Abstract:
:The objective of this study was to search for proteomic patterns distinguishing patients with rheumatoid arthritis (RA) from healthy controls, biomarker candidates specific for early RA, and proteins reflecting disease activity, by profiling of serum proteins using magnetic bead-based (MB) separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Magnetic chemical affinity beads were used to differentially capture serum proteins prior to MALDI-TOF analysis. Seventy serum samples from patients with RA and 50 from healthy controls were analyzed. The samples were randomly allocated to the training set or test set to develop a pattern by means of decision tree algorithm. ANOVA test was utilized to search for biomarkers for early RA. Pearson correlation analysis was employed to estimate the overexpressed peaks in relation to Disease Activity Score (DAS)28. The algorithm identified a pattern based on 3 peaks (m/z 2,490, 5,910.07, 6,436.73) that, in the training set, separated patients with RA from healthy controls with a sensitivity and specificity of 87.5 and 96.7%, respectively. Blind test data indicated a sensitivity of 86.7% and specificity of 90%. The peaks of m/z 1,014.92 and 1,061.38 were raised significantly in early RA group (disease duration <12 months) compared with those in non-early RA group (disease duration ≥12 months) and healthy controls. A positive correlation was found between the intensity of peak 9,591.47 and DAS28 scores. Using MB separation followed by MALDI-TOF-MS enabled rapid diagnosis of RA according to fingerprint pattern, a method which might also help to assess disease activity and identify early RA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Long L,Li R,Li Y,Hu C,Li Zdoi
10.1007/s00296-010-1407-4subject
Has Abstractpub_date
2011-08-01 00:00:00pages
1069-74issue
8eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章abstract::A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-007-0381-y
更新日期:2007-11-01 00:00:00
abstract::The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F. ...
journal_title:Rheumatology international
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00296-018-4042-0
更新日期:2018-07-01 00:00:00
abstract::Osteoarthritis (OA) is a multifactorial degenerative pathology, whose progression is exacerbated by pro-inflammatory cytokines signaling. Among the changes triggered in chondrocytes during inflammation, modified expression of tiny epigenetic regulators as microRNAs was shown having deleterious implications for articul...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2754-8
更新日期:2014-05-01 00:00:00
abstract::The aim of this study was to evaluate the total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress index (OSI) in patients with postmenopausal osteoporosis. We also investigate the relation between bone mineral density and oxidative/antioxidative parameters. Thirty-nine patients with osteoporo...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0452-0
更新日期:2008-02-01 00:00:00
abstract::3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301776
更新日期:1995-01-01 00:00:00
abstract::Autoimmune diseases (AID) are caused by the loss of immunological tolerance against self-antigens. The deoxyribonuclease I (DNASE1) gene seems to participate in the genetic susceptibility of some AID. In fact, two mutations were reported among systemic lupus erythematosus (SLE) patients from Japan and Spain (the 172 A...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0917-4
更新日期:2009-11-01 00:00:00
abstract::The objective of the study was to assess the ESSDAI index characteristics in the SJÖGRENSER cohort (Spanish Rheumatology Association's registry of patients with Primary Sjögren Syndrome [PSS]). SJÖGRENSER is a prospective multicentric study on a cohort of Spanish patients with PSS who meet the 2002 American-European c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04285-w
更新日期:2019-06-01 00:00:00
abstract::Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1074-5
更新日期:2010-08-01 00:00:00
abstract::A community-based cohort comprising 150 patients with recent-onset seropositive arthritis or seronegative oligoarthritis or polyarthritis was monitored for 8 years. Of the different rheumatoid factor (RF) tests, the initial positivity in the most sensitive assays (latex slide test and IgM-RF by enzyme immunoassay) was...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541346
更新日期:1988-01-01 00:00:00
abstract::The aim of this study was to investigate the percentage of regulatory T cells and the correlation with clinical activity in Behçet's disease. Forty Behçet's disease (BD) patients, 18 males and 22 females, were included in the study. The patients were diagnosed according to the published BD criteria. Twenty age- and se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2835-8
更新日期:2013-12-01 00:00:00
abstract::A 45-year-old female presented to the rheumatology clinic with complaint of pain and swelling of multiple small joints of the hands and feet. She also complained of cough and shortness of breath onset around the same time. Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were posi...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-1294-8
更新日期:2011-12-01 00:00:00
abstract::Several studies of rheumatoid arthritis (RA) incidence and prevalence indicate that occurrence of the disease varies significantly among different populations. We aimed to estimate the prevalence and incidence of RA in South Korea. We used Korean National Health Insurance (NHI) claims data to estimate the prevalence o...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2590-2
更新日期:2013-06-01 00:00:00
abstract::We hypothesise that T-cell apoptosis and the percentage of T cells expressing molecules involved in apoptosis modulation (CD95, CD28) are altered at the inflammation site and in peripheral blood (PB) of children with juvenile idiopathic arthritis (JIA). Paired JIA samples of synovial fluid (SF) and PB ( n=7) and PB sa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0263-2
更新日期:2003-05-01 00:00:00
abstract::The aim of this study was to determine the association between individual and external exposure factors, and the reporting of Raynaud's phenomenon, with or without concomitant cold sensitivity. In a population-based nested case-control study, cases with Raynaud's phenomenon (N = 578), and matched controls (N = 1156), ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4133-y
更新日期:2019-02-01 00:00:00
abstract::To validate the Thai language version of the Psoriasis Epidemiology Screening Tool (PEST) and the Early Arthritis for Psoriatic Patients Questionnaire (EARP), as well as also to develop a new tool for screening psoriatic arthritis (PsA) among psoriasis (Ps) patients. This was a cross-sectional study. Ps patients visit...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3513-4
更新日期:2016-10-01 00:00:00
abstract::Activation of opioid receptors on peripheral sensory nerve terminals by opioid peptides that are produced and released from immune cells can result in inhibition of inflammatory pain. This study tests the hypothesis that postoperative pain is attenuated endogenously through a local sympathetic neurotransmitter-activat...
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-010-1489-z
更新日期:2011-10-01 00:00:00
abstract::The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1176-0
更新日期:2010-09-01 00:00:00
abstract::Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potenti...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04635-z
更新日期:2020-10-01 00:00:00
abstract::This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in patients with rheumatoid arthritis (RA) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (≥18 years) with a confirmed ...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-015-3312-3
更新日期:2015-11-01 00:00:00
abstract::Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2895-9
更新日期:2014-02-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) is a rare disease, and large epidemiological studies of this disease are limited. Furthermore, it has been difficult to show the incidence and characteristics of severe AOSD complications due to the rarity of this disease. The aim of our study was to describe the demographics of AOSD...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3546-8
更新日期:2016-10-01 00:00:00
abstract::The objective of this study is to investigate the endothelial function in complex regional pain syndrome. A total of 21 patients with CRPS and 15 healthy controls were enrolled. The mean age of patients was 22 +/- 4.9 years and the mean duration of the disease was 5.9 +/- 2.5 months. Flow-mediated vasodilatation (FMD)...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0451-1
更新日期:2008-02-01 00:00:00
abstract::Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3385-z
更新日期:2016-03-01 00:00:00
abstract::To investigate changes in the risk for serious infections (SIs) over time in Japanese rheumatoid arthritis (RA) patients treated with tumor necrosis factor inhibitors (TNFIs). This prospective cohort study included Japanese RA patients who began treatment with a TNFI from 2005 to 2007 (2005 group, n = 716, 634.2 patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-014-3045-8
更新日期:2014-12-01 00:00:00
abstract::We report three patients with rheumatoid arthritis (RA) who were treated with anti-TNF-α agents and who developed drug-induced lupus (DIL). Two of them received etanercept and the remainder adalimumab. We also present the favorable response observed with the withdrawal of the anti-TNF-alpha agents and the introduction...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2137-y
更新日期:2012-10-01 00:00:00
abstract::The aim of the study was to assess agreement between three-dimensional volumetric ultrasound (3D US) performed by inexperienced staff and real-time conventional ultrasound (2D US) performed by experienced rheumatologists in detecting and scoring rheumatoid arthritis (RA) lesions. Thirty-one RA patients underwent exami...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3606-0
更新日期:2017-02-01 00:00:00
abstract::The aim of this study was to analyze the characteristics of patients with diffuse connective tissue diseases (CTDs) complicated by pneumomediastinum and identify the risk factors associated with increased mortality in these patients. Twenty-eight patients with CTD-associated pneumomediastinum, who were admitted to our...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3046-7
更新日期:2014-12-01 00:00:00
abstract::Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1395-4
更新日期:2012-05-01 00:00:00
abstract::Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0006-2
更新日期:2006-03-01 00:00:00
abstract::Idiopathic granulomatous mastitis is an inflammatory mass in the breast. Patients typically present with a firm breast mass, often associated with inflammation of the overlying skin. Nipple retraction, peau d'orange-like changes, and axillary adenopathy may be present. We describe a 23-year-old pregnant woman with art...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1273-0
更新日期:2011-08-01 00:00:00