_date
2006-03-01 00:00:00pages
439-44issue
5eissn
0172-8172issn
1437-160Xjournal_volume
26pub_type
杂志文章abstract：:IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274884
更新日期：1991-01-01 00:00:00
abstract：:It is proposed that synovial fluid biomarkers may help in differentiating the type of arthritis. The aim of study is to determine whether synovial fluid adenosine deaminase (ADA) and high-sensitivity C-reactive protein (hs-CRP) can be useful in this regard. A total of 75 patients with knee monoarthritis that were admi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1602-3
更新日期：2012-01-01 00:00:00
abstract：:Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050033
更新日期：1998-01-01 00:00:00
abstract：:An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3774-6
更新日期：2017-10-01 00:00:00
abstract：:The objective of the study is to assess the disease course and associated healthcare costs in a cohort of established rheumatoid arthritis (RA) patients in Turkey. The study cohort consisted of 75 RA patients from our outpatient clinic who took part in a previous multicenter study assessing RA-related healthcare costs...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04574-9
更新日期：2020-07-01 00:00:00
abstract：:A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/BF00290280
更新日期：1993-01-01 00:00:00
abstract：:Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There i...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-007-0443-1
更新日期：2008-02-01 00:00:00
abstract：:Although several effects of electromagnetic fields (EMFs) on articular cartilage have been reported in recent studies, the use of EMFs to treat osteoarthritis remains a matter of debate. In an in vitro study, human chondrocytes harvested from osteoarthritic knee joints were released from their surrounding matrix and t...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0565-0
更新日期：2008-08-01 00:00:00
abstract：:The main goal of this project was to identify the presence of fibromyalgia (FM) subgroups using a simple and frequently used clinical tool, the Fibromyalgia Impact Questionnaire (FIQ). A total of 61 women diagnosed with FM participated in this study. FM subgroups were created by applying a hierarchical cluster analysi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0722-5
更新日期：2009-03-01 00:00:00
abstract：:This study was designed to investigate the association of oral ulceration and oral health factors, together with psycho-social well-being in Behçet's disease (BD), and to clarify the importance of psycho-social support of patients in the overall management of BD. The study comprised of a cohort of 146 BD patients (mea...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4117-y
更新日期：2018-10-01 00:00:00
abstract：:Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (tota...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0502-9
更新日期：2005-05-01 00:00:00
abstract：:To investigate the efficacy of etanercept and MTX (methotrexate) combination therapy in Chinese patients with ankylosing spondylitis hip joint lesion, the possible courses and maintenance protocol, altogether 97 ankylosing spondylitis patients fulfilling the modified New York criteria with hip joint lesion were enroll...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1844-8
更新日期：2012-06-01 00:00:00
abstract：:Some infectious, rheumatic, allergic diseases, and malignancies have been associated with leucocytoclastic vasculitis (LCV). LCV and cancer occur most frequently in patients with hematological malignancies such as lymphomas and leukemias. There have been a few prior cases reported of LCV associated with renal cell car...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1063-8
更新日期：2010-08-01 00:00:00
abstract：:Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction a...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04457-8
更新日期：2020-01-01 00:00:00
abstract：:Although arthroscopic surgery (AS) for knee osteoarthritis has been widely employed, scientific evidence is lacking. The purpose of this study was to investigate temporal changes in synovial fluid levels of biochemical markers associated with cartilage metabolism following AS. Twenty-five knees of 24 patients with med...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2374-8
更新日期：2013-01-01 00:00:00
abstract：:Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2821-1
更新日期：2013-11-01 00:00:00
abstract：:To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological gui...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3201-1
更新日期：2015-06-01 00:00:00
abstract：:We determined whether repeated treatment with the tumor necrosis factor-α (TNF-α) antagonist etanercept can be effective after an initial clinical response to this drug is lost. We describe three female patients with active, refractory rheumatoid arthritis who were administered with a second course of etanercept after...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2124-3
更新日期：2012-11-01 00:00:00
abstract：:Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04386-6
更新日期：2019-09-01 00:00:00
abstract：:31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00291145
更新日期：1991-01-01 00:00:00
abstract：:Alkoptunuria is an inherited autosomal recessive metabolic disorder which is caused by the lack of homogentisic acid-oxidase enzyme. It is associated with various systemic abnormalities and related to the deposition of homogentisic acid pigment in connective tissues. These pigmentary changes are termed "ochronosis". W...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0538-x
更新日期：2005-08-01 00:00:00
abstract：:Fibromyalgia (FM) is a common chronic pain syndrome with an unknown etiology. Recent years added new information to our understanding of FM pathophysiology. Researches on genetics, biogenic amines, neurotransmitters, hypothalamic-pituitary-adrenal axis hormones, oxidative stress, and mechanisms of pain modulation, cen...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-005-0078-z
更新日期：2006-05-01 00:00:00
abstract：:Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4090-5
更新日期：2018-08-01 00:00:00
abstract：:Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0357-5
更新日期：2004-07-01 00:00:00
abstract：:To evaluate the efficacy and safety of infliximab biosimilar CT-P13 in patients with active Takayasu arteritis (TAK). In this single-center open-label trial, patients with active TAK received CT-P13 at a starting dose of 5 mg/kg at weeks 0, 2, 6, and then every 8 weeks up to week 46. They were followed up until week 5...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-018-4159-1
更新日期：2018-12-01 00:00:00
abstract：:The FRAX tool that calculates the 10-year probability of having a fracture has recently been validated for Belgium. Little is known about the perception and knowledge that GPs have about this tool in their daily practice. A survey has been conducted as part of a screening campaign for various diseases. The primary obj...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2461-x
更新日期：2013-04-01 00:00:00
abstract：:Objective of the study is to investigate how compliance during the first year of methotrexate (MTX) treatment in rheumatoid arthritis (RA) is influenced by the patients' perception of the necessity for and concern about MTX, the patients' functional disability, and the dose of MTX. A total of 126 RA patients completed...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1160-8
更新日期：2010-09-01 00:00:00
abstract：:The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the ne...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1672-2
更新日期：2011-08-01 00:00:00
abstract：:We have recently reported on two cases of scleroderma patients with ANCA-associated vasculitis for the first time in Korea. In order to explore the nature of this disease combination, we pooled together all the previously known cases and statistically analyzed them. Out of the 50 selected cases, survival analysis was ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-005-0011-5
更新日期：2006-03-01 00:00:00
abstract：:Psychiatric manifestations are common in systemic lupus erythematosus (SLE) and often represent a challenging diagnostic and therapeutic problem, mainly because the uncertainties of the pathogenic mechanisms. We report a case of acute psychosis occurring in a female with SLE due to the stress of having a severe diseas...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0479-2
更新日期：2008-02-01 00:00:00
