Abstract：
:Low-dose radiotherapy (LD-RT) has been widely used for treatment of non-malignant disorders since its introduction and animal studies show anti-inflammatory effects in osteoarthritis (OA). However, the evidence for its effect in clinical practice remains unclear. Therefore, the aim of this study is to systematically summarise the literature on effectiveness of LD-RT on pain and functioning in patients with OA and its safety. Broad search terms were used to search PubMed, EMBASE and Web of Science. Primary inclusion criteria were osteoarthritis as indication, radiotherapy as intervention, written in English, German or Dutch and published since 1980. Study quality was assessed using the EPHPP Quality Assessment Tool for Quantitative Studies (scale: strong, moderate, weak). Seven studies were suitable for inclusion, all with retrospective uncontrolled observational design. Methodological quality of all studies was judged as weak. Most studies used 2-3 RT sessions per week for 2 weeks, some with booster session after 6 weeks. Generally, non-validated single-item measurement instruments were used to evaluate the effect of LD-RT on pain and function. Across the studies, in 25-90 and 29-71 % of the patients pain and functioning improved, respectively. Side effects were described in one study, none were reported. Our results show that there is insufficient evidence for efficacy or to confirm the safety of LD-RT in treatment of OA, due to absence of high-quality studies. Therefore, a well-designed, sham-controlled and blinded randomised trial, using validated outcome measures is warranted to demonstrate the value of LD-RT for OA in clinical practice.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Minten MJ,Mahler E,den Broeder AA,Leer JW,van den Ende CHdoi
10.1007/s00296-015-3337-7subject
Has Abstractpub_date
2016-01-01 00:00:00pages
133-42issue
1eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-015-3337-7journal_volume
36pub_type
杂志文章,评审abstract：:Low back pain is considered a problem with multiple facets for which the underlying causative factors should be determined. The aim of this study was to evaluate the relationships between depression, clinical status, and radiographic findings in a group of fifty patients with low back pain for more than 6 months. The ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100133
更新日期：2001-10-01 00:00:00
abstract：:We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0522-5
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journal_title：Rheumatology international
pub_type： 历史文章,杂志文章
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更新日期：2012-10-01 00:00:00
abstract：:Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1954-3
更新日期：2012-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0227-z
更新日期：2007-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3419-6
更新日期：2016-05-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541219
更新日期：1981-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0391-3
更新日期：2004-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,已发布勘误
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更新日期：2018-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2812-2
更新日期：2013-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4056-7
更新日期：2018-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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更新日期：2019-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3358-2
更新日期：2016-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541361
更新日期：1984-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-010-1427-0
更新日期：2011-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1502-6
更新日期：2011-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541144
更新日期：1983-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2701-8
更新日期：2013-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0358-4
更新日期：2004-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0818-y
更新日期：2009-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00307733
更新日期：1993-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00246875
更新日期：1992-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0844-4
更新日期：2009-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0107-6
更新日期：2006-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1715-8
更新日期：2013-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3517-0
更新日期：2016-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3507-2
更新日期：2016-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1329-1
更新日期：2010-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0538-x
更新日期：2005-08-01 00:00:00
abstract：:Rheumatoid arthritis is a progressive autoimmune disease characterised by severely swollen and painful joints. To compliment pharmacotherapy, people living with rheumatoid arthritis often turn to dietary interventions such as the Mediterranean diet. The aim of the present systematic review is to discuss the effects of...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3912-1
更新日期：2018-05-01 00:00:00
