Abstract:
:Resveratrol (trans-3,4'-trihydroxystilbene), a natural phytoalexin, possesses anti-inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for treating inflammatory disorders. The present study was designed to investigate the effects of resveratrol on TNF-α-induced inflammatory cytokines production of IL-1β and MMP3 in Rheumatoid arthritis (RA) Fibroblast-like synoviocytes (FLS) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production. The levels of IL-1β, MMP-3 in cultural supernatants among groups were measured by enzyme-linked immunosorbent assay. Messenger RNA expression of IL-1β and MMP-3 in RA FLS was analyzed using a reverse transcription-polymerase chain reaction. Western blot analysis was used to detect proteins expression in RA FLS intervened by resveratrol. Resveratrol inhibited both mRNA and proteins expressions of IL-1β and MMP-3 on RA FLS in a dose-dependent manner. Resveratrol also decreased significantly the expression of phosphorylated Akt dose dependently. Activation of PI3K/Akt signaling pathway exists in TNF-α-induced production of IL-1β and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002. Immunofluorescence staining showed that TNF-α alone increased the production of P-Akt, whereas LY294002 and 50 μM resveratrol suppressed the TNF-α-stimulated expression of P-Akt. Resveratrol attenuates TNF-α-induced production of IL-1β and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Tian J,Chen JW,Gao JS,Li L,Xie Xdoi
10.1007/s00296-012-2657-0subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1829-35issue
7eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract::We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estim...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2611-1
更新日期:2013-12-01 00:00:00
abstract::Serotonin antagonists show impressive analgesic efficacy in rheumatoid arthritis, osteoarthritis (OA) or fibromyalgia; however, this effect is not well understood. We examined the mechanism of serotonin-induced inflammation and its antagonists in OA. Serotonin receptor subtypes and COX-2 were analysed by RT-PCR from s...
journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1765-y
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1280-1
更新日期:2011-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301776
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3077-0
更新日期:2015-02-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2238-7
更新日期:2012-12-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4044-y
更新日期:2018-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050079
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0980-x
更新日期:2010-02-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0899-2
更新日期:2009-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2056-y
更新日期:2012-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3987-3
更新日期:2018-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3861-8
更新日期:2018-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0441-3
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2109-2
更新日期:2012-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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更新日期:2021-01-16 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00