Abstract：
:Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity of systemic lupus erythematosus (SLE) in a Korean population. The study included 345 patients with SLE and 400 unrelated healthy controls. Genotyping for the -765G --> C polymorphism of COX-2 was performed by PCR-RFLP analysis. No difference in the distribution of the genotype frequencies between patients and controls was found. COX-2 genotypes were not associated with clinical features except hematologic abnormalities and anti-RNP antibody. We did not detect any association between COX-2 genotype and disease severity in SLE patients. These results suggest that the -765G --> C polymorphism of COX-2 does not play a significant role in the development of SLE in a Korean population. A possible protective effect of the low activity C allele against the production of anti-RNP antibodies merits further investigation.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Her MY,El-Sohemy A,Cornelis MC,Kim TH,Bae SCdoi
10.1007/s00296-006-0162-zsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
1-5issue
1eissn
0172-8172issn
1437-160Xjournal_volume
27pub_type
杂志文章abstract：:Postural changes are sometimes a risk factor for low back pain. Abnormal posture creates a strain on ligaments and muscles that indirectly affects the curvature of the lumbar spine. This study was planned to investigate the relationship between the angles of the lower lumbar spine and spinal mobility in acute and chro...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0268-x
更新日期：2003-07-01 00:00:00
abstract：:Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis associated with BRAFV600E mutations in more than 50% of cases and presenting with 95% with skeletal lesions. However, cutaneous, pulmonary, large vessels and central nervous system involvement can also occur. We report a case of a 25-year-old wo...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04627-z
更新日期：2020-09-01 00:00:00
abstract：:Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541284
更新日期：1986-01-01 00:00:00
abstract：:Previous studies have demonstrated an increased risk of breast cancer among patients with systemic sclerosis (scleroderma). To describe the clinical characteristics of 21 patients with both systemic sclerosis and breast cancer, and compare their risk factors to female scleroderma patients without breast cancer, in a p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0540-9
更新日期：2008-07-01 00:00:00
abstract：:We sought to determine the prevalence of additional connective tissue diseases (CTDs) in patients with idiopathic inflammatory myopathies (IIM), and to study the muscle biopsy patterns in various clinico-serologic subsets of myositis. We undertook a retrospective cohort study of 648 patients with a histological diagno...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04411-8
更新日期：2019-10-01 00:00:00
abstract：:Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0616-6
更新日期：2008-11-01 00:00:00
abstract：:Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive mediators via posttranslational carbamylation of proteins. As a new consequence of carbamylation, induction of anti-carbamylated autoantibodies were observed in rheumatoid arthritis (RA) patients, sometimes prior to onset of ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3472-9
更新日期：2016-06-01 00:00:00
abstract：:The aim of our study was to evaluate effectiveness of ultrasound treatment applied with exercise therapy in patients with ankylosing spondylitis. Fifty-two patients, who were diagnosed according to modified New York criteria, were aged 25-60, and have spine pain, were randomly assigned to two groups. Ultrasound (US) a...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-016-3441-3
更新日期：2016-05-01 00:00:00
abstract：:Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3864-5
更新日期：2018-05-01 00:00:00
abstract：:Ultrasound (US)-guided corticosteroid injection has been shown to be safe and effective for varied causes of plantar fasciitis; however, its use for Achilles tendinitis is controversial. We studied the efficacy and changes in US findings at Achilles enthesitis after corticosteroid injection in patients with spondyloar...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3440-4
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the adequacy of the following criteria for the classification of juvenile-onset spondyloarthropathies (JSpA): European Spondyloarthropathy Study Group criteria (ESSGCr) and Amor criteria (ACr) (proposed for adult SpA), Garmisch-Partenkirchen (G-PCr), seronegative enthe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0460-2
更新日期：2005-08-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3977-5
更新日期：2018-04-01 00:00:00
abstract：:Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04496-1
更新日期：2020-02-01 00:00:00
abstract：:The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of dis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0576-x
更新日期：2008-09-01 00:00:00
abstract：:31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00291145
更新日期：1991-01-01 00:00:00
abstract：:Recent data suggest that childhood and adulthood stressors may play a significant role in the development of an autoimmune disease. The present study explores the relationship between psoriatic arthritis (PsA) and positive and negative life events during childhood and adulthood in psoriatic patients. Forty-five patien...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2569-z
更新日期：2013-06-01 00:00:00
abstract：:Kawasaki disease (KD) is a systemic vasculitis that can involve the nervous system, including the cranial nerves. Central nervous system findings, especially irritability, lethargy, and aseptic meningitis, occur in 1-30 % of KD patients (1). Cranial nerve palsies are seen rarely, and abducens nerve palsy has been repo...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-016-3515-2
更新日期：2016-08-01 00:00:00
abstract：:The current clinical and laboratory parameters of Takayasu arteritis (TA) are insufficient for proper assessment of disease activity. The aims of this study were to investigate the markers of endothelial injury and repair, including circulating endothelial cell (CEC), circulating endothelial progenitor cell (CEPC) and...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2937-3
更新日期：2014-08-01 00:00:00
abstract：:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically s...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
更新日期：2016-01-01 00:00:00
abstract：:The Sjögren's syndrome A antigen (SS-A) purified by affinity chromatography from human spleen was shown to contain a major polypeptide with a mol. wt. of 55 000 daltons confirmed as SS-A by its reactivity with different anti-SS-A sera on affinity columns, immunodiffusion and the Western blot. A similar reactive polype...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541183
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Axillary lymph nodes (ALNs) are often seen on chest computed tomography (CT) in rheumatoid arthritis (RA) patients. Early reports described lymphadenopathy as one of the systemic manifestations rather than regional lymphadenopathy secondary to drainage from the affected joints. Subsequently, the importance o...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3992-6
更新日期：2018-06-01 00:00:00
abstract：:Osteoarthritis (OA) is a multifactorial degenerative pathology, whose progression is exacerbated by pro-inflammatory cytokines signaling. Among the changes triggered in chondrocytes during inflammation, modified expression of tiny epigenetic regulators as microRNAs was shown having deleterious implications for articul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2754-8
更新日期：2014-05-01 00:00:00
abstract：:When compared to general population, patients with rheumatoid arthritis are at higher risk of some malignancies (especially lymphomas and lung cancer). Genetic predisposition, chronic inflammatory stimuli and viral infections are some of the reasons untreated patients are at higher risk. Clinical studies and national/...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04706-1
更新日期：2021-02-01 00:00:00
abstract：:The cost-effectiveness of treatments that have the potential to change the "natural history" of a chronic progressive disease has to be evaluated over the long term. Cost-effectiveness estimates have been based on the concept that, with treatment, patients will not progress to the next level(s) of disease severity or ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1502-6
更新日期：2011-11-01 00:00:00
abstract：:Using different monoclonal antibodies, we performed an immunofluorescent technique on labial salivary glands in order to investigate the immunological phenomena involved in Sjögren's syndrome (SS). An aberrant expression of HLA-DR molecules was detected on cytoplasm of epithelial labial salivary cells in 9 out of 19 (...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00262708
更新日期：1995-01-01 00:00:00
abstract：:Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1954-3
更新日期：2012-06-01 00:00:00
abstract：:There are contradictory results in the relevant literature about the relationship between objective determinants of craniocervical posture and temporomandibular disorder (TMD), whereas no study has worked on ankylosing spondylitis (AS) and TMD relationship. We conducted this study to test the predictors of TMD in AS p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04563-y
更新日期：2020-06-01 00:00:00
abstract：:We have recently reported on two cases of scleroderma patients with ANCA-associated vasculitis for the first time in Korea. In order to explore the nature of this disease combination, we pooled together all the previously known cases and statistically analyzed them. Out of the 50 selected cases, survival analysis was ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-005-0011-5
更新日期：2006-03-01 00:00:00
abstract：:A total of 95 patients suffering from active rheumatoid arthritis were included in this double-blind, placebo-controlled study of the immunomodulator OM-8980. Treatment was one capsule daily of OM-8980 or placebo for 6 months. A significant improvement was observed in the OM-8980 group in comparison with the placebo g...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00270248
更新日期：1989-01-01 00:00:00
abstract：:Among the clinical manifestations of systemic lupus erythematosus is an arthropathy, which is usually non-erosive. In many cases, the joint involvement is mild. A subset of patients has deforming, non-erosive Jaccoud's arthropathy, and a minority have an arthropathy with clinical findings similar to rheumatoid arthrit...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-008-0780-8
更新日期：2009-08-01 00:00:00
