Abstract：
:Spondyloarthropathy refers to any joint disease of the vertebral column, but the term is mainly used for a specific group of disorders called seronegative spondyloarthropathies (SpAs). The axial skeletal involvement, peripheral and extra-articular manifestations and an association with the major histocompatibility complex class I human leukocyte antigen-B27 (HLA B27) are commonly shared features of SpAs. Klippel-Feil syndrome (KFS) is a rare congenital disorder characterized by the fusion of one or more cervical vertebrae, accompanied by various skeletal and extra-skeletal anomalies. We report a case of an adult male patient with HLA B27 positivity presenting with chronic cervical spine pain accompanied by morning stiffness and periodic night pain, with radiologically confirmed ankylosis and fusion of several cervical segments. His medical history included urogenital abnormalities operated in childhood and mild mitral prolapse. Initially suspected diagnosis of an early axial form of SpA was rejected after thorough workup. Instead, the nature of vertebral defects along with the past medical history of urogenital and cardiac abnormalities pointed towards the diagnosis of KFS. HLA B27 presence can be a confounder in patients presenting with spinal pain and that is why the differential diagnosis of CSD-s and SpA can be challenging in some patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Čota S,Žagar I,Delimar V,Pap M,Perić D,Perić Pdoi
10.1007/s00296-019-04346-0subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1655-1660issue
9eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-019-04346-0journal_volume
39pub_type
杂志文章,评审abstract：:Chronic inflammatory syndromes such as rheumatoid arthritis (RA) are associated with high frequencies of CD4+CD28- T cells. The number of these cells is genetically determined and may also be a consequence of chronic exposure to tumor necrosis factor-alpha (TNFalpha). The aim of this study was to examine whether the r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0374-4
更新日期：2004-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3545-9
更新日期：2016-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1364-y
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3589-x
更新日期：2017-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3460-0
更新日期：2016-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2541-y
更新日期：2013-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100132
更新日期：2001-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04784-1
更新日期：2021-01-27 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04602-8
更新日期：2020-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1407-4
更新日期：2011-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3330-1
更新日期：2016-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0491-6
更新日期：2008-05-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00286762
更新日期：1995-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0263-2
更新日期：2003-05-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2431-3
更新日期：2013-03-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1490-6
更新日期：2012-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 信件
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2080-y
更新日期：2012-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0947-y
更新日期：2009-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2701-8
更新日期：2013-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0948-x
更新日期：2010-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04588-3
更新日期：2020-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2124-3
更新日期：2012-11-01 00:00:00
