Abstract:
:We characterized the anemia in monkey collagen-induced arthritis (CIA) to evaluate whether this model is useful to analyze the basis of an anemia of inflammatory diseases. Cynomolgus monkey was immunized with bovine type II collagen on days 0 and 21. Blood samples were collected regularly and hematological parameters, biochemical parameters and cytokine levels were monitored. Red blood cell (RBC) counts, hematocrit (Ht), and hemoglobin (Hb) gradually decreased after immunization and reached the bottom on day 35. CRP rose rapidly after first immunization and reached a peak on day 21. Serum iron levels and transferrin (Tf) saturation were dropped after immunization and reached a bottom on day 28. Thereafter it returned to normal. On the other hand, ferritin levels increased after immunization. IL-6 levels showed positive correlation with CRP, and negative correlation with Hb, RBC counts and serum iron, but TNFalpha did not show any correlation. In conclusion, the anemia in monkey CIA is very similar to human anemia of inflammatory diseases concerning the changes of serum parameters. And our data strongly suggest that IL-6 is an essential cytokine for the development of the anemia in monkey CIA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Uchiyama Y,Koike N,Mihara Mdoi
10.1007/s00296-008-0547-2subject
Has Abstractpub_date
2008-07-01 00:00:00pages
879-83issue
9eissn
0172-8172issn
1437-160Xjournal_volume
28pub_type
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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