Bisphosphonate-related osteonecrosis of the jaw in non-malignant bone disease.

Abstract:

:Bisphosphonates such as alendronate, risedronate and zoledronate have revolutionised the treatment for osteoporosis and Paget's disease. These drugs reduce fracture risk and probably mortality in patients with osteoporosis. However, they have a long in vivo half-life following cessation and may be associated with delayed dental healing and even the devastating complication of osteonecrosis of the jaw (ONJ). Extensive media attention highlighting this issue has caused much concern among patients and healthcare professionals. This paper seeks to provide treating clinicians with a balanced multi-disciplinary review of the available evidence pertaining to this issue and practical advice regarding prevention and management of ONJ.

journal_name

Rheumatol Int

authors

Wong PK,Borromeo GL,Wark JD

doi

10.1007/s00296-013-2771-7

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2189-98

issue

9

eissn

0172-8172

issn

1437-160X

journal_volume

33

pub_type

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