Abstract:
:We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clinical examination, serological tests, pulmonary function testing, 24-h Holter monitoring and complete two-dimensional echocardiography including strain analysis. The parameters of LV structure (interventricular septum thickness and LV mass index) and RV structure (RV wall thickness) were significantly higher in SSc patients. LV and RV diastolic function (estimated by mitral and tricuspid E/e' ratio) was significantly impaired in SSc group comparing with the healthy controls. LV and RV longitudinal function was significantly deteriorated in SSc patients. LV circumferential strain was also significantly lower in SSc group, whereas LV radial strain was similar between the observed groups. All parameters of time and frequency domain of HRV were decreased in SSc patients. LV and RV cardiac remodeling parameters, particularly diastolic function and longitudinal strain, were associated with HRV indices without regard to the main demographic or the clinical and echocardiographic characteristics. Rodnan Skin Score was also independently associated with biventricular cardiac remodeling in SSc patients. LV and RV structure, function and mechanics, as well as autonomic nervous function, were significantly impaired in SSc patients. There is the significant association between biventricular cardiac remodeling and autonomic function in these patients, which could be useful for their everyday clinical assessment.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Zlatanovic M,Tadic M,Celic V,Ivanovic B,Stevanovic A,Damjanov Ndoi
10.1007/s00296-016-3618-9subject
Has Abstractpub_date
2017-01-01 00:00:00pages
49-57issue
1eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-016-3618-9journal_volume
37pub_type
杂志文章abstract::Echocardiographic examination and 24-h electrocardiographic Holter monitoring were carried out on 35 patients with nodular rheumatoid arthritis (RA) and 35 with non-nodular RA, who were matched with the nodular RA group regarding age, sex and BSA. A further 35 patients with osteoarthrosis and spondyloarthrosis matched...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050079
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abstract::To investigate the effects of TNF-alpha -308, -238 promoter polymorphisms on TNF-alpha transcription in B27 positive Chinese patients with ankylosing spondylitis (AS). The possible relationship between polymorphisms, MHC antigens, and quantitative TNF-alpha mRNA expression were evaluated. Single nucleotide polymorphis...
journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04609-1
更新日期:2020-11-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0194-y
更新日期:2002-06-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00290299
更新日期:1993-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s00296-018-4065-6
更新日期:2018-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301265
更新日期:1993-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1479-1
更新日期:2011-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 历史文章,杂志文章
doi:10.1007/s00296-011-2007-7
更新日期:2012-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274777
更新日期:1990-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2090-9
更新日期:2012-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-011-1814-1
更新日期:2012-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04762-7
更新日期:2021-01-02 00:00:00
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can lead to damage to several vital organs. Antiphospholipid syndrome (APS), manifesting as vascular thromboembolic events and morbidities of pregnancy in the presence of antiphospholipid antibodies (aPL), has been described in patients with SLE...
journal_title:Rheumatology international
pub_type: 信件
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更新日期:2012-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0406-0
更新日期:2004-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301776
更新日期:1995-01-01 00:00:00
abstract::Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0006-2
更新日期:2006-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
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更新日期:2007-03-01 00:00:00
abstract::There are no standardized bedside assessments for subtyping patients with osteoarthritis (OA) based on pain mechanisms. Thus, we developed a bedside sensory testing kit (BSTK) to classify OA patients based on sensory profiles potentially indicative of pain mechanism. After usability and informal reliability testing (n...
journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
abstract::The results from previous studies on association of IL-6 -174 G/C and -572 G/C polymorphisms with the risk of systemic lupus erythematosus (SLE) remained inconsistent. Therefore, a meta-analysis was performed to assess the association between these two polymorphisms and SLE susceptibility. A literature-based search wa...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-02-01 00:00:00