Experimental immune mediated arthritis in rhesus monkeys. A model for human rheumatoid arthritis?

Abstract:

:The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA.

journal_name

Rheumatol Int

authors

Bakker NP,van Erck MG,Zurcher C,Faaber P,Lemmens A,Hazenberg M,Bontrop RE,Jonker M

doi

10.1007/BF02274777

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

21-9

issue

1

eissn

0172-8172

issn

1437-160X

journal_volume

10

pub_type

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