Abstract：
:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigue over time. Data from the tREACH study were used, comparing different treatment strategies with fatigue as secondary objective. Patient outcomes on fatigue, quality of life, depression, and coping were obtained every 6 months and clinically assessed every 3 months. Prediction of fatigue at 12 months was investigated with an ROC curve. Analysis was stratified into non-fatigue and fatigue at baseline. Logistic regression was used for the evolution of fatigue in relation with the covariates over time. Almost half of all patients (n = 246) had high fatigue levels at baseline, decreasing slightly over time. At 12 months, 43% of patients were fatigued; while 23% of the initially fatigued patients showed lower levels of fatigue, the fatigue level had increased in 15% of the initially non-fatigued patients. The strongest predictor of fatigue was the previous fatigue levels (AUC 0.89). Higher score on the depression scale and coping with limitations was associated with developing fatigue over time in the initially non-fatigued group. Despite a strict treat-to-target strategy, fatigue remained an overall problem during the first year of treatment, and was mainly predicted by its baseline status. In subgroups, a small additional effect of depression was seen. Monitoring fatigue and depression may be important in managing fatigue.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Walter MJM,Kuijper TM,Hazes JMW,Weel AE,Luime JJdoi
10.1007/s00296-018-4102-5subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1643-1650issue
9eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-018-4102-5journal_volume
38pub_type
杂志文章abstract：:Leg ulcers are a manifestation of antiphospholipid syndrome (APS), and characteristically respond poorly to treatment. Because the similar findings both clinical and pathological to pyoderma gangrenosum (PG), we treated these patients with a combination of immunosuppression (steroids, azathioprine or cyclosporine), ac...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1418-1
更新日期：2010-07-01 00:00:00
abstract：:We assess the usefulness of 99mTc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3584-2
更新日期：2016-12-01 00:00:00
abstract：:A community-based cohort comprising 150 patients with recent-onset seropositive arthritis or seronegative oligoarthritis or polyarthritis was monitored for 8 years. Of the different rheumatoid factor (RF) tests, the initial positivity in the most sensitive assays (latex slide test and IgM-RF by enzyme immunoassay) was...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541346
更新日期：1988-01-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is an autoimmune spondyloarthropathy involving principally the sacroiliac joint and axial skeleton. Spinal cord involvement is an infrequent and late complication. It mostly results from compressive myelopathy due to skeletal osteopathy and usually presents with radiculomyelopathic sensory ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1614-z
更新日期：2011-07-01 00:00:00
abstract：:We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0522-5
更新日期：2005-10-01 00:00:00
abstract：:The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with susceptibility to fibromyalgia and fibromyalgia impact questionnaire (FIQ) score in fibromyalgia patients. We conducted a meta-analysis of the associations of the COMT Val158Met polymorphism w...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-014-3075-2
更新日期：2015-01-01 00:00:00
abstract：:To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2463-8
更新日期：2013-04-01 00:00:00
abstract：:Behçet's disease (BD) is a variable vessel vasculitis characterized by recurrent oral and genital aphthosis accompanied by skin, ocular, gastrointestinal, neurologic, and articular involvement. BD is not common in childhood and the disease characteristics considerably differ between adults and children. 18 diagnostic/...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4208-9
更新日期：2019-01-01 00:00:00
abstract：:Schistosomiasis or bilharzia is a parasitic disease found in tropical countries. Most infections are subclinical but may progress to chronic form characterized most frequently by the presence of liver involvement and portal hypertension. We report a patient that presented chronic polyarthritis with positive rheumatoid...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1562-7
更新日期：2013-05-01 00:00:00
abstract：:Wells' syndrome is a multifaceted dermatosis with a wide morphological spectrum, ranging from characteristic cellulitis-like erythema and papula to an unusual presentation of vesicles and pustules. The most important elements for diagnosis are erythemal plaques and histological picture of eosinophilic infiltration of ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1809-y
更新日期：2012-04-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and J...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3358-2
更新日期：2016-02-01 00:00:00
abstract：:The Peptidyl arginine deiminase, type IV (PADI4) gene has been suggested to have an association with rheumatoid arthritis (RA) in several populations. But its role in Chinese RA is not clarified. We investigated five single-nucleotide polymorphisms (SNPs) of PADI4 as PADI4-89 (rs11203366), PADI4-90 (rs11203367), PADI4...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1519-x
更新日期：2011-12-01 00:00:00
abstract：:Fibrosis is unregulated tissue repair that may cause impairment of organ function, especially in end-organ damage. Systemic sclerosis (SSc) is the prototype systemic fibrosing disorder. Classical targets for fibrosis in SSc like transforming growth factor Beta (TGF-β), Interleukin-6 (IL-6), and multiple tyrosine kinas...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04317-5
更新日期：2019-07-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a severe complex rheumatic disease, but good estimate of its prevalence and risk factors is lacking in China. The aim of the study was to explore the prevalence of SLE and risk factors in rural areas of Anhui Province of China. Eleven counties were randomly selected in Anhui Provi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2902-1
更新日期：2014-03-01 00:00:00
abstract：:Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2194-2
更新日期：2012-11-01 00:00:00
abstract：:Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1074-5
更新日期：2010-08-01 00:00:00
abstract：:Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. The presence of nailfold capillary abnormalities is useful in diagnosing SSc. Capillaroscopy, however, usually requires special equipment and may be time consuming. Dermatoscope has been presented as...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1532-0
更新日期：2011-12-01 00:00:00
abstract：:This retrospective study analyzed the HLA-B 27 alleles in a group of 20 consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a tertiary referral university hospital in Brazil, during the period 1990-2006, and compared the data with that observed in other patients with spondyloarthropathies follo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0441-3
更新日期：2008-03-01 00:00:00
abstract：:Our aim was to investigate the relationship between the DNA methylation status of glucocorticoid receptor (GR) gene promoter and mRNA expression level of GRα gene of peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE). Fifteen newly emerging SLE patients and fifteen healthy c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3266-5
更新日期：2015-08-01 00:00:00
abstract：:This study was performed to evaluate the effects of the TNF-alpha inhibitor etanercept on oxidation stress markers representing DNA damage, lipid peroxidation, and protein glycosylation. Twenty-two rheumatoid arthritis (RA) patients underwent etanercept treatment. The levels of serum total, urinary total, and urinary ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0419-1
更新日期：2008-01-01 00:00:00
abstract：:To compare oxidative stress (OS) biomarkers and antioxidant capacity of plasma (ACP) between dcSSc (diffuse cutaneous systemic sclerosis) and healthy Mexicans and their possible relationship with autoantibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid (UA). We included 28 dcSSc an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2701-8
更新日期：2013-09-01 00:00:00
abstract：:Hydroxyapatite crystals are often deposited in the vicinity of joints, where they can cause a clinical periarthritis. Clodronate is a first-generation bisphosphonate that has the ability to reduce ectopic calcifications. Two women were affected by disabling calcific periarthritis of the shoulders lasting for years and...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1575-2
更新日期：2011-03-01 00:00:00
abstract：:The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002960050113
更新日期：2000-01-01 00:00:00
abstract：:To examine messages perceived by members of an osteoporosis (OP) patient group from various healthcare providers regarding bone health. We conducted a phenomenological (qualitative) study in members of an OP patient group who resided in Canada, had sustained a fragility fracture at 50+ years old, and were not taking a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3079-y
更新日期：2015-01-01 00:00:00
abstract：:We aimed to investigate how orbital blood flow rates in patients with rheumatoid arthritis (RA) are affected by the active and remission phase of the disease. This prospective study included a total of 56 patients with RA (study group) and 24 control individuals (control group). All RA patients were divided into two g...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04275-y
更新日期：2019-06-01 00:00:00
abstract：:A 47-year-old woman who had been treated for systemic lupus erythematosus (SLE) with myasthenia gravis (MG) was admitted to our hospital with acute onset of severe anemia after administration of isoniazid. Pure red cell aplasia (PRCA) was confirmed by elevated serum iron levels, reticulocytopenia and bone marrow aspir...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1113-2
更新日期：2010-11-01 00:00:00
abstract：:The cost-effectiveness of treatments that have the potential to change the "natural history" of a chronic progressive disease has to be evaluated over the long term. Cost-effectiveness estimates have been based on the concept that, with treatment, patients will not progress to the next level(s) of disease severity or ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1502-6
更新日期：2011-11-01 00:00:00
abstract：:Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2199-x
更新日期：2012-11-01 00:00:00
abstract：:Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in wome...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04591-8
更新日期：2020-09-01 00:00:00
abstract：:To develop a semi-automated method to quantify inflammation in sacroiliac (SI) joints by measuring bone marrow edema (BME) on MRI. The SCAISS was designed as an image-processing software. Validation followed: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4104-3
更新日期：2018-10-01 00:00:00
