Abstract：
:We describe a typical case of a patient with remitting seronegative symmetrical synovitis and pitting edema (RS(3)PE) syndrome. He underwent a successful clinical course monitored by serologic variables and radiographic methods. Serum levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), matrix metalloproteinase-3 and serum amyloid A were remarkably elevated. Accumulation of inflammatory cells into the multiple joints was found by gallium-67 scintigraphy. Multiple and symmetrical tenosynovitis with hypervascularity in the presence of subcutaneous edema of the hands and feet were determined by magnetic resonance imaging (MRI) and ultrasonography. These serologic and radiographic abnormalities immediately improved after treatment with a low-dose steroid. Our present case supports a previous observation that synovial tissue is a major inflammatory source of RS(3)PE syndrome. IL-6 (and VEGF), probably produced from the synovial tissues, are considered to be essential factors in the development of RS(3)PE syndrome.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kawashiri SY,Nakano M,Kawakami A,Eguchi Kdoi
10.1007/s00296-009-1142-xsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
1677-80issue
12eissn
0172-8172issn
1437-160Xjournal_volume
30pub_type
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