Abstract:
:Familial Mediterranean fever (FMF) is an autosomal recessive, inherited autoinflammatory disease characterized by recurrent, self-limited attacks of fever and inflammation of serosal surfaces. There is an explosion of the data regarding inflammatory markers in FMF and clinical effects of chronic inflammation on the disease presentation. Vitamin D (vit D) is the common denomination of a group of sterols with a crucial role in phospho-calcium metabolism. There are some data about the importance of vit D in the initiation and propogation of a range of autoimmune diseases. The aim of the present study was to determine whether vit D deficiency is present in patients with FMF compared with healthy individuals. The study group included 99 patients with diagnosis of FMF attended to our outpatient Rheumatology and Nephrology Clinics of Atatürk Education and Research Hospital. The control group comprised 51 age- and sex-matched healthy people selected from hospital staff. Serum baseline 25-hydroxy vit D levels were measured by HPLC method using an Agilent 1100 Liquid Chromatograph. We found significantly lower serum 25-hydroxy vit D levels among FMF patients compared with matched controls and a high prevalence of vit D deficiency. This study demonstrated that vit D deficiency is frequent in patients with FMF than the healthy controls. It is convenient to look for vit D deficiency and to correct vit D nutritional status in FMF patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Erten S,Altunoğlu A,Ceylan GG,Maraş Y,Koca C,Yüksel Adoi
10.1007/s00296-011-2281-4subject
Has Abstractpub_date
2012-12-01 00:00:00pages
3845-9issue
12eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
杂志文章abstract::We report a 53-year-old Turkish female presented with progressive weakness and mild dyspnea. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis. The urinary anion gap was positive in the presence of acidemia, thus she was diagnosed with hypokalemic paralysis from a severe distal ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2322-z
更新日期:2013-07-01 00:00:00
abstract::3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301776
更新日期:1995-01-01 00:00:00
abstract::Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3385-z
更新日期:2016-03-01 00:00:00
abstract::The objective of the study was to determine whether cartilage expression of the bone regulating molecules receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) varies between the different grades of osteoarthritis (OA). Cartilage samples were obtained from 30 patients undergoing total hip/kn...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1733-6
更新日期:2012-02-01 00:00:00
abstract::Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1954-3
更新日期:2012-06-01 00:00:00
abstract:AIM:The aim of this study was to assess the efficacy of long-term azathioprine and steroids for treatment of severe nephritis in children with Henoch-Schönlein purpura (HSP). METHODS:Analysis of case records of children with HSP followed up for a mean duration of 4.7 years (range 6 months-6.5 years) was performed. All...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0208-9
更新日期:2002-08-01 00:00:00
abstract::The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is an inclusive questionnaire, able to describe the total impairments and restrictions due to axial spondyloarthritis (axSpA). Considering the relationship between ASAS HI and the Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP,...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3642-9
更新日期:2017-05-01 00:00:00
abstract::Vasculitides associated with anti-neutrophil cytoplasmic antibodies are heterogeneous, systemic, low prevalence and high morbidity and mortality entities. They include granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. In Latin America, there are few descripti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04631-3
更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to investigate musculoskeletal ultrasound (MSUS) as a diagnostic modality in DISH and to explore whether it might help in elucidating its pathogenesis and events that precede the calcification/ossification process. Fifty patients with DISH and 34 patients with osteoarthritis of the lower limb...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3190-0
更新日期:2015-03-01 00:00:00
abstract::A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04414-5
更新日期:2019-12-01 00:00:00
abstract::Our study was aimed to clarify an association between gastrointestinal (GI) amyloid-positive area and various kinds of factors including renal function in reactive amyloidosis associated with rheumatoid arthritis (RA). Twenty-five patients with an established diagnosis of reactive AA amyloidosis participated in the st...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1719-4
更新日期:2012-04-01 00:00:00
abstract::Pancreatitis is uncommon in systemic lupus erythematosus (SLE) and is rarely reported in children, possibly being related to macrophage activation syndrome (MAS). The incidence of MAS in children with lupus pancreatitis is unknown, as is their prognosis. In this case-based review, we report a pediatric patient with SL...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04388-4
更新日期:2020-05-01 00:00:00
abstract::To date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from th...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4026-0
更新日期:2018-08-01 00:00:00
abstract::Severe vaso-occlusive retinopathy is a relatively rare form of retinopathy in systemic lupus erythematosus (SLE). We report two patients with severe vaso-occlusive retinopathy in SLE who were treated with intravitreal bevacizumab (IVB). (Patient 1) A 35-year-old woman presented with left visual loss and was diagnosed ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2139-9
更新日期:2013-01-01 00:00:00
abstract::Agalactosyl IgG [Gal(0)] was first discovered in patients with rheumatoid arthritis (RA). However, the proportion of this glycoform is also raised in tuberculosis and leprosy. This has helped reinforce the suggestion that RA may be triggered by a mycobacterium-like slow bacterial infection. On the other hand, arthriti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00262090
更新日期:1995-01-01 00:00:00
abstract::Baseline and sequential liver biopsies were performed in ten patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) for more than 4 years. Liver biopsies were performed in all patients before the initiation of MTX therapy and were repeated after reaching a cumulative dose of 1500 mg or more. In four p...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00246875
更新日期:1992-01-01 00:00:00
abstract::E-selectin and intercellular adhesion molecule (ICAM)-1 are crucial to the inflammatory response in chronic inflammatory arthritis. Soluble (s) levels of these molecules in sera and synovial fluid (SF) correlate with some clinical parameters and synovial tissue expression of the same molecules in rheumatoid arthritis....
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0212-0
更新日期:2002-09-01 00:00:00
abstract::CD4(+) T cells from patients with systemic lupus erythematosus (SLE) exhibit increased expression of various proteins contributing to defective function of CD4(+) T cells. We evaluated the transcript and protein levels of perforin (PRF1) in CD4(+) T cells from SLE patients (n = 41) and healthy individuals (n = 34). Th...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1329-1
更新日期:2010-11-01 00:00:00
abstract::Rheumatoid arthritis is a systemic autoimmune disease resulting in joint destruction and deformities, but also associated with extraarticular and systemic manifestations. The later devastating conditions, such as the development of rheumatoid vasculitis, are more frequently encountered in seropositive patients and the...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3861-8
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3 mg/L). MA...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04571-y
更新日期:2020-09-01 00:00:00
abstract::Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to invest...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1557-4
更新日期:2011-02-01 00:00:00
abstract::Life expectancy in autoimmune rheumatic diseases (ARDs) remains lower compared to the general population, due to various comoborbidities. Cardiovascular disease (CVD) represents the main contributor to premature mortality. Conventional and biologic disease-modifying antirheumatic drugs (DMARDs) have considerably impro...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4004-6
更新日期:2018-06-01 00:00:00
abstract::Rickettsia rickettsii, a tick borne disease, is the pathogen responsible for inducing Rocky Mountain Spotted Fever (RMSF), an illness that can progress to fulminant multiorgan failure and death. We present a case where R. rickettsii, acquired on a camping trip, precipitated a flare of peripheral arthritis and episcler...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04330-8
更新日期:2019-09-01 00:00:00
abstract::The group of autoimmune cutaneous connective tissue diseases (CCTD) includes systemic sclerosis, dermatomyositis (DM), lupus erythematosus (LE), and subtypes. Most CCTD patients can be assigned to one of these phenotypes or mixed forms, and transitions among the subsets exist. We present the case of a 26-year-old woma...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0354-8
更新日期:2004-03-01 00:00:00
abstract::To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-4150-x
更新日期:2018-12-01 00:00:00
abstract::Osteoarthritis (OA) is a multifactorial degenerative pathology, whose progression is exacerbated by pro-inflammatory cytokines signaling. Among the changes triggered in chondrocytes during inflammation, modified expression of tiny epigenetic regulators as microRNAs was shown having deleterious implications for articul...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2754-8
更新日期:2014-05-01 00:00:00
abstract::Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2895-9
更新日期:2014-02-01 00:00:00
abstract::One hundred and eighteen unrelated Greek patients with classic rheumatoid arthritis (RA) were tissue-typed for HLA-A, -B, -DR antigens and the frequency was compared to that of healthy controls. Greek RA patients regardless of sex, anatomical severity, seropositivity and age at disease onset are not associated with an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541336
更新日期:1985-01-01 00:00:00
abstract::Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital betwe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2808-y
更新日期:2013-11-01 00:00:00
abstract::The purpose of this study was to determine the effects of an oral preparation containing hyaluronic acid on osteoarthritic knee joint pain and function as well as changes in inflammatory cytokines, bradykinin, and leptin. We also used heavy water to determine the turnover rates of glycosaminoglycans in synovial fluid....
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-014-3047-6
更新日期:2015-01-01 00:00:00