Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis.

Abstract:

:Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acute local synovitis (n = 10) was observed. In contrast, SF IL-6 was positively correlated with histological characteristics of chronic synovitis (n = 10; P < or = 0.01) and elevated plasma IgG concentrations (n = 15; P < or = 0.05). In vitro concentrations of IL-6 comparable to those detected in SF increased the production of both IgG and IgM by synovial membrane mononuclear cells. The present results contribute to the view that high local IL-6 concentrations in SF promote chronic synovitis in RA.

journal_name

Rheumatol Int

authors

Sack U,Kinne RW,Marx T,Heppt P,Bender S,Emmrich F

doi

10.1007/BF00307733

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

45-51

issue

2

eissn

0172-8172

issn

1437-160X

journal_volume

13

pub_type

杂志文章
  • Matrix metalloproteinase genes on chromosome 11q22 and risk of carpal tunnel syndrome.

    abstract::Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-015-3385-z

    authors: Burger MC,De Wet H,Collins M

    更新日期:2016-03-01 00:00:00

  • Abducens nerve palsy in a girl with incomplete Kawasaki disease.

    abstract::Kawasaki disease (KD) is a systemic vasculitis that can involve the nervous system, including the cranial nerves. Central nervous system findings, especially irritability, lethargy, and aseptic meningitis, occur in 1-30 % of KD patients (1). Cranial nerve palsies are seen rarely, and abducens nerve palsy has been repo...

    journal_title:Rheumatology international

    pub_type: 信件

    doi:10.1007/s00296-016-3515-2

    authors: Emiroglu M,Alkan G,Kartal A,Cimen D

    更新日期:2016-08-01 00:00:00

  • Prevalence of systemic lupus erythematosus and risk factors in rural areas of Anhui Province.

    abstract::Systemic lupus erythematosus (SLE) is a severe complex rheumatic disease, but good estimate of its prevalence and risk factors is lacking in China. The aim of the study was to explore the prevalence of SLE and risk factors in rural areas of Anhui Province of China. Eleven counties were randomly selected in Anhui Provi...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-013-2902-1

    authors: Zou YF,Feng CC,Zhu JM,Tao JH,Chen GM,Ye QL,Cen H,Leng RX,Pan FM,Pan HF,Li R,Fan YG,Wang B,Li XP,Zhang FY,Ye DQ

    更新日期:2014-03-01 00:00:00

  • Prevalence of comorbidities in Mexican mestizo patients with rheumatoid arthritis.

    abstract::Patients with rheumatoid arthritis (RA) have a high risk for comorbid conditions which increase mortality, hospital admissions, costs of care and inability. To evaluate the prevalence of comorbidities in Mexican mestizo patients with RA and determine the associated risk factors. Cross-sectional study in which RA patie...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-017-3769-3

    authors: Galarza-Delgado DA,Azpiri-Lopez JR,Colunga-Pedraza IJ,Cárdenas-de la Garza JA,Vera-Pineda R,Wah-Suárez M,Arvizu-Rivera RI,Martínez-Moreno A,Ramos-Cázares RE,Torres-Quintanilla FJ,Valdovinos-Bañuelos A,Esquivel-Valerio JA,Garza-El

    更新日期:2017-09-01 00:00:00

  • Behçet's disease: immunological relevance with arthritis of ankylosing spondylitis.

    abstract::Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 a...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2446-9

    authors: Aktas Cetin E,Cosan F,Kucuksezer UC,Bilgic S,Cagatay Y,Gul A,Deniz G

    更新日期:2013-03-01 00:00:00

  • Experimental immune mediated arthritis in rhesus monkeys. A model for human rheumatoid arthritis?

    abstract::The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen ind...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF02274777

    authors: Bakker NP,van Erck MG,Zurcher C,Faaber P,Lemmens A,Hazenberg M,Bontrop RE,Jonker M

    更新日期:1990-01-01 00:00:00

  • The value of cartilage biomarkers in progressive knee osteoarthritis: cross-sectional and 6-year follow-up study in middle-aged subjects.

    abstract::To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2463-8

    authors: Kumm J,Tamm A,Lintrop M,Tamm A

    更新日期:2013-04-01 00:00:00

  • Three saints with deformed extremities in an Italian Renaissance altarpiece.

    abstract::A fifteenth-century Florentine altarpiece painted by the Pollaiuolo brothers, Antonio (1433-1498) and Piero (1443-1496), shows three saints with evident deformities of the hands and feet. The pathologies concerned are tentatively identified, and various rationales for their presence in the painting are discussed. Of p...

    journal_title:Rheumatology international

    pub_type: 历史文章,杂志文章

    doi:10.1007/s00296-016-3599-8

    authors: Albury WR,Weisz GM

    更新日期:2017-03-01 00:00:00

  • Tocilizumab treatment in Felty's syndrome.

    abstract::Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side ef...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-020-04588-3

    authors: Li R,Wan Q,Chen P,Mao S,Wang Q,Li X,Yang Y,Dong L

    更新日期:2020-07-01 00:00:00

  • Survival analysis and risk factors for mortality in connective tissue disease-associated pneumomediastinum.

    abstract::The aim of this study was to analyze the characteristics of patients with diffuse connective tissue diseases (CTDs) complicated by pneumomediastinum and identify the risk factors associated with increased mortality in these patients. Twenty-eight patients with CTD-associated pneumomediastinum, who were admitted to our...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-3046-7

    authors: Zhang L,Shen M,Zhang F,Tang F

    更新日期:2014-12-01 00:00:00

  • Bisphosphonate-related osteonecrosis of the jaw in non-malignant bone disease.

    abstract::Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with dela...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-013-2771-7

    authors: Wong PK,Borromeo GL,Wark JD

    更新日期:2013-09-01 00:00:00

  • Acute psycosis in systemic lupus erythematosus.

    abstract::Psychiatric manifestations are common in systemic lupus erythematosus (SLE) and often represent a challenging diagnostic and therapeutic problem, mainly because the uncertainties of the pathogenic mechanisms. We report a case of acute psychosis occurring in a female with SLE due to the stress of having a severe diseas...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-007-0479-2

    authors: Marasini B,Massarotti M

    更新日期:2008-02-01 00:00:00

  • Effects of leflunomide and methotrexate in rheumatoid arthritis detected by digital X-ray radiogrammetry and computer-aided joint space analysis.

    abstract::The aim of the present study was to evaluate the effect of long-term leflunomide and methotrexate (MTX) therapy during the course of rheumatoid arthritis (RA) estimated by digital X-ray radiogrammetry (DXR) and computer-aided joint space analysis (CAJSA) as diagnostic tools for the quantification of disease-related pe...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-008-0682-9

    authors: Pfeil A,Lippold J,Eidner T,Lehmann G,Oelzner P,Renz DM,Hansch A,Wolf G,Hein G,Kaiser WA,Böttcher J

    更新日期:2009-01-01 00:00:00

  • Biological therapies for the treatment of Behçet's disease-related uveitis beyond TNF-alpha blockade: a narrative review.

    abstract::Intraocular inflammation is one of the more relevant complications of Behçet's disease (BD), which tends to respond poorly to different medications. The ocular histopathologic changes are basically identical to those occurring in other organs and consist in a necrotizing leukocytoclastic obliterative vasculitis, which...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-017-3775-5

    authors: Sota J,Rigante D,Lopalco G,Frediani B,Franceschini R,Galeazzi M,Iannone F,Tosi GM,Fabiani C,Cantarini L

    更新日期:2018-01-01 00:00:00

  • Seronegative Lyme arthritis.

    abstract::We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synov...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-007-0333-6

    authors: Holl-Wieden A,Suerbaum S,Girschick HJ

    更新日期:2007-09-01 00:00:00

  • Rheumatoid arthritis and Proteus: a possible aetiological association.

    abstract::The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorga...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/BF00271885

    authors: Ebringer A,Khalafpour S,Wilson C

    更新日期:1989-01-01 00:00:00

  • Does weather affect daily pain intensity levels in patients with acute low back pain? A prospective cohort study.

    abstract::The aim of this study was to investigate the influence of various weather parameters on pain intensity levels in patients with acute low back pain (LBP). We performed a secondary analysis using data from the PACE trial that evaluated paracetamol (acetaminophen) in the treatment of acute LBP. Data on 1604 patients with...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-015-3419-6

    authors: Duong V,Maher CG,Steffens D,Li Q,Hancock MJ

    更新日期:2016-05-01 00:00:00

  • The Czech version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR).

    abstract::The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report results of the cross-cultural adaptation and validation of the parent and patient v...

    journal_title:Rheumatology international

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00296-018-3969-5

    authors: Doležalová P,Bohm M,Linková L,Saifrídová M,Němcová D,Dallos T,Consolaro A,Bovis F,Ruperto N,Paediatric Rheumatology International Trials Organisation (PRINTO).

    更新日期:2018-04-01 00:00:00

  • Developing the Thai Siriraj Psoriatic Arthritis Screening Tool and validating the Thai Psoriasis Epidemiology Screening Tool and the Early Arthritis for Psoriatic Patients questionnaire.

    abstract::To validate the Thai language version of the Psoriasis Epidemiology Screening Tool (PEST) and the Early Arthritis for Psoriatic Patients Questionnaire (EARP), as well as also to develop a new tool for screening psoriatic arthritis (PsA) among psoriasis (Ps) patients. This was a cross-sectional study. Ps patients visit...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-016-3513-4

    authors: Chiowchanwisawakit P,Wattanamongkolsil L,Srinonprasert V,Petcharat C,Siriwanarangsun P,Katchamart W

    更新日期:2016-10-01 00:00:00

  • Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study.

    abstract::Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to invest...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1557-4

    authors: Dimitroulas T,Giannakoulas G,Dimitroula H,Sfetsios T,Parcharidou D,Karvounis H,Settas L

    更新日期:2011-02-01 00:00:00

  • Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

    abstract::Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2493-2

    authors: Baker DA,Eudaly J,Smith CD,Obeid LM,Gilkeson GS

    更新日期:2013-10-01 00:00:00

  • Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis.

    abstract::The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was det...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-016-3495-2

    authors: Khanzadeh A,Habibagahi Z,Hosseini A,Amirghofran Z

    更新日期:2016-08-01 00:00:00

  • Celiac disease of the joint.

    abstract::A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1670-4

    authors: Ozyemisci-Taskiran O,Cengiz M,Atalay F

    更新日期:2011-05-01 00:00:00

  • Anti-dsDNA: choice of assay in relation to clinical value.

    abstract::Antibodies to DNA are quite specific for systemic lupus erythematosus (SLE) and occur in the majority of SLE patients. Therefore, their detection is an important diagnostic aid to the clinician. Detection of anti-dsDNA may precede the diagnosis of SLE by more than a year. Fluctuations in the level of anti-dsDNA in an ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/BF00304496

    authors: Smeenk RJ,van den Brink HG,Brinkman K,Termaat RM,Berden JH,Swaak AJ

    更新日期:1991-01-01 00:00:00

  • Disseminated multiple ostial stenoses in a young woman presenting as unstable angina.

    abstract::A previously healthy 40-year-old woman presented as unstable angina. She had a family history of stroke as the only cardiovascular risk factor. Her blood pressure on admission was 150/90 mmHg. Laboratory study showed absolutely all negative markers of inflammation, autoimmune disorders, or atherosclerosis. Coronary an...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-008-0739-9

    authors: Lee SH,Chae JK,Lim ST,Ko JK

    更新日期:2009-04-01 00:00:00

  • Is psychological distress intrinsic to fibromyalgia syndrome? Cross-sectional analysis in two clinical presentations.

    abstract::Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2199-x

    authors: Salgueiro M,Aira Z,Buesa I,Bilbao J,Azkue JJ

    更新日期:2012-11-01 00:00:00

  • Cytokine enhancement of monocyte/synovial cell attachment to the surface of cartilage: a possible trigger of pannus formation in arthritis.

    abstract::When rheumatoid articular cartilage samples were incubated with normal peripheral blood monocytes and cultured synovial cells in the presence of recombinant human interleukin-1 (IL-1) in vitro, large numbers of monocytes were seen to be attached to the articular surface. Significant numbers of monocytes invaded the ca...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00290248

    authors: Ishikawa H,Ohno O,Saura R,Matsubara T,Kuroda T,Hirohata K

    更新日期:1991-01-01 00:00:00

  • Lower extremity lipedema, upper extremity lipodystrophy and severe calcinosis complicating juvenile dermatomyositis.

    abstract::Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and calcinosis. Recently, new clinical findings, such as lipodystrophy accompanied with increased fat de...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-014-3031-1

    authors: Pavlov-Dolijanovic SR,Vujasinovic Stupar NZ,Gavrilov N,Seric S

    更新日期:2014-11-01 00:00:00

  • Addison's disease secondary to connective tissue diseases: a report of six cases.

    abstract::Addison's disease is an autoimmune process. However, Addison's disease associated with connective tissue diseases (CTD) is only occasionally reported. Here, we report six cases of Addison's disease secondary to a variety of CTD, which include systemic lupus erythematosus, Takayasu arteritis, systemic sclerosis, ankylo...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-008-0749-7

    authors: Zhang ZL,Wang Y,Zhou W,Hao YJ

    更新日期:2009-04-01 00:00:00

  • Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality?

    abstract::We describe the case of a 59 year old man with systemic sclerosis and superficial siderosis of the central nervous system characterized by progressive worsening of walking with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia. Ferritin and oligoclonal bands were found on lumbar ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-008-0523-x

    authors: Simeoni S,Puccetti A,Tinazzi E,Tomelleri G,Corrocher R,Lunardi C

    更新日期:2008-06-01 00:00:00