Abstract:
:Although arthroscopic surgery (AS) for knee osteoarthritis has been widely employed, scientific evidence is lacking. The purpose of this study was to investigate temporal changes in synovial fluid levels of biochemical markers associated with cartilage metabolism following AS. Twenty-five knees of 24 patients with medial knee osteoarthritis (mean age 70.5 years) were included in this study. Synovial fluids were sampled immediately before surgery and 2, 4, 8, and 12 weeks after AS. Levels of the biochemical markers chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), and keratan sulfate (KS) were measured and correlations among the biochemical markers were analyzed before and after surgery. C6S, C4S, and total CS levels were the same before and after surgery; however, the KS level decreased significantly at 2 weeks after AS. A strong, positive correlation was detected between C6S and KS levels at 12 weeks, differing from the weaker correlation seen before surgery. Seven of the patients required total or unicompartmental knee arthroplasties in the 2 years following AS. In this study, the significant reduction in KS levels and the strong correlation between C6S and KS levels were shown, which indicates suppressed cartilage turnover after AS. Exploring predictive factors indicating favorable or unfavorable outcomes from AS will be important future studies.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Nakajima A,Nakagawa K,Aoki Y,Sonobe M,Shibata Y,Yamazaki M,Murakami Mdoi
10.1007/s00296-012-2374-8subject
Has Abstractpub_date
2013-01-01 00:00:00pages
209-14issue
1eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract::Wells' syndrome is a multifaceted dermatosis with a wide morphological spectrum, ranging from characteristic cellulitis-like erythema and papula to an unusual presentation of vesicles and pustules. The most important elements for diagnosis are erythemal plaques and histological picture of eosinophilic infiltration of ...
journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2805-1
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541214
更新日期:1984-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541352
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00296-014-2971-9
更新日期:2014-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 信件
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章
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