Abstract:
:IL-17 has a role in inflammation in RA, and its levels in joints correlate with disease severity. Multiple RCTs have been performed to study effects of anti-IL-17 agents. The objective of this study was to perform a systematic review and meta-analysis to analyze the efficacy and safety of anti-IL-17 agents in the management of RA. This work is based on a systematic review of studies retrieved by a sensitive search strategy in PubMed, EMBASE and Cochrane CENTRAL from inception through 9/7/15. Study selection criteria were the following: adult patients (age ≥ 18 years) with RAs, random selection of patients for anti-IL-17 therapy and treatment response compared to placebo. We performed systematic literature review per PRISMA guideline and two investigators independently selected seven randomized clinical trials (RCTs) for meta-analysis. We used random effect model calculating odds ratio (OR) and 95 % confidence interval (CI) to measure the efficacy with ACR20/50/70 responses and the safety with adverse events. Seven studies with total of 1226 patients including 905 in anti-IL-17 group and 321 in placebo were included in the meta-analysis. Anti-IL-17 was effective in achieving ACR20 and ACR50 compared to placebo (OR 2.47, 95 % CI 1.29-4.72, P = 0.006, I (2) 77 % and OR 2.94, 95 % CI 1.37-6.28, P = 0.005, I (2) 64 %, respectively). Data analysis for ACR70 showed a favorable trend toward anti-IL-17 (OR 2.62, 95 % CI 1-6.89, P = 0.05, I (2) 15 %). Subgroup analysis of ACR20 for individual anti-IL-17 agents showed that ixekizumab was more effective than placebo, while secukinumab showed a trend toward achieving the ACR20 response. However, brodalumab was not effective compared to placebo. Safety analysis did not show increased risk of any or serious adverse effects by anti-IL-17 compared to placebo (OR 1.23, 95 % CI 0.94-1.61, P = 0.13, I (2) = 0 % and OR 1.28, 95 % CI 0.57-2.88, P = 0.55, I (2) = 0 %, respectively). This meta-analysis concludes that anti-IL-17 is effective in the treatment of RA without increased risk of any or serious adverse effects; however, the results are limited by significant heterogeneity and small duration of studies.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kunwar S,Dahal K,Sharma Sdoi
10.1007/s00296-016-3480-9subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1065-75issue
8eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-016-3480-9journal_volume
36pub_type
杂志文章,meta分析,评审abstract::We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3618-9
更新日期:2017-01-01 00:00:00
abstract::The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (-160°C) and cold air (-30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the app...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-011-2078-5
更新日期:2012-10-01 00:00:00
abstract::Patients with rheumatoid arthritis (RA) have a high risk for comorbid conditions which increase mortality, hospital admissions, costs of care and inability. To evaluate the prevalence of comorbidities in Mexican mestizo patients with RA and determine the associated risk factors. Cross-sectional study in which RA patie...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3769-3
更新日期:2017-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) patients have high risk for anxiety and depression. We aimed to investigate the prevalence and risk factors of anxiety and depression in SLE patients in Southwest China. Participants were recruited by convenience sampling from Rheumatic Outpatient Clinic of West China Hospital Sichua...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3559-3
更新日期:2016-12-01 00:00:00
abstract::The objective of the study is to investigate the clinical characteristics and long-term prognosis including flares and organ damage in patients with giant cell arteritis (GCA) from a tertiary referral centre and compare these features in different subgroups. In this retrospective observational study, patients with GCA...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04730-1
更新日期:2021-02-01 00:00:00
abstract::A previously healthy 40-year-old woman presented as unstable angina. She had a family history of stroke as the only cardiovascular risk factor. Her blood pressure on admission was 150/90 mmHg. Laboratory study showed absolutely all negative markers of inflammation, autoimmune disorders, or atherosclerosis. Coronary an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0739-9
更新日期:2009-04-01 00:00:00
abstract::Thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP) is a rare but potentially lethal condition requiring rapid recognition, diagnosis, and initiation of therapy. We experienced a case of a 61-year-old woman with primary Sjögren's syndrome (pSS) complicated with severe renal TMA/TTP following IgM...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1569-0
更新日期:2013-01-01 00:00:00
abstract:KEY MESSAGES:There is a relative lack of confidence among GPs in the assessment and management of IBP vs. mechanical back pain. A simple screening tool for SpA, applicable in primary care urgently needs to be developed. It is reasonable for patients with symptoms suggestive of inflammatory back pain to be referred to s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4058-5
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0556-8
更新日期:2006-01-01 00:00:00
abstract::A 45-year-old female presented to the rheumatology clinic with complaint of pain and swelling of multiple small joints of the hands and feet. She also complained of cough and shortness of breath onset around the same time. Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were posi...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-1294-8
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:X-ray is the fundamental imaging technique in both diagnosis and follow-up of rheumatic diseases. As patients often require sequential X-rays over many years, dose reduction is of great importance. New advanced noise reduction algorithms allow for a dose reduction of up to 50%. The aim of this study was to e...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04560-1
更新日期:2020-06-01 00:00:00
abstract::Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960100132
更新日期:2001-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a severe complex rheumatic disease, but good estimate of its prevalence and risk factors is lacking in China. The aim of the study was to explore the prevalence of SLE and risk factors in rural areas of Anhui Province of China. Eleven counties were randomly selected in Anhui Provi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2902-1
更新日期:2014-03-01 00:00:00
abstract::Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274840
更新日期:1990-01-01 00:00:00
abstract::Abnormal manifestations of central nervous system in system lupus erythematosus (SLE) patients are mainly caused by primary neuropsychiatric SLE (NP-SLE). We reported a new onset SLE patient who had secondary neuropsychiatric manifestations caused by Epstein-Barr virus (EBV) encephalitis. Although EBV has an uncertain...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1877-z
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04724-z
更新日期:2021-01-01 00:00:00
abstract::Accumulating evidence suggests that defects in the function of CD4(+)CD25(+) regulatory T cells (Tregs) are important in immune-mediated diseases such as rheumatoid arthritis. Here, we investigated the effects of various disease-modifying anti-rheumatic drugs (DMARDs) on Treg function. Tregs and CD4(+)CD25(-) effector...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2365-9
更新日期:2013-02-01 00:00:00
abstract::The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541245
更新日期:1982-01-01 00:00:00
abstract::Antibodies to citrullinated proteins and rheumatoid factor (RF) are widely used in patients with rheumatoid arthritis (RA) and the antibodies to citrullinated proteins appear to be the most specific markers of the disease. The objective was to compare the diagnostic performance of the anti-cyclic citrullinated peptide...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0980-x
更新日期:2010-02-01 00:00:00
abstract::Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and vasculopathy. A key feature is the presence of T cells in inflammatory lesions. To establish the differences in peripheral blood T helper (Th) subpopulations in diffuse cutaneous (dc) and limited cutaneous (lc) SSc patients, blood samples ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2056-y
更新日期:2012-09-01 00:00:00
abstract::We aimed to evaluate the cost-effectiveness of certolizumab pegol (CZP), a pegylated fc-free anti-TNF, as add-on therapy to methotrexate (MTX) versus etanercept, adalimumab, or golimumab in patients with moderate-to-severe active rheumatoid arthritis (RA) not responding to the conventional synthetic disease-modifying ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3736-z
更新日期:2017-09-01 00:00:00
abstract::Antibodies to DNA are quite specific for systemic lupus erythematosus (SLE) and occur in the majority of SLE patients. Therefore, their detection is an important diagnostic aid to the clinician. Detection of anti-dsDNA may precede the diagnosis of SLE by more than a year. Fluctuations in the level of anti-dsDNA in an ...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00304496
更新日期:1991-01-01 00:00:00
abstract::Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4102-5
更新日期:2018-09-01 00:00:00
abstract::Radiation synovectomy (RS) is one of many therapeutic options used for recurrent joint synovitis. Our aim was to analyze the effect of the surgical synovectomy combined with yttrium 90 ((90)Y) in the treatment for recurrent joint synovitis. A surgical combined RS procedure was used on 32 knees of 30 patients. They wer...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2540-z
更新日期:2013-05-01 00:00:00
abstract::Leg ulcers are a manifestation of antiphospholipid syndrome (APS), and characteristically respond poorly to treatment. Because the similar findings both clinical and pathological to pyoderma gangrenosum (PG), we treated these patients with a combination of immunosuppression (steroids, azathioprine or cyclosporine), ac...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1418-1
更新日期:2010-07-01 00:00:00
abstract::Reported here is a 19-year-old female patient with familial Mediterranean fever who was seen for altered mental status and seizures. She was eventually diagnosed to have posterior reversible leukoencephalopathy syndrome. Although a variety of conditions have been reported in association with this syndrome, to our best...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1388-3
更新日期:2012-06-01 00:00:00
abstract::Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541164
更新日期:1982-01-01 00:00:00
abstract::Previous studies have demonstrated an increased risk of breast cancer among patients with systemic sclerosis (scleroderma). To describe the clinical characteristics of 21 patients with both systemic sclerosis and breast cancer, and compare their risk factors to female scleroderma patients without breast cancer, in a p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0540-9
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:We aimed to assess the clinical significance of Krebs von den Lungen-6 (KL-6) in the diagnosis and severity of interstitial lung disease (ILD) in a French cohort of patients with systemic sclerosis (SSc). METHODS:Serum KL-6 concentrations were measured with chemiluminescent enzyme immunoassay (CLEIA) in 75 ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3987-3
更新日期:2018-05-01 00:00:00
abstract::To investigate the expression and effect of farnesoid X receptor (FXR) on systemic lupus erythematosus (SLE) liver dysfunction and indicate its hepatoprotective role and the immunomodulatory property. mRNA and protein levels of FXR were determined on the liver specimens of SLE patients with liver injury as well as MRL...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1874-2
更新日期:2012-06-01 00:00:00