Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.

Abstract:

:We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA). The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar spine or pelvis. After discontinuation of the treatment, gradual decline of bone mineral density at lumbar and femoral sites was detected with serial DEXA measurements. To the best of our knowledge, although various abnormalities of bone due to retinoids have been described before, reversible sclerotic changes have not been reported.

journal_name

Rheumatol Int

authors

Atalay A,Altaykan A,Ergin G,Kutsal YG

doi

10.1007/s00296-003-0391-3

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

297-300

issue

5

eissn

0172-8172

issn

1437-160X

journal_volume

24

pub_type

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