Abstract:
:Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acute local synovitis (n = 10) was observed. In contrast, SF IL-6 was positively correlated with histological characteristics of chronic synovitis (n = 10; P < or = 0.01) and elevated plasma IgG concentrations (n = 15; P < or = 0.05). In vitro concentrations of IL-6 comparable to those detected in SF increased the production of both IgG and IgM by synovial membrane mononuclear cells. The present results contribute to the view that high local IL-6 concentrations in SF promote chronic synovitis in RA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Sack U,Kinne RW,Marx T,Heppt P,Bender S,Emmrich Fdoi
10.1007/BF00307733subject
Has Abstractpub_date
1993-01-01 00:00:00pages
45-51issue
2eissn
0172-8172issn
1437-160Xjournal_volume
13pub_type
杂志文章abstract::Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3385-z
更新日期:2016-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 信件
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更新日期:2016-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2902-1
更新日期:2014-03-01 00:00:00
abstract::Patients with rheumatoid arthritis (RA) have a high risk for comorbid conditions which increase mortality, hospital admissions, costs of care and inability. To evaluate the prevalence of comorbidities in Mexican mestizo patients with RA and determine the associated risk factors. Cross-sectional study in which RA patie...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3769-3
更新日期:2017-09-01 00:00:00
abstract::Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2446-9
更新日期:2013-03-01 00:00:00
abstract::The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen ind...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274777
更新日期:1990-01-01 00:00:00
abstract::To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...
journal_title:Rheumatology international
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更新日期:2013-04-01 00:00:00
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journal_title:Rheumatology international
pub_type: 历史文章,杂志文章
doi:10.1007/s00296-016-3599-8
更新日期:2017-03-01 00:00:00
abstract::Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side ef...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3046-7
更新日期:2014-12-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-013-2771-7
更新日期:2013-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0479-2
更新日期:2008-02-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0682-9
更新日期:2009-01-01 00:00:00
abstract::Intraocular inflammation is one of the more relevant complications of Behçet's disease (BD), which tends to respond poorly to different medications. The ocular histopathologic changes are basically identical to those occurring in other organs and consist in a necrotizing leukocytoclastic obliterative vasculitis, which...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3775-5
更新日期:2018-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0333-6
更新日期:2007-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00271885
更新日期:1989-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3419-6
更新日期:2016-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-3969-5
更新日期:2018-04-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3513-4
更新日期:2016-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3495-2
更新日期:2016-08-01 00:00:00
abstract::A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1670-4
更新日期:2011-05-01 00:00:00
abstract::Antibodies to DNA are quite specific for systemic lupus erythematosus (SLE) and occur in the majority of SLE patients. Therefore, their detection is an important diagnostic aid to the clinician. Detection of anti-dsDNA may precede the diagnosis of SLE by more than a year. Fluctuations in the level of anti-dsDNA in an ...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00304496
更新日期:1991-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0739-9
更新日期:2009-04-01 00:00:00
abstract::Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2199-x
更新日期:2012-11-01 00:00:00
abstract::When rheumatoid articular cartilage samples were incubated with normal peripheral blood monocytes and cultured synovial cells in the presence of recombinant human interleukin-1 (IL-1) in vitro, large numbers of monocytes were seen to be attached to the articular surface. Significant numbers of monocytes invaded the ca...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00290248
更新日期:1991-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3031-1
更新日期:2014-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0749-7
更新日期:2009-04-01 00:00:00
abstract::We describe the case of a 59 year old man with systemic sclerosis and superficial siderosis of the central nervous system characterized by progressive worsening of walking with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia. Ferritin and oligoclonal bands were found on lumbar ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0523-x
更新日期:2008-06-01 00:00:00