Abstract：
:Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scarce and the results are diverse. This meta-analysis was performed to determine if CCL21 gene polymorphisms correlate with the risk of developing RA. Association reports for the relationship between CCL21 polymorphisms and RA were identified from PubMed, Cochrane Library, Embase, SCIELO, CNKI and Wanfang databases on March 22, 2017. The odds ratio (OR) and 95% confidence interval (CI) were applied to assess the relationship strength. Publication bias was conducted with Begg's funnel plot and Egger's regression test to measure the robustness of our findings. Sensitivity and cumulative analyses were used to assess the overall robustness of the study's results. Four relevant case-control cohort studies and three GWAS studies with CCL21rs2812378G>A gene polymorphisms and rheumatoid arthritis involving 9963 RA cases and 7976 controls were identified. Significant associations between the CCL21 rs2812378G>A polymorphism and RA risk were observed in the co-dominant model, dominant model and heterozygous model (A vs G: OR = 1.08, 95% CI = 1.03-1.14, p < 0.01, I 2 = 0.0%; AA + AG vs GG: OR = 1.15, 95% CI = 1.05-1.28, p < 0.01, I 2 = 0.0%; AG vs GG: OR = 1.18, 95% CI = 1.08-1.30, p < 0.01, I 2 = 3.8%) in the total population, as well as in subgroup Caucasian population. The combined analysis revealed a significantly increased risk of rheumatoid arthritis in the co-dominant model, dominant model and heterozygous model in overall population and subgroup Caucasian population.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Li G,Zhao J,Li B,Ma J,Zhao Q,Wang X,Lv Z,Li K,Du Z,Ma X,Liu Jdoi
10.1007/s00296-017-3784-4subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1673-1681issue
10eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-017-3784-4journal_volume
37pub_type
杂志文章,meta分析,评审abstract：:One hundred and eighteen unrelated Greek patients with classic rheumatoid arthritis (RA) were tissue-typed for HLA-A, -B, -DR antigens and the frequency was compared to that of healthy controls. Greek RA patients regardless of sex, anatomical severity, seropositivity and age at disease onset are not associated with an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541336
更新日期：1985-01-01 00:00:00
abstract：:Fibromyalgia (FM) is the most common chronic pain syndrome encountered in medical practice, affecting females more than males, and the estimated prevalence of FM in Egypt is 1.3 %. The aim was to translate and adapt the Fibromyalgia Impact Questionnaire (FIQ) into Arabic and assess reliability and validity. The Arabic...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2779-z
更新日期：2013-10-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the worldwide population. RA is associated with multiple extra-articular manifestations (EAMs). Middle ear, cochlea and the auditory nerve are suspected sites of RA activity and hearing loss is a possible novel EAM of RA. Objective was to...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04609-1
更新日期：2020-11-01 00:00:00
abstract：:Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital betwe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2808-y
更新日期：2013-11-01 00:00:00
abstract：:The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541245
更新日期：1982-01-01 00:00:00
abstract：:Neurocognitive dysfunction and brain injury on magnetic resonance imaging (MRI) are common in patients with systemic lupus erythematosus (SLE) and are associated with increased morbidity and mortality. However, brain MRI is expensive, is restricted by payers, and requires high expertise. Neurocognitive assessment is a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4080-7
更新日期：2018-08-01 00:00:00
abstract：:The aim of this study was to compare the efficacy of sodium hyaluronate (SH) injection with the most common treatment methods, intraarticular steroid injection and physical therapy modalities in patients with adhesive capsulitis (AC). A total of 95 shoulders of 90 patients were included in the study and were randomize...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-005-0022-2
更新日期：2006-04-01 00:00:00
abstract：:Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541597
更新日期：1983-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint pain, inflammation, and loss of function. Disease pathogenesis involves activation and proliferation of autoreactive pro-inflammatory effector T cells. While the details of RA onset and progression remain controversial, dendritic cell (DC) nu...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3671-z
更新日期：2017-07-01 00:00:00
abstract：:Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patie...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04335-3
更新日期：2019-09-01 00:00:00
abstract：:An immunoglobulin-independent deposition of the complement (C) components C4 and C3 occurs on rat kidney medullary structures, when sera of patients with various inflammatory diseases are studied by indirect immunofluorescence. The diagnostic value of this new test (C4-C3-IFT) for polymyalgia rheumatica (PMR) is stres...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00271838
更新日期：1988-01-01 00:00:00
abstract：:We characterized the anemia in monkey collagen-induced arthritis (CIA) to evaluate whether this model is useful to analyze the basis of an anemia of inflammatory diseases. Cynomolgus monkey was immunized with bovine type II collagen on days 0 and 21. Blood samples were collected regularly and hematological parameters,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0547-2
更新日期：2008-07-01 00:00:00
abstract：:Fibrosis is unregulated tissue repair that may cause impairment of organ function, especially in end-organ damage. Systemic sclerosis (SSc) is the prototype systemic fibrosing disorder. Classical targets for fibrosis in SSc like transforming growth factor Beta (TGF-β), Interleukin-6 (IL-6), and multiple tyrosine kinas...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04317-5
更新日期：2019-07-01 00:00:00
abstract：:3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00301776
更新日期：1995-01-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0638-0
更新日期：2008-11-01 00:00:00
abstract：:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4102-5
更新日期：2018-09-01 00:00:00
abstract：:Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely repo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1490-6
更新日期：2012-09-01 00:00:00
abstract：:Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1196-9
更新日期：2010-02-01 00:00:00
abstract：:The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was det...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3495-2
更新日期：2016-08-01 00:00:00
abstract：:When compared to general population, patients with rheumatoid arthritis are at higher risk of some malignancies (especially lymphomas and lung cancer). Genetic predisposition, chronic inflammatory stimuli and viral infections are some of the reasons untreated patients are at higher risk. Clinical studies and national/...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04706-1
更新日期：2021-02-01 00:00:00
abstract：:Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04689-z
更新日期：2021-02-01 00:00:00
abstract：:Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050033
更新日期：1998-01-01 00:00:00
abstract：:To define and give priority to standards of care and quality indicators of multidisciplinary care for patients with psoriatic arthritis (PsA). A systematic literature review on PsA standards of care and quality indicators was performed. An expert panel of rheumatologists and dermatologists who provide multidisciplinar...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3986-4
更新日期：2018-06-01 00:00:00
abstract：:Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04386-6
更新日期：2019-09-01 00:00:00
abstract：:The aim of the present study was to evaluate the effects of an exercise training program on lipid profile and composition of high-density lipoprotein (HDL) subfractions in systemic lupus erythematosus (SLE) patients and healthy controls. A 12-week, randomized trial was conducted. Thirty-three physically inactive SLE p...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-014-3081-4
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:There is an overall increased risk of adverse pregnancy outcomes and maternal morbidity in patients with most autoimmune rheumatic diseases (ARD); outcomes are generally improved when the pregnancy is planned and the disease is in control. OBJECTIVE:The objective of the present study was to describe the sex...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04679-1
更新日期：2021-02-01 00:00:00
abstract：KEY MESSAGES:No difference between both hands was observed for clinical and radiographical presentations in EHOA patients. A bilateral and symmetrical relationship was found between hand joints. HIGHLIGHTS:EHOA have symmetrical distribution and specific association in structural lesions. This study aims to analyse the...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04784-1
更新日期：2021-01-27 00:00:00
abstract：:Research suggests that health literacy (HL) is associated with rheumatoid arthritis (RA) patients' functional status. Single-item health literacy screening (SILS) questionnaires may establish patients' HL; however, the wording of SILS may be misinterpreted by RA patients as a query regarding physical limitations. Desp...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3238-9
更新日期：2015-09-01 00:00:00
abstract：:Catalase (CAT) and peroxisome proliferator activated receptor-gamma2 (PPARgamma2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARgamma2 genotypes and risk and severity of RA using 474...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0013-3
更新日期：2006-03-01 00:00:00
abstract：:Citrulline antibody, nowadays, is a new item which has been the center of attention due to its much more specificity to diagnose RA. The aim of the present study was to evaluate the efficacy and accuracy of anti-citrulline antibody test in RA diagnosis among hospitalized patients in Iran. Through a case-control study,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2469-2
更新日期：2013-04-01 00:00:00
