Rheumatoid arthritis and Proteus: a possible aetiological association.

Abstract:

:The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorganisms, thereby suggesting some molecular similarity or cross-reactivity between bacteria and HLA antigens. The concept is proposed that Proteus-reactive arthritis occurs during active phases of RA and tissue damage is mediated through immunological activity involving HLA antigens.

journal_name

Rheumatol Int

authors

Ebringer A,Khalafpour S,Wilson C

doi

10.1007/BF00271885

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

223-8

issue

3-5

eissn

0172-8172

issn

1437-160X

journal_volume

9

pub_type

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